↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Dernstedt A) "

Search: WFRF:(Dernstedt A)

Result 1-2 of 2

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Dernstedt, A, et al. (author) Regulation of decay accelerating factor primes human germinal center B Cells for phagocytosis 2021 In: EUROPEAN JOURNAL OF IMMUNOLOGY. - 0014-2980. ; 51, s. 155-155 Conference paper (other academic/artistic)
2.	Kerkman, Priscilla, et al. (author) Generation of plasma cells and CD27-IgD- B cells during hantavirus infection is associated with distinct pathological findings 2021 In: Clinical & Translational Immunology (CTI). - : John Wiley & Sons. - 2050-0068. ; 10 Journal article (peer-reviewed)abstract Objective: Human hantavirus infections can cause haemorrhagic fever with renal syndrome (HFRS). The pathogenic mechanisms arenot fully understood, nor if they affect the humoral immune system. The objective of this study was to investigate humoral immune responses to hantavirus infection and to correlate them to the typical features of HFRS: thrombocytopenia and transient kidney dysfunction.Methods: We performed a comprehensive characterisation of longitudinal antiviral B-cell responses of 26 hantavirus patients and combined this with paired clinical data. In addition, we measured extracellular adenosine triphosphate (ATP)and its breakdown products in circulation and performed in vitro stimulations to address its effect on B cells.Results: We found that thrombocytopenia was correlated to an elevated frequency of plasmablasts in circulation. In contrast, kidney dysfunction was indicative of an accumulation of CD27-IgD- B cells and CD27/low plasmablasts. Finally, we provide evidence that high levels of extracellular ATP and matrix metalloproteinase 8 can contribute to shedding of CD27 during human hantavirus infection.Conclusion: Our findings demonstrate that thrombocytopenia and kidneydysfunction associate with distinctly different effects on the humoral immune system. Moreover, hantavirus-infectedindividuals have significantly elevated levels of extracellular ATP incirculation.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-2 of 2

Refine your search

Type of publication: conference paper (1); journal article (1)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Ahlm, Clas, 1956- (1); Ahlm, C. (1); Forsell, Mattias N. ... (1); Mjosberg, J (1); Henriksson, J (1); Klingström, Jonas (1); show more...; Holm, A. (1); Puhar, Andrea, 1978- (1); Hultdin, M (1); Jangra, Rohit K. (1); Chandran, Kartik (1); Tauriainen, Johanna (1); Forsell, MN (1); Dernstedt, Andy (1); Kerkman, Priscilla (1); Dernstedt, A (1); Leidig, J (1); Kerkman, PF (1); Ocaya, Pauline (1); Thunberg, Therese, 1 ... (1); Sundling, Christophe ... (1); Tadala, Lalitha (1); Mittler, Eva (1); Dannborg, Mirjam (1); Maleki, Kimia T. (1); Tuiskunen-Bäck, Anne (1); Wigren Byström, Juli ... (1); Román-Sosa, Gleyder (1); Guardado-Calvo, Pabl ... (1); Rey, Feilx A. (1); show less...

University: Karolinska Institutet (2); Umeå University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2021 (2)

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view