| 1. |
- Agten, Pieter, et al.
(författare)
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JSand: Complete client-side sandboxing of third-party JavaScript without browser modifications
- 2012
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Ingår i: Proceedings of ACSAC'2012 Annual Computer Security Applications Conference, Orlando, 3-7 December 2012. - New York, NY, USA : ACM. - 9781450313124 ; 1, s. 1-10
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Konferensbidrag (refereegranskat)abstract
- The inclusion of third-party scripts in web pages is a common practice. A recent study has shown that more than half of the Alexa top 10 000 sites include scripts from more than 5 different origins. However, such script inclusions carryrisks, as the included scripts operate with the privileges of the including website.We propose JSand, a server-driven but client-side JavaScript sandboxing framework. JSand requires no browsermodifications: the sandboxing framework is implemented inJavaScript and is delivered to the browser by the websitesthat use it. Enforcement is done entirely at the client side:JSand enforces a server-specified policy on included scriptswithout requiring server-side filtering or rewriting of scripts.Most importantly, JSand is complete: access to all resourcesis mediated by the sandbox.We describe the design and implementation of JSand, andwe show that it is secure, backwards compatible, and thatit performs sufficiently well.
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| 2. |
- De Winter, Sabrina, et al.
(författare)
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Quantification and Explanation of the Variability of First-Dose Amikacin Concentrations in Critically Ill Patients Admitted to the Emergency Department : A Population Pharmacokinetic Analysis
- 2021
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Ingår i: European journal of drug metabolism and pharmacokinetics. - : Springer Nature. - 0378-7966 .- 2107-0180. ; 46, s. 653-663
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Tidskriftsartikel (refereegranskat)abstract
- Background: There may be a difference between the determinants of amikacin exposure in emergency department (ED) versus intensive care (ICU) patients, and the peak amikacin concentration varies widely between patients. Moreover, when the first dose of antimicrobials is administered to septic patients admitted to the ED, fluid resuscitation and vasopressors have just been initiated. Nevertheless, population pharmacokinetic modelling data for amikacin in ED patients are unavailable.Objective: The aim of this study was to quantify the interindividual variability (IIV) in the pharmacokinetics of amikacin in patients admitted to the ED and to identify the patient characteristics that explain this IIV.Methods: Patients presenting at the ED with severe sepsis or septic shock were randomly assigned to receive amikacin 25 mg/kg or 15 mg/kg intravenously. Blood samples were collected at 1, 6 and 24 h after the onset of the first amikacin infusion. Data were analysed using nonlinear mixed-effects modelling.Results: A two-compartment population pharmacokinetic model was developed based on 279 amikacin concentrations from 97 patients. The IIV in clearance (CL) and central distribution volume (V-1) were 71% and 26%, respectively. Body mass index (BMI), serum total protein level, serum sodium level, and fluid balance 24 h after amikacin administration explained 30% of the IIV in V-1, leaving 18% of the IIV unexplained. BMI and creatinine clearance according to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation 24 h after amikacin administration explained 46% of the IIV in CL, and 39% remained unexplained.Conclusion: The IIV of amikacin pharmacokinetics in ED patients is large. Higher doses may be considered in patients with low serum sodium levels, low total protein levels, or a high fluid balance.
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| 4. |
- Enquist, Henrik, et al.
(författare)
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Intuition in Design and Emotion – Transforming raw data into conclusions, a meta-analysis of the 2006 Design and Emotion conference papers.
- 2008
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Ingår i: [Host publication title missing]. - 9789881748928
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Konferensbidrag (refereegranskat)abstract
- In any research field the transformation of raw data into conclusions is a critical phase, necessitating a systematic approach. The basic question is: How can I as a (design) researcher corroborate my conclusions? This paper is based on a study of the analytical/interpretative portion of papers published in the Proceedings of the 2006 Design & Emotion Conference. We investigate how the authors present the interpretative process in their papers, such as using specific methods for interpretation and analysis. It became obvious that there were few specific methods for interpretation mentioned in the Conference papers studied, though there was a wide range of methodological approaches from theoretical and statistical to purely qualitative. Notably, most papers did not mention any method at all. The issue of interpretation is certainly not new, but in the light of the topic of design for emotions, design (research) by emotions or intuition should be discussed.
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