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Träfflista för sökning "WFRF:(Devaney Nicholas) "

Search: WFRF:(Devaney Nicholas)

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1.
  • Gontcharov, Alexander, et al. (author)
  • Adaptive optics for the Euro50: design and performance
  • 2003
  • In: Future Giant Telescopes. Proceedings of the SPIE. - : SPIE. - 081944619X ; 4840, s. 36-46
  • Conference paper (peer-reviewed)abstract
    • The optical design for the proposed Euro50 extremely large telescopewith integrated adaptive optics (AO) is presented. For atmosphericturbulence correction, we propose using single and dual-conjugate AOsystems working with natural and laser guide stars. The corrective shapeof the deformable mirrors (DMs) is derived from an analytical algorithmbased on minimization of the sum of the residual power spectra of thephase fluctuations seen by guide stars after correction. Predictions forperformance of the Euro50 ELT with Dual-conjugate AO are given for the Kband using a seven layer atmospheric model for the atmosphere at theObservatorio del Roque de los Muchachos (ORM) on La Palma. The averageStrehl ratio is used to quantify the system performance for differentvalues of actuator pitch and DM conjugation altitudes. The influence ofthe outer scale and telescope pointing on the RMS stroke of the DMs ispresented. It is concluded that construction of such a system isfeasible and that there is a need for development of a simulation toolto verify the analytical calculations. Precise knowledge of the outerscale of the atmosphere at the ORM is needed to establish the dynamicalrange of the mirrors.
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2.
  • Soranzo, Nicole, et al. (author)
  • A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
  • 2009
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:11, s. 38-1182
  • Journal article (peer-reviewed)abstract
    • The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
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