| 1. |
|
|
| 2. |
- Wu, Jie, et al.
(author)
-
The impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort : the Shanghai Aging Study
- 2024
-
In: Alzheimer's Research & Therapy. - : BioMed Central (BMC). - 1758-9193. ; 16:1
-
Journal article (peer-reviewed)abstract
- BACKGROUND: The blood-based biomarkers are approaching the clinical practice of Alzheimer's disease (AD). Chronic kidney disease (CKD) has a potential confounding effect on peripheral protein levels. It is essential to characterize the impact of renal function on AD markers.METHODS: Plasma phospho-tau181 (P-tau181), and neurofilament light (NfL) were assayed via the Simoa HD-X platform in 1189 dementia-free participants from the Shanghai Aging Study (SAS). The estimated glomerular filter rate (eGFR) was calculated. The association between renal function and blood NfL, P-tau181 was analyzed. An analysis of interactions between various demographic and comorbid factors and eGFR was conducted.RESULTS: The eGFR levels were negatively associated with plasma concentrations of NfL and P-tau181 (B = - 0.19, 95% CI - 0.224 to - 0.156, P < 0.001; B = - 0.009, 95% CI - 0.013 to -0.005, P < 0.001, respectively). After adjusting for demographic characteristics and comorbid diseases, eGFR remained significantly correlated with plasma NfL (B = - 0.010, 95% CI - 0.133 to - 0.068, P < 0.001), but not with P-tau181 (B = - 0.003, 95% CI - 0.007 to 0.001, P = 0.194). A significant interaction between age and eGFR was found for plasma NfL (Pinteraction < 0.001). In participants ≥ 70 years and with eGFR < 60 ml/min/1.73 m2, the correlation between eGFR and plasma NfL was significantly remarkable (B = - 0.790, 95% CI - 1.026 to - 0,554, P < 0.001).CONCLUSIONS: Considering renal function and age is crucial when interpreting AD biomarkers in the general aging population.
|
|
| 3. |
- Huang, Shoushuang, et al.
(author)
-
Encapsulating Fe2O3 Nanotubes into Carbon-Coated Co9S8 Nanocages Derived from a MOFs-Directed Strategy for Efficient Oxygen Evolution Reactions and Li-Ions Storage
- 2021
-
In: Small. - : Wiley-V C H Verlag GMBH. - 1613-6810 .- 1613-6829. ; 17:51
-
Journal article (peer-reviewed)abstract
- The development of high-efficiency, robust, and available electrode materials for oxygen evolution reaction (OER) and lithium-ion batteries (LIBs) is critical for clean and sustainable energy system but remains challenging. Herein, a unique yolk-shell structure of Fe2O3 nanotube@hollow Co9S8 nanocage@C is rationally prepared. In a prearranged sequence, the fabrication of Fe2O3 nanotubes is followed by coating of zeolitic imidazolate framework (ZIF-67) layer, chemical etching of ZIF-67 by thioacetamide, and eventual annealing treatment. Benefiting from the hollow structures of Fe2O3 nanotubes and Co9S8 nanocages, the conductivity of carbon coating and the synergy effects between different components, the titled sample possesses abundant accessible active sites, favorable electron transfer rate, and exceptional reaction kinetics in the electrocatalysis. As a result, excellent electrocatalytic activity for alkaline OER is achieved, which delivers a low overpotential of 205 mV at the current density of 10 mA cm(-2) along with the Tafel slope of 55 mV dec(-1). Moreover, this material exhibits excellent high-rate capability and excellent cycle life when employed as anode material of LIBs. This work provides a novel approach for the design and the construction of multifunctional electrode materials for energy conversion and storage.
|
|
| 4. |
- Xiao, Zhenxu, et al.
(author)
-
Olfactory function, neurofilament light chain, and cognitive trajectory : A 12-year follow-up of the Shanghai Aging Study
- 2023
-
In: Alzheimer's and Dementia. - : John Wiley & Sons. - 2352-8729. ; 15:4
-
Journal article (peer-reviewed)abstract
- This study aimed to determine whether blood neurofilament light chain (NfL) modifies the association of olfactory dysfunction (OD) with long-term cognitive decline. A total of 1125 non-demented older adults in the Shanghai Aging Study were evaluated for baseline olfaction (12-item Sniffin' Sticks Smell Test) and cognitive trajectory by a 12-year follow-up. Baseline blood NfL was quantified using Single Molecular Array assay, and dichotomized into low and high levels based on the median value of concentration. The Mini-Mental State Examination (MMSE) and Telephone Interview for Cognitive Status-40 were used to assess participants' cognitive function. Cognitive decline was ascertained when dementia was diagnosed or documented in the medical record during follow-up, or the MMSE declining rate (slope) was 1.0 SD larger than the group mean. OD participants presented a steeper trajectory of MMSE score (p interaction = 0.004) and a high risk of cognitive decline (adjusted HR [95% CI], 1.82 [1.11, 2.98]) only in those with high NfL. Participants with combined OD and high NfL showed the highest risk of cognitive decline (adjusted HR, 2.43 [1.20, 4.92]). OD, especially in combination with high blood NfL concentration, may be able to identify individuals who later incur cognitive deterioration.
|
|
| 5. |
- Xiao, Zhenxu, et al.
(author)
-
Plasma p-tau217, p-tau181, and NfL as early indicators of dementia risk in a community cohort : The Shanghai Aging Study
- 2023
-
In: Alzheimer's and Dementia. - : John Wiley & Sons. - 2352-8729. ; 15:4
-
Journal article (peer-reviewed)abstract
- INTRODUCTION: Blood biomarkers showed values for predicting future cognitive impairment. Evidence from the community-based cohort was limited only in high-income countries.METHODS: This study included 1857 dementia-free community residents recruited in 2009-2011 and followed up in waves 2014-2016 and 2019-2023 in the Shanghai Aging Study. We intended to explore the relationships of baseline plasma ALZpath phosphorylated tau 217 (p-tau217), p-tau181, neurofilament light chain (NfL) with follow-up incident dementia, Alzheimer's disease (AD), and amyloidosis.RESULTS: Higher concentrations of plasma p-tau217, p-tau181, and NfL were correlated to higher decline speed of Mini-Mental State Examination score, and higher risk of incident dementia and AD. The p-tau217 demonstrated a significant correlation with longitudinal neocortical amyloid-beta (Aβ) deposition (r = 0.57 [0.30, 0.76]) and a high accuracy differentiating Aβ+ from Aβ- at follow-ups (area under the receiver operating characteristic curve = 0.821 [0.703, 0.940]).DISCUSSION: Plasma p-tau217 may be an early predictive marker of AD and Aβ pathology in older community-dwelling individuals.Highlights: Plasma p-tau217, p-tau181, and NfL were positively associated with long-term cognitive decline and risk of incident dementia.Plasma p-tau217 showed a better performance distinguishing Aβ+ individuals from Aβ- individuals at follow-ups.Plasma NfL may be a suitable predictor of general cognitive decline in older community-dwelling individuals.
|
|
| 6. |
- Niemi, MEK, et al.
(author)
-
- 2021
-
swepub:Mat__t
|
|
| 7. |
-
- 2019
-
Journal article (peer-reviewed)
|
|
| 8. |
- Ablikim, M., et al.
(author)
-
Search for h(c) -> pi(+)pi(-) J/psi via psi(3686) -> pi(0)pi(+)pi(-) J/psi
- 2018
-
In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 97:5
-
Journal article (peer-reviewed)abstract
- Using a data sample of 448.1 x 10(6) psi(3686) events collected with the BESIII detector operating at the BEPCII, we perform search for the hadronic transition h(c)-> pi(+)pi(-) J/psi via psi (3686) -> pi(0)hc. No signals of the transition are observed, and the upper limit on the product branching fraction B(sigma(3686) -> pi(0)h(c))B(h(c) -> pi(+)pi(-) J/psi) at the 90% confidence level (C. L.) is determined to be 2.0 x 10(-6). This is the most stringent upper limit to date.
|
|
| 9. |
- Aronov, Boris, et al.
(author)
-
Are Friends of My Friends Too Social? Limitations of Location Privacy in a Socially-Connected World
- 2018
-
In: PROCEEDINGS OF THE 2018 THE NINETEENTH INTERNATIONAL SYMPOSIUM ON MOBILE AD HOC NETWORKING AND COMPUTING (MOBIHOC 18). - New York, NY, USA : ASSOC COMPUTING MACHINERY. - 9781450357708 ; , s. 280-289
-
Conference paper (peer-reviewed)abstract
- With the ubiquitous adoption of smartphones and mobile devices, it is now common practice for ones location to be sensed, collected and likely shared through social platforms. While such data can be helpful for many applications, users start to be aware of the privacy issue in handling location and trajectory data. While some users may voluntarily share their location information (e.g., for receiving location-based services, or for crowdsourcing systems), their location information may lead to information leaks about the whereabouts of other users, through the co-location of events when two users are at the same location at the same time and other side information, such as upper bounds of movement speed. It is therefore crucial to understand how much information one can derive about others positions through the co-location of events and occasional GPS location leaks of some of the users. In this paper we formulate the problem of inferring locations of mobile agents, present theoretically-proven bounds on the amount of information that could be leaked in this manner, study their geometric nature, and present algorithms matching these bounds. We will show that even if a very weak set of assumptions is made on trajectories patterns, and users are not obliged to follow any reasonable patterns, one could infer very accurate estimation of users locations even if they opt not to share them. Furthermore, this information could be obtained using almost linear-time algorithms, suggesting the practicality of the method even for huge volumes of data.
|
|
| 10. |
- Belfield, Eric J., et al.
(author)
-
Thermal stress accelerates Arabidopsis thaliana mutation rate
- 2021
-
In: Genome Research. - : COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT. - 1088-9051 .- 1549-5469. ; 31:1, s. 40-50
-
Journal article (peer-reviewed)abstract
- Mutations are the source of both genetic diversity and mutational load. However, the effects of increasing environmental temperature on plant mutation rates and relative impact on specific mutational classes (e.g., insertion /deletion [indel] vs. single nucleotide variant [SNV]) are unknown. This topic is important because of the poorly defined effects of anthropogen ic global temperature rise on biological systems. Here, we show the impact of temperature increase on Arabidopsis thaliana mutation, studying whole genome profiles of mutation accumulation (MA) lineages grown for 11 successive generations at 29 degrees C. Whereas growth of A. thaliana at standard temperature (ST; 23 degrees C) is associated with a mutation rate of 7 x10(-9) base substitutions per site per generation, growth at stressful high temperature (HT; 29 degrees C) is highly mutagenic, increasing the mutation rate to 12 x 10(-9). SNV frequency is approximately two- to threefold higher at HT than at ST, and HT-growth causes an similar to 19- to 23-fold increase in indel frequency, resulting in a disproportionate increase in indels (vs. SNVs). Most HT-induced indels are 1-2 bp in size and particularly affect homopolymeric or dinucleotide A or T stretch regions of the genome. HT-induced indels occur disproportionately in nucleosome-free regions, suggesting that much HT-induced mutational damage occurs during cell-cycle phases when genomic DNA is packaged into nucleosomes. We conclude that stressful experimental temperature increases accelerate plant mutation rates and particularly accelerate the rate of indel mutation. Increasing environmental temperatures are thus likely to have significant mutagenic consequences for plants growing in the wild and may, in particular, add detrimentally to mutational load.
|
|
