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1.	Allen, GI, et al. (author) Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease 2016 In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 12:6, s. 645-653 Journal article (peer-reviewed)
2.	Kiddle, SJ, et al. (author) Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study 2014 In: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 38:3, s. 515-531 Journal article (peer-reviewed)
3.	Kiddle, SJ, et al. (author) Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes 2015 In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 5, s. e584- Journal article (peer-reviewed)abstract There is great interest in blood-based markers of Alzheimer’s disease (AD), especially in its pre-symptomatic stages. Therefore, we aimed to identify plasma proteins whose levels associate with potential markers of pre-symptomatic AD. We also aimed to characterise confounding by genetics and the effect of genetics on blood proteins in general. Panel-based proteomics was performed using SOMAscan on plasma samples from TwinsUK subjects who are asymptomatic for AD, measuring the level of 1129 proteins. Protein levels were compared with 10-year change in CANTAB-paired associates learning (PAL; n=195), and regional brain volumes (n=34). Replication of proteins associated with regional brain volumes was performed in 254 individuals from the AddNeuroMed cohort. Across all the proteins measured, genetic factors were found to explain ~26% of the variability in blood protein levels on average. The plasma level of the mitogen-activated protein kinase (MAPK) MAPKAPK5 protein was found to positively associate with the 10-year change in CANTAB-PAL in both the individual and twin difference context. The plasma level of protein MAP2K4 was found to suggestively associate negatively (Q<0.1) with the volume of the left entorhinal cortex. Future studies will be needed to assess the specificity of MAPKAPK5 and MAP2K4 to eventual conversion to AD.
4.	Roubroeks, JAY, et al. (author) An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene 2020 In: Neurobiology of aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 95, s. 26-45 Journal article (peer-reviewed)
5.	Sattlecker, M, et al. (author) Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology 2014 In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 10:6, s. 724-734 Journal article (peer-reviewed)

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Type of publication: journal article (5)

Type of content: peer-reviewed (5)

Author/Editor: Lovestone, S (5); Simmons, A. (4); Soininen, H (4); Kloszewska, I (4); Mecocci, P (4); Vellas, B (4); show more...; Tsolaki, M (4); Westman, E (3); Williams, S. (2); Nelson, S. (2); Xie, Y. (1); Aarsland, D (1); Lee, E. (1); Das, S. (1); Bennett, DA (1); Bellotti, R. (1); Wahlund, LO (1); Breen, G (1); Hwang, J (1); Xu, J (1); Klein, A (1); Ghosh, SS (1); Curtis, C (1); Green, RC (1); Weiner, MW (1); Xie, L. (1); Krause, R. (1); Mill, J (1); Peters, MA (1); Mangravite, LM (1); Boutros, PC (1); Shen, X (1); Caberlotto, L (1); Allen, GI (1); Amoroso, N (1); Anghel, C (1); Balagurusamy, V (1); Bare, CJ (1); Beaton, D (1); Boehme, KL (1); Caloian, C (1); Campbell, F (1); Neto, EC (1); Chang, YC (1); Chen, BB (1); Chen, CY (1); Chien, TY (1); Clark, T (1); Davatzikos, C (1); Deng, JY (1); show less...

University: Karolinska Institutet (5)

Language: English (5)

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