| 1. |
|
|
| 2. |
|
|
| 3. |
- Babulal, Ganesh M, et al.
(författare)
-
Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need.
- 2019
-
Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 15:2, s. 292-312
-
Tidskriftsartikel (refereegranskat)abstract
- Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross-PIA white paper that provides both a concise "state-of-the-science" report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Castellani, Carlo, et al.
(författare)
-
Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice
- 2008
-
Ingår i: Journal of Cystic Fibrosis. - : Elsevier BV. - 1569-1993 .- 1873-5010. ; 7:3, s. 179-96
-
Tidskriftsartikel (refereegranskat)abstract
- It is often challenging for the clinician interested in cystic fibrosis (CF) to interpret molecular genetic results, and to integrate them in the diagnostic process. The limitations of genotyping technology, the choice of mutations to be tested, and the clinical context in which the test is administered can all influence how genetic information is interpreted. This paper describes the conclusions of a consensus conference to address the use and interpretation of CF mutation analysis in clinical settings. Although the diagnosis of CF is usually straightforward, care needs to be exercised in the use and interpretation of genetic tests: genotype information is not the final arbiter of a clinical diagnosis of CF or CF transmembrane conductance regulator (CFTR) protein related disorders. The diagnosis of these conditions is primarily based on the clinical presentation, and is supported by evaluation of CFTR function (sweat testing, nasal potential difference) and genetic analysis. None of these features are sufficient on their own to make a diagnosis of CF or CFTR-related disorders. Broad genotype/phenotype associations are useful in epidemiological studies, but CFTR genotype does not accurately predict individual outcome. The use of CFTR genotype for prediction of prognosis in people with CF at the time of their diagnosis is not recommended. The importance of communication between clinicians and medical genetic laboratories is emphasized. The results of testing and their implications should be reported in a manner understandable to the clinicians caring for CF patients.
|
|
| 10. |
- Duell, Natasha, et al.
(författare)
-
A cross-sectional examination of response inhibition and working memory on the Stroop task
- 2018
-
Ingår i: Cognitive development. - : Elsevier BV. - 0885-2014 .- 1879-226X. ; 47, s. 19-31
-
Tidskriftsartikel (refereegranskat)abstract
- The authors examined the association between working memory and response inhibition on the Stroop task using a cross-sectional, international sample of 5099 individuals (49.3% male) ages 10–30 (M = 17.04 years; SD = 5.9). Response inhibition was measured using a Stroop task that included "equal" and "unequal" blocks, during which the relative frequency of neutral and incongruent trials was manipulated. Competing stimuli in incongruent trials evinced inhibitory functioning, and having a lower proportion of incongruent trials (as in unequal blocks) placed higher demands on working memory. Results for accuracy indicated that age and working memory were independently associated with response inhibition. Age differences in response inhibition followed a curvilinear trajectory, with performance improving into early adulthood. Response inhibition was greatest among individuals with high working memory. For response time, age uniquely predicted response inhibition in unequal blocks. In equal blocks, age differences in response inhibition varied as a function of working memory, with age differences being least pronounced among individuals with high working memory. The implications of considering the association between response inhibition and working memory in the context of development are discussed.
|
|
