| 1. |
- Chen, Guanghui, et al.
(author)
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Optimization of tunnel support parameters with consideration of seismic wave radiation pattern in the fault-slip burst
- 2017
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In: Journal of Mining and Safety Engineering. - : China University of Mining and Technology. - 1673-3363. ; 34:4, s. 715-722
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Journal article (peer-reviewed)abstract
- As the underground mining extends gradually towards depth, more and more seismic events induced by fault slip occur and cause great damages, which have become a severe potential threat to mining safety. In view of the plane strain problems, through the three dimensional discrete model established, comparison and analysis was carried out between the equivalent calculation of plane strain in 3D model and a 2D discrete model. The results have shown that the research model developed to simulate the propagation of seismic wave in 3D is feasible and applicable. The study of the effect of radiation pattern on seismic propagation revealed and tested the direction of P-and S-wave propagation, which presents high consistency to double couple model of the fault slip. On this basis, the comparison with the design scaling law formulas proposed by Kaiser and associates finds that the existing design scaling law does not totally satisfy the demand of practical engineering. Numerical calculation and analysis with the three dimensional discrete model can further optimize the support parameters, provide better service for system design of mining support, and ensure the safety and high efficiency in mining.
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| 2. |
- Dong, Zhen, et al.
(author)
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Mitoepigenetics and Its Emerging Roles in Cancer
- 2020
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In: Frontiers in Cell and Developmental Biology. - : Frontiers Media S.A.. - 2296-634X. ; 8
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Research review (peer-reviewed)abstract
- In human beings, there is a similar to 16,569 bp circular mitochondrial DNA (mtDNA) encoding 22 tRNAs, 12S and 16S rRNAs, 13 polypeptides that constitute the central core of ETC/OxPhos complexes, and some non-coding RNAs. Recently, mtDNA has been shown to have some covalent modifications such as methylation or hydroxylmethylation, which play pivotal epigenetic roles in mtDNA replication and transcription. Posttranslational modifications of proteins in mitochondrial nucleoids such as mitochondrial transcription factor A (TFAM) also emerge as essential epigenetic modulations in mtDNA replication and transcription. Post-transcriptional modifications of mitochondrial RNAs (mtRNAs) including mt-rRNAs, mt-tRNAs and mt-mRNAs are important epigenetic modulations. Besides, mtDNA or nuclear DNA (n-DNA)-derived non-coding RNAs also play important roles in the regulation of translation and function of mitochondrial genes. These evidences introduce a novel concept of mitoepigenetics that refers to the study of modulations in the mitochondria that alter heritable phenotype in mitochondria itself without changing the mtDNA sequence. Since mitochondrial dysfunction contributes to carcinogenesis and tumor development, mitoepigenetics is also essential for cancer. Understanding the mode of actions of mitoepigenetics in cancers may shade light on the clinical diagnosis and prevention of these diseases. In this review, we summarize the present study about modifications in mtDNA, mtRNA and nucleoids and modulations of mtDNA/nDNA-derived non-coding RNAs that affect mtDNA translation/function, and overview recent studies of mitoepigenetic alterations in cancer.
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