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Träfflista för sökning "WFRF:(Dou Hao Wen) "

Search: WFRF:(Dou Hao Wen)

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1.
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2.
  • Lv, Yi Qing, et al. (author)
  • Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model
  • 2022
  • In: Translational Neurodegeneration. - : Springer Science and Business Media LLC. - 2047-9158. ; 11
  • Journal article (peer-reviewed)abstract
    • Background: Growing evidence suggests an association between Parkinson’s disease (PD) and diabetes mellitus (DM). At the cellular level, long-term elevated levels of glucose have been shown to lead to nigrostriatal degeneration in PD models. However, the underlying mechanism is still unclear. Previously, we have elucidated the potential of type 2 diabetes mellitus (T2DM) in facilitating PD progression, involving aggregation of both alpha-synuclein (α-syn) and islet amyloid polypeptide in the pancreatic and brain tissues. However, due to the complicated effect of insulin resistance on PD onset, the actual mechanism of hyperglycemia-induced dopaminergic degeneration remains unknown. Methods: We employed the type 1 diabetes mellitus (T1DM) model induced by streptozotocin (STZ) injection in a transgenic mouse line (BAC-α-syn-GFP) overexpressing human α-syn, to investigate the direct effect of elevated blood glucose on nigrostriatal degeneration. Results: STZ treatment induced more severe pathological alterations in the pancreatic islets and T1DM symptoms in α-syn-overexpressing mice than in wild-type mice, at one month and three months after STZ injections. Behavioral tests evaluating motor performance confirmed the nigrostriatal degeneration. Furthermore, there was a marked decrease in dopaminergic profiles and an increase of α-syn accumulation and Serine 129 (S129) phosphorylation in STZ-treated α-syn mice compared with the vehicle-treated mice. In addition, more severe neuroinflammation was observed in the brains of the STZ-treated α-syn mice. Conclusion: Our results solidify the potential link between DM and PD, providing insights into how hyperglycemia induces nigrostriatal degeneration and contributes to pathogenic mechanisms in PD.
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3.
  • Ablikim, M., et al. (author)
  • Amplitude analysis of D0 → K -π+π+π-
  • 2017
  • In: Physical Review D. - 2470-0010 .- 2470-0029. ; 95:7
  • Journal article (peer-reviewed)abstract
    • We present an amplitude analysis of the decay D0 → K -π+π+π- based on a data sample of 2.93  fb−1 acquired by the BESIII detector at the ψ(3770) resonance. With a nearly background free sample of about 16000 events, we investigate the substructure of the decay and determine the relative fractions and the phases among the different intermediate processes. Our amplitude model includes the two-body decays D0 → ¯K*0ρ0, D0 → K−a+1(1260) and D0 → K−1(1270)π+, the three-body decays D0 →¯K*0π+π− and D0 → K−π+ρ0, as well as the four-body nonresonant decay D0 → K−π+π+π−. The dominant intermediate process is D0 → K−a+1(1260), accounting for a fit fraction of 54.6%.
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4.
  • Ablikim, M., et al. (author)
  • Amplitude analysis of the chi(c1) -> eta pi(+)pi(-) decays
  • 2017
  • In: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 95:3
  • Journal article (peer-reviewed)abstract
    • Using 448.0 x 10(6) psi(3686) events collected with the BESIII detector, an amplitude analysis is performed for psi(3686) -> gamma chi(c1), chi(c1) ->eta pi(+)pi(-) decays. The most dominant two- body structure observed is a(0)(980)(+/-) pi(-/+); a(0)(980)(+/-) -> eta pi(+/-.) line shape is modeled using a dispersion relation, and a significant nonzero a(0) (980) coupling to the eta'pi channel is measured. We observe chi(c1) -> a(2)(1700)pi production for the first time, with a significance larger than 17 sigma. The production of mesons with exotic quantum numbers, J(PC) = 1(-+), is investigated, and upper limits for the branching fractions chi(c1) -> pi(1)(1400)(+/-)pi(-/+) , chi(c1) -> pi(1)(1600)(+/-)pi(-/+) and chi(c1) -> pi 1(2015)(+/-)pi(-/+) with subsequent pi(1)(X)(+/-) -> eta pi(+/-) decay, are determined.
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5.
  • Ablikim, M., et al. (author)
  • Amplitude Analysis of the Decays eta ' -> pi(+)pi(-)pi(0) and eta' -> pi(0)pi(0)pi(0)
  • 2017
  • In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 118:1
  • Journal article (peer-reviewed)abstract
    • Based on a sample of 1.31 x 10(9) J/Psi events collected with the BESIII detector, an amplitude analysis of the isospin-violating decays eta' -> pi(+)pi(-)pi(0) and eta' -> pi(0)pi(0)pi(0) is performed. A significant P-wave contribution from eta' -> rho(+/-)eta(-/+) is observed for the first time in eta' -> pi(+)pi(-)pi(0). The branching fraction is determined to be B(eta' -> rho(+/-)pi(-/+)) = (7.44 +/- 0.60 +/- 1.26 +/- 1.84) x 10(-4), where the first uncertainty is statistical, the second systematic, and the third model dependent. In addition to the nonresonant S-wave component, there is a significant sigma meson component. The branching fractions of the combined S-wave components are determined to be B(eta' -> pi(+)pi(-)pi(0))(S) = (37.63 +/- 0.77 +/- 2.22 +/- 4.48) x 10(-4) and B(eta' -> pi(0)pi(0)pi(0)) = (35.22 +/- 0.82 +/- 2.54) x 10(-4), respectively. The latter one is consistent with previous BESIII measurements.
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6.
  • Ablikim, M., et al. (author)
  • Amplitude analysis of the KSKS system produced in radiative J /psi decays
  • 2018
  • In: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 98:7
  • Journal article (peer-reviewed)abstract
    • An amplitude analysis of the KSKS system produced in radiative J/psi decays is performed using the (1310.6 +/- 7.0) x 10(6) nip decays collected by the BESIII detector. Two approaches are presented. A mass-dependent analysis is performed by parametrizing the KSKS invariant mass spectrum as a sum of Breit-aligner line shapes. Additionally, a mass-independent analysis is performed to extract a piecewise function that describes the dynamics of the KSKS system while making minimal assumptions about the properties and number of poles in the amplitude. The dominant amplitudes in the mass-dependent analysis include the f(0)(1710), f(0)(2200), and f(2)'(1525). The mass-independent results, which are made available as input for further studies, are consistent with those of the mass-dependent analysis and are useful for a systematic study of hadronic interactions. The branching fraction of radiative J/psi decays to KSKS is measured to be (8.1 +/- 0.4) x 10(-4), where the uncertainty is systematic and the statistical uncertainty is negligible.
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7.
  • Ablikim, M., et al. (author)
  • Analysis of D+ -> (K)over-bar(0)e(+)nu(e) and D+ -> pi(0)e(+)nu(e) semileptonic decays
  • 2017
  • In: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 96:1
  • Journal article (peer-reviewed)abstract
    • Using 2.93 fb(-1) of data taken at 3.773 GeV with the BESIII detector operated at the BEPCII collider, we study the semileptonic decays D+ -> (K) over bar (0)e(+)nu(e) and D+ -> pi(0)e(+)nu(e). We measure the absolute decay branching fractions B(D+ -> (K) over bar (0)e(+)nu(e)) = (8.60 +/- 0.06 +/- 0.15) x 10(-2) and B(D+ -> pi(0)e(+)nu(e)) = (3.63 +/- 0.08 +/- 0.05) x 10(-3), where the first uncertainties are statistical and the second systematic. We also measure the differential decay rates and study the form factors of these two decays. With the values of |V-cs| and |V-cd| from Particle Data Group fits assuming Cabibbo-Kobayashi-Maskawa (CKM) unitarity, we obtain the values of the form factors at q(2) = 0, f(+)(K)(0) = 0.725 +/- 0.004 +/- 0.012, and f(+)(pi)(0) = 0.622 +/- 0.012 +/- 0.003. Taking input from recent lattice QCD calculations of these form factors, we determine values of the CKM matrix elements |V-cs| = 0.944 +/- 0.005 +/- 0.015 +/- 0.024 and |V-cd| = 0.210 +/- 0.004 +/- 0.001 +/- 0.009, where the third uncertainties are theoretical.
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8.
  • Ablikim, M., et al. (author)
  • Branching fraction measurement of J/ψ→KSKL and search for J/ψ→KSKS
  • 2017
  • In: Physical Review D. - 2470-0010 .- 2470-0029. ; 96:11
  • Journal article (peer-reviewed)abstract
    • Using a sample of 1.31 x 10(9) J/Psi events collected with the BESIII detector at the BEPCII collider, we study the decays of J/Psi -> KSKL and KSKS. The branching fraction of J/Psi -> KSKL is determined to be B(J/Psi -> KSKL) = (1.93 +/- 0.01 (stat) +/- 0.05 (syst)) x 10(-4), which significantly improves on previous measurements. No clear signal is observed for the J/Psi -> KSKS process, and the upper limit at the 95% confidence level for its branching fraction is determined to be B(J/Psi -> KSKS) < 1.4 x 10(-8), which improves on the previous searches by 2 orders in magnitude and reaches the order of the Einstein-Podolsky-Rosen expectation.
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9.
  • Ablikim, M., et al. (author)
  • Branching fraction measurements of psi (3686) -> gamma chi(cJ)
  • 2017
  • In: Physical Review D. - 2470-0010 .- 2470-0029. ; 96:3
  • Journal article (peer-reviewed)abstract
    • Using a sample of 106 million psi(3686) decays, the branching fractions of psi(3686) -> gamma chi(c0), psi(3686) -> gamma chi(c1), and psi(3686) -> gamma chi(c2) are measured with improved precision to be (9.389 +/- 0.014 +/- 0.332) %, (9.905 +/- 0.011 +/- 0.353) %, and (9.621 +/- 0.013 +/- 0.272) %, respectively, where the first uncertainties are statistical and the second ones are systematic. The product branching fractions of (psi 3686) -> gamma chi(c1), chi(c1) -> gamma J/psi (3686) -> gamma chi(c2), chi(c2) -> gamma J/psi and the branching fractions of chi(c1) -> gamma J/psi and chi(c2) -> gamma J/psi are also presented.
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10.
  • Ablikim, M., et al. (author)
  • Determination of the number of J/psi events with inclusive J/psi decays
  • 2017
  • In: Chinese Physics C. - : IOP Publishing. - 1674-1137 .- 2058-6132. ; 41:1
  • Journal article (peer-reviewed)abstract
    • A measurement of the number of J/psi events collected with the BESIII detector in 2009 and 2012 is performed using inclusive decays of the J/psi. The number of J/psi events taken in 2009 is recalculated to be (223.7 +/- 1.4) x 10(6), which is in good agreement with the previous measurement, but with significantly improved precision due to improvements in the BESIII software. The number of J/psi events taken in 2012 is determined to be (1086.9 +/- 6.0) x 10(6). In total, the number of J/psi events collected with the BESIII detector is measured to be (1310.6 +/- 7.0) x 10(6), where the uncertainty is dominated by systematic effects and the statistical uncertainty is negligible.
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  • Result 1-10 of 83

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