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- Wilkinson, JD, et al.
(author)
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Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000)
- 2002
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In: Contact Dermatitis. - : Wiley. - 0105-1873. ; 46:4, s. 207-210
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Journal article (peer-reviewed)abstract
- A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.
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