SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Edlund G.) "

Search: WFRF:(Edlund G.)

  • Result 1-10 of 154
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Jiang, X., et al. (author)
  • Shared heritability and functional enrichment across six solid cancers
  • 2019
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
  • Journal article (peer-reviewed)abstract
    • Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  • Chen, Zhishan, et al. (author)
  • Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
  • 2024
  • In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
  • Journal article (peer-reviewed)abstract
    • Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-10 of 154
Type of publication
journal article (121)
review (11)
conference paper (7)
other publication (6)
research review (4)
book chapter (2)
show more...
editorial collection (1)
reports (1)
editorial proceedings (1)
show less...
Type of content
peer-reviewed (118)
other academic/artistic (34)
pop. science, debate, etc. (2)
Author/Editor
Edlund, K. (16)
Edlund, Karolina (15)
Edlund, C (14)
Micke, Patrick (13)
Hengstler, Jan G. (13)
Wadell, G (12)
show more...
Delsing, Lars-Olof (11)
Botling, Johan (10)
Pontén, Fredrik (9)
Rylander, E (9)
Johansson, Karl G. (8)
Evander, M. (7)
Conti, DV (7)
Edlund, Lars-Erik (7)
Edlund, CK (7)
Edlund, Jens, Docent ... (7)
Edlund, M. (7)
Hellwig, Birte (7)
Chanock, Stephen J (6)
Giles, Graham G (6)
Edlund, Charlotta (6)
Ekman, Simon (6)
Albanes, D (6)
Weinstein, S (6)
Offit, K. (6)
Edlund, Christopher ... (6)
Edlund, G (6)
Li, L. (5)
Zheng, W. (5)
Brenner, H (5)
Chang-Claude, Jenny (5)
Edlund, Ulrica, 1972 ... (5)
White, E (5)
Wolk, Alicja (5)
Berndt, Sonja I (5)
Conti, David V (5)
Albanes, Demetrius (5)
Chang-Claude, J (5)
Jirström, Karin (5)
Offit, Kenneth (5)
Southey, Melissa C. (5)
Koyi, Hirsh (5)
Brandén, Eva (5)
Kraft, P (5)
Hunter, David J (5)
Casey, G (5)
Hedin, Katarina (5)
Brunnström, Hans (5)
Mattsson, Johanna So ... (5)
Peters, U (5)
show less...
University
Karolinska Institutet (69)
Uppsala University (44)
Lund University (27)
Umeå University (24)
Royal Institute of Technology (19)
University of Gothenburg (17)
show more...
Linköping University (8)
Örebro University (7)
Chalmers University of Technology (5)
Stockholm University (3)
Mid Sweden University (3)
Södertörn University (3)
Luleå University of Technology (2)
Stockholm School of Economics (2)
Mälardalen University (1)
University of Skövde (1)
Linnaeus University (1)
RISE (1)
Högskolan Dalarna (1)
show less...
Language
English (139)
Swedish (15)
Research subject (UKÄ/SCB)
Medical and Health Sciences (48)
Natural sciences (28)
Humanities (16)
Engineering and Technology (4)
Social Sciences (2)
Agricultural Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view