| 1. |
- Devarakonda, Sravani, et al.
(author)
-
Low-grade intestinal inflammation two decades after pelvic radiotherapy.
- 2023
-
In: EBioMedicine. - 2352-3964. ; 94
-
Journal article (peer-reviewed)abstract
- Radiotherapy is effective in the treatment of cancer but also causes damage to non-cancerous tissue. Pelvic radiotherapy may produce chronic and debilitating bowel symptoms, yet the underlying pathophysiology is still undefined. Most notably, although pelvic radiotherapy causes an acute intestinal inflammation there is no consensus on whether the late-phase pathophysiology contains an inflammatory component or not. To address this knowledge gap, we examined the potential presence of a chronic inflammation in mucosal biopsies from irradiated pelvic cancer survivors.We biopsied 24 cancer survivors two to 20 years after pelvic radiotherapy, and four non-irradiated controls. Using tandem mass tag (TMT) mass spectrometry and mRNA sequencing (mRNA-seq), we charted proteomic and transcriptomic profiles of the mucosal tissue previously exposed to a high or a low/no dose of radiation. Changes in the immune cell populations were determined with flow cytometry. The integrity of the protective mucus layers were determined by permeability analysis and 16S rRNA bacterial detection.942 proteins were differentially expressed in mucosa previously exposed to a high radiation dose compared to a low radiation dose. The data suggested a chronic low-grade inflammation with neutrophil activity, which was confirmed by mRNA-seq and flow cytometry and further supported by findings of a weakened mucus barrier with bacterial infiltration.Our results challenge the idea that pelvic radiotherapy causes an acute intestinal inflammation that either heals or turns fibrotic without progression to chronic inflammation. This provides a rationale for exploring novel strategies to mitigate chronic bowel symptoms in pelvic cancer survivors.This study was supported by the King Gustav V Jubilee Clinic Cancer Foundation (CB), The Adlerbertska Research Foundation (CB), The Swedish Cancer Society (GS), The Swedish State under the ALF agreement (GS and CB), Mary von Sydow's foundation (MA and VP).
|
|
| 2. |
- Ekh, Johan, et al.
(author)
-
Secondary Bending in Multi Fastener, Composite-to-Aluminium Single Shear Lap Joints
- 2005
-
In: Composites Part B. - : Elsevier BV. - 1359-8368 .- 1879-1069. ; 36, s. 195-208
-
Journal article (peer-reviewed)abstract
- A novel technique to study secondary bending due to the eccentric load path in single shear, composite-to-aluminium lap joints has been developed and used in a parametric study. The method is based on the specimen curvature, which is derived from lateral displacements of the surface. The lateral displacements are measured with an optical measurement system or calculated with the finite element method. It was found that the specimen curvature is equivalent to the secondary bending which is usually measured with strain gauges in the vicinity of the bolt holes. The two most important parameters affecting specimen curvature is the overlap length and the thickness of the aluminium plate in the joints.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Hugelius, Karin, 1977-, et al.
(author)
-
Vital and Clinical Signs Gathered Within the First Minutes After a Motorcycle Accident on a Racetrack: an Observational Study
- 2021
-
In: Sports Medicine-Open. - : Springer Science and Business Media LLC. - 2199-1170 .- 2198-9761 .- 0112-1642 .- 1179-2035. ; 7:1
-
Journal article (peer-reviewed)abstract
- Background Little is known about vital signs during the very first minutes after an accident. This study aimed to describe the vital signs of motorcycle riders shortly after racetrack crashes and examine the clinical value of these data for the prehospital clinical assessments. Methods A retrospective observational cohort based on data from medical records on 104 motorcycle accidents at a racetrack in Sweden, covering the season of 2019 (May 01 until September 17), was conducted. Both race and practice runs were included. In addition, data from the Swedish Trauma Registry were used for patients referred to the hospital. Kruskal-Wallis test and linear regression were calculated in addition to descriptive statistics. Results In all, 30 riders (29%) were considered injured. Sixteen riders (15%) were referred to the hospital, and of these, five patients (5% of all riders) had suffered serious injuries. Aside from a decreased level of consciousness, no single vital sign or kinematic component observed within the early minutes after a crash was a strong clinical indicator of the occurrence of injuries. However, weak links were found between highsider or collision crashes and the occurrence of injuries. Conclusion Except for a decreased level of consciousness, this study indicates that the clinical value of early measured vital signs might be limited for the pre-hospital clinical assessment in the motorsport environment. Also, an adjustment of general trauma triage protocols might be considered for settings such as racetracks. Using the context with medical professionals at the victim's side within a few minutes after an accident, that is common in motorsport, offers unique possibilities to increase our understanding of clinical signs and trauma in the early state after an accident.
|
|
| 6. |
|
|
