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- Lappi, Emma
(author)
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Post-entrepreneurship productivity
- 2020
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Doctoral thesis (other academic/artistic)abstract
- In recent decades, public policies have been implemented to encourage individuals to become entrepreneurs. However, the individual and social benefits of such policies when some of these individuals eventually leave entrepreneurship are unclear. The purpose of this thesis is to empirically assess the productivity effects arising from the labor market experience of entrepreneurship, measured as self-employment, in subsequent wage employment.This thesis consists of an introductory chapter and four independent papers. The four papers evaluate the consequences of the self-employment experience either for the individuals’ wages or for firm productivity when firms hire such individuals. All the papers compare the self-employment experience relative to wage employment.The first paper estimates how individuals’ earnings are influenced in post-entrepreneurship careers when they return to wage employment. The findings suggest that former entrepreneurs suffer large earnings losses, especially in the first year as employees, and for the higher educated, these losses persist even after seven years in employment. The second paper studies the role of professional ties in entry wages when finding employment after self-employment. The results show that even when using former coworker ties in the hiring process, the former self-employed, except for those who have ties with incumbent employees when they had their own firm, earn significantly lower entry wages.The third paper evaluates the productivity effects of different labor flows, with an emphasis on hiring former entrepreneurs. The paper finds that new hires who come from entrepreneurship, in general, are just as productive as those employees hired from another firm but are more productive than those coming from unemployment. The fourth paper analyzes how having employees with former entrepreneurship experience is related to firm productivity. The results show that having more former entrepreneurs as employees in a firm increases performance.
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- Locke, Adam E, et al.
(author)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Journal article (peer-reviewed)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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- Shungin, Dmitry, et al.
(author)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Journal article (peer-reviewed)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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- Ytterberg, A Jimmy, et al.
(author)
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Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis : identification and validation
- 2015
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In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 74:9, s. 1772-1777
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Journal article (peer-reviewed)abstract
- OBJECTIVES: Immunological events in the lungs might trigger production of anti-citrullinated protein antibodies during early rheumatoid arthritis (RA). We investigated the presence of shared immunological citrullinated targets in joints and lungs of patients with RA.PATIENTS AND METHODS: Proteins extracted from bronchial (n=6) and synovial (n=7) biopsy specimens from patients with RA were investigated by mass spectrometry-based proteomics. One candidate peptide was synthesised and used to investigate by ELISA the presence of antibodies in patients with RA (n=393), healthy controls (n=152) and disease controls (n=236). HLA-DRB1 shared epitope (SE) alleles were detected in patients with RA.RESULTS: Ten citrullinated peptides belonging to seven proteins were identified, with two peptides shared between the synovial and bronchial biopsy samples. Further analysis, using accurate mass and retention time, enabled detection of eight citrullinated peptides in synovial and seven in bronchial biopsy specimens, with five peptides shared between the synovial and bronchial biopsy specimens. Two citrullinated vimentin (cit-vim) peptides were detected in the majority of synovial and lung tissues. Antibodies to a synthesised cit-vim peptide candidate (covering both cit-vim peptides identified in vivo) were present in 1.8% of healthy controls, 15% of patients with RA, and 3.4% of disease controls. Antibodies to cit-vim peptide were associated with the presence of the SE alleles in RA.CONCLUSIONS: Identical citrullinated peptides are present in bronchial and synovial tissues, which may be used as immunological targets for antibodies of patients with RA. The data provide further support for a link between lungs and joints in RA and identify potential targets for immunity that may mediate this link.
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- Abbas, Muhammad Tahir, et al.
(author)
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Energy-Saving Solutions for Cellular Internet of Things - A Survey
- 2022
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In: IEEE Access. - IEEE : IEEE. - 2169-3536. ; 10, s. 62096-62096
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Journal article (peer-reviewed)abstract
- The Cellular Internet of Things (CIoT), a new paradigm, paves the way for a large-scale deployment of IoT devices. CIoT promises enhanced coverage and massive deployment of low-cost IoT devices with an expected battery life of up to 10 years. However, such a long battery life can only be achieved provided the CIoT device is configured with energy efficiency in mind. This paper conducts a comprehensive survey on energy-saving solutions in 3GPP-based CIoT networks. In comparison to current studies, the contribution of this paper is the classification and an extensive analysis of existing energy-saving solutions for CIoT, e.g., the configuration of particular parameter values and software modifications of transport- or radio-layer protocols, while also stressing key parameters impacting the energy consumption such as the frequency of data reporting, discontinuous reception cycles (DRX), and Radio Resource Control (RRC) timers. In addition, we discuss shortcomings, limitations, and possible opportunities which can be investigated in the future to reduce the energy consumption of CIoT devices.
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- Abbas, Muhammed Tahir, et al.
(author)
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Evaluating the Impact of Pre-Configured Uplink Resources in Narrowband IoT
- 2024
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In: Sensors. - Switzerland. - 1424-8220. ; 24:17
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Journal article (peer-reviewed)abstract
- Deploying Cellular Internet of Things (CIoT) devices in urban and remote areas faces significant energy efficiency challenges. This is especially true for Narrowband IoT (NB-IoT) devices, which are expected to function on a single charge for up to 10 years while transmitting small amounts of data daily. The 3rd Generation Partnership Project (3GPP) has introduced energy-saving mechanisms in Releases 13 to 16, including Early Data Transmission (EDT) and Preconfigured Uplink Resources (PURs). These mechanisms extend battery life and reduce latency by enabling data transmission without an active Radio Resource Control (RRC) connection or Random Access Procedure (RAP). This paper examines these mechanisms using the LENA-NB simulator in the ns-3 environment, which is a comprehensive framework for studying various aspects of NB-IoT. The LENA-NB has been extended with PURs, and our analysis shows that PURs significantly enhance battery life and latency efficiency, particularly in high-density environments. Compared to the default RAP method, PURs reduce energy consumption by more than 2.5 times and increases battery life by 1.6 times. Additionally, PURs achieve latency reductions of 2.5 - 3.5 times. The improvements with PURs are most notable for packets up to 125 bytes. Our findings highlight PURs' potential to enable more efficient and effective CIoT deployments across various scenarios. This study represents a detailed analysis of latency and energy consumption in a simulated environment, advancing the understanding of PURs' benefits.
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- Abbas, Muhammad Tahir, et al.
(author)
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Guidelines for an Energy Efficient Tuning of the NB-IoT Stack
- 2020
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In: 45th IEEE Conference on Local Computer Networks (LCN). - : IEEE Communications Society. ; , s. 60-69
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Conference paper (peer-reviewed)abstract
- In this paper, we study the energy consumptionof Narrowband IoT devices. The paper suggests that key tosaving energy for NB-IoT devices is the usage of full Discontinuous Reception (DRX), including the use of connected-mode DRX (cDRX): In some cases, cDRX reduced the energy consumption over a 10-year period with as much as 50%. However, the paper also suggests that tunable parameters, such as the inactivity timer, do have a significant impact. On the basis of our findings, guidelines are provided on how to tune the NB-IoT device so that it meets the target of the 3GPP, i.e., a 5-Wh battery should last for at least 10 years. It is further evident from our results that the energy consumption is largely dependent on the intensity and burstiness of the traffic, and thus could be significantly reduced if data is sent in bursts with less intensity,irrespective of cDRX support.
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| 10. |
- Abbas, Muhammad Tahir, et al.
(author)
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Impact of Tunable Parameters in NB-IoT Stack onthe Energy Consumption
- 2019
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In: Proceedings of Fifteenth Swedish National Computer Networking Workshop (SNCNW).
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Conference paper (peer-reviewed)abstract
- This paper studies the impact of tunable parametersin the NB-IoT stack on the energy consumption of a user equipment(UE), e.g., a wireless sensor. NB-IoT is designed to enablemassive machine-type communications for UE while providing abattery lifetime of up to 10 years. To save battery power, most oftime the UE is in dormant state and unreachable. Still, duringthe CONNECTED and IDLE state, correct tuning of criticalparameters, like Discontinuous reception (DRX), and extendedDiscontinuous reception (eDRX), respectively, are essential to savebattery power. Moreover, the DRX and eDRX actions relate tovarious parameters which are needed to be tuned in order toachieve a required UE battery lifetime. The objective of thispaper is to observe the influence of an appropriate tuning ofthese parameters to reduce the risk of an early battery drainage
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