| 1. |
- Ive, Anders, et al.
(author)
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Garbage collector interface
- 2002
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In: Proceedings of the Tenth Nordic Workshop on Programming and Software Development Tools and Techniques (NWPER 2002).
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Conference paper (peer-reviewed)abstract
- The purpose of the presented garbage collector interface is to provide a universal interface for many different implementations of garbage collectors. This is to simplify the integration and exchange of garbage collectors, but also to support incremental, non-conservative, and thread safe implementations. Due to the complexity of the interface, it is aimed at code generators and preprocessors. Experiences from ongoing implementations indicate that the garbage collector interface successfully provides the necessary functionality in an efficient way,
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| 2. |
- Bill-Axelson, Anna, et al.
(author)
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Radical prostatectomy versus watchful waiting in localized prostate cancer : the Scandinavian prostate cancer group-4 randomized trial
- 2008
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In: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 100:16, s. 1144-1154
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Journal article (peer-reviewed)abstract
- BACKGROUND: The benefit of radical prostatectomy in patients with early prostate cancer has been assessed in only one randomized trial. In 2005, we reported that radical prostatectomy improved prostate cancer survival compared with watchful waiting after a median of 8.2 years of follow-up. We now report results after 3 more years of follow-up.METHODS: From October 1, 1989, through February 28, 1999, 695 men with clinically localized prostate cancer were randomly assigned to radical prostatectomy (n = 347) or watchful waiting (n = 348). Follow-up was complete through December 31, 2006, with histopathologic review and blinded evaluation of causes of death. Relative risks (RRs) were estimated using the Cox proportional hazards model. Statistical tests were two-sided.RESULTS: During a median of 10.8 years of follow-up (range = 3 weeks to 17.2 years), 137 men in the surgery group and 156 in the watchful waiting group died (P = .09). For 47 of the 347 men (13.5%) who were randomly assigned to surgery and 68 of the 348 men (19.5%) who were not, death was due to prostate cancer. The difference in cumulative incidence of death due to prostate cancer remained stable after about 10 years of follow-up. At 12 years, 12.5% of the surgery group and 17.9% of the watchful waiting group had died of prostate cancer (difference = 5.4%, 95% confidence interval [CI] = 0.2 to 11.1%), for a relative risk of 0.65 (95% CI = 0.45 to 0.94; P = .03). The difference in cumulative incidence of distant metastases did not increase beyond 10 years of follow-up. At 12 years, 19.3% of men in the surgery group and 26% of men in the watchful waiting group had been diagnosed with distant metastases (difference = 6.7%, 95% CI = 0.2 to 13.2%), for a relative risk of 0.65 (95% CI = 0.47 to 0.88; P = .006). Among men who underwent radical prostatectomy, those with extracapsular tumor growth had 14 times the risk of prostate cancer death as those without it (RR = 14.2, 95% CI = 3.3 to 61.8; P < .001).CONCLUSION: Radical prostatectomy reduces prostate cancer mortality and risk of metastases with little or no further increase in benefit 10 or more years after surgery.
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| 3. |
- Ekman, Annica M. L., et al.
(author)
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Impact of Two-Way Aerosol-Cloud Interaction and Changes in Aerosol Size Distribution on Simulated Aerosol-Induced Deep Convective Cloud Sensitivity
- 2011
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In: Journal of the Atmospheric Sciences. - 0022-4928 .- 1520-0469. ; 68:4, s. 685-698
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Journal article (peer-reviewed)abstract
- Recent cloud-resolving model studies of single (isolated) deep convective clouds have shown contradicting results regarding the response of the deep convection to changes in the aerosol concentration. In the present study, a cloud-resolving model including explicit aerosol physics and chemistry is used to examine how the complexity of the aerosol model, the size of the aerosols, and the aerosol activation parameterization influence the aerosol-induced deep convective cloud sensitivity. Six sensitivity series are conducted. A significant difference in the aerosol-induced deep convective cloud sensitivity is found when using different complexities of the aerosol model and different aerosol activation parameterizations. In particular, graupel impaction scavenging of aerosols appears to be a crucial process because it efficiently may limit the number of cloud condensation nuclei (CCN) at a critical stage of cloud development and thereby dampen the convection. For the simulated case, a 100% increase in aerosol concentration results in a difference in average updraft between the various sensitivity series that is as large as the average updraft increase itself. The change in graupel and rain formation also differs significantly. The sign of the change in precipitation is not always directly proportional to the change in updraft velocity and several of the sensitivity series display a decrease of the rain amount with increasing updraft velocity. This result illustrates the need to account for changes in evaporation processes and subsequent cooling when assessing aerosol effects on deep convective strength. The model simulations also show that an increased number of aerosols in the Aitken mode (here defined by 23 <= d <= 100.0 nm) results in a larger impact on the convective strength compared to an increased number of aerosols in the accumulation mode (here defined by 100 <= d <= 900.0 nm). When accumulation mode aerosols are activated and grow at the beginning of the cloud cycle, the supersaturation near the cloud base is lowered, which to some extent limits further aerosol activation. The simulations indicate a need to better understand and represent the two-way interaction between aerosols and clouds when studying aerosol-induced deep convective cloud sensitivity.
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| 4. |
- Ekman, Urban, et al.
(author)
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Increase of frontal neuronal activity in chronic neglect after training in virtual reality
- 2018
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In: Acta Neurologica Scandinavica. - : John Wiley & Sons. - 0001-6314 .- 1600-0404. ; 138:4, s. 284-292
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Journal article (peer-reviewed)abstract
- Objectives: A third of patients with stroke acquire spatial neglect associated with poor rehabilitation outcome. New effective rehabilitation interventions are needed. Scanning training combined with multisensory stimulation to enhance the rehabilitation effect is suggested. In accordance, we have designed a virtual-reality based scanning training that combines visual, audio and sensori-motor stimulation called RehAtt((R)). Effects were shown in behavioural tests and activity of daily living. Here, we use fMRI to evaluate the change in brain activity during Posners Cuing Task (attention task) after RehAtt((R)) intervention, in patients with chronic neglect.Methods: Twelve patients (mean age=72.7years, SD=6.1) with chronic neglect (persistent symptoms >6months) performed the interventions 3 times/wk during 5weeks, in total 15hours. Training effects on brain activity were evaluated using fMRI task-evoked responses during the Posners cuing task before and after the intervention.Results: Patients improved their performance in the Posner fMRI task. In addition, patients increased their task-evoked brain activity after the VR interventions in an extended network including pre-frontal and temporal cortex during attentional cueing, but showed no training effects during target presentations.Conclusions: The current pilot study demonstrates that a novel multisensory VR intervention has the potential to benefit patients with chronic neglect in respect of behaviour and brain changes. Specifically, the fMRI results show that strategic processes (top-down control during attentional cuing) were enhanced by the intervention. The findings increase knowledge of the plasticity processes underlying positive rehabilitation effects from RehAtt((R)) in chronic neglect.
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| 5. |
- Kans, Mirka, 1971-, et al.
(author)
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Data Driven Maintenance : A Promising Way of Action for Future Industrial Services Management
- 2022
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In: International Congress and Workshop on Industrial AI 2021. IAI 2021. - Cham : Springer. - 9783030936389 - 9783030936396 ; , s. 212-223, s. 212-223
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Conference paper (peer-reviewed)abstract
- Maintenance and services of products as well as processes are pivotal for achieving high availability and avoiding catastrophic and costly failures. At the same time, maintenance is routinely performed more frequently than necessary, replacing possibly functional components, which has negative economic impact on the maintenance. New processes and products need to fulfil increased environmental demands, while customers put increasing demands on customization and coordination. Hence, improved maintenance processes possess very high potentials, economically as well as environmentally. The shifting demands on product development and production processes have led to the emergency of new digital solutions as well as new business models, such as integrated product-service offerings. Still, the general maintenance problem of how to perform the right service at the right time, taking available information and given limitations is valid.The project Future Industrial Services Management (FUSE) project was a step in a long-term effort for catalysing the evolution of maintenance and production in the current digital era. In this paper, several aspects of the general maintenance problem are discussed from a data driven perspective, spanning from technology solutions and organizational requirements to new business opportunities and how to create optimal maintenance plans. One of the main results of the project, in the form of a simulation tool for strategy selection, is also described.
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| 6. |
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| 7. |
- Kågedal, Bertil, 1943-, et al.
(author)
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Determination of glomerular filtration rate, a spin off aftercontrast-enhanced computed tomography among criticallyill patients − proof of concept
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Other publication (other academic/artistic)abstract
- Background Recently, Gong et al. (Gong et al. 2022) showed, in nine heathy subjects, that plasma clearance of high doses of iohexol given as contrast enhanced computed tomography (CT) could be used for determination of glomerular filtration rate (GFR). We utilized high doses of iohexol from angiographic or other contrast enhanced CT given to critical ill patients for calculation of GFRiohexol and compared these data with standard low dose iohexol GFR determinations.Method Patients at intensive care units (ICUs) in Southeast Sweden intended for radiographic investigations that included injection of 45-120 ml of iohexol (Omnipaque) were included, and the concentration of iohexol in plasma was measured by HPLC. Iohexol clearance was calculated by the method of Bröchner-Mortensen. The following days was iohexol clearance determined using the standard low dose of 5 mL of iohexol. Sixteen patients admitted to ICUs were included in this pilot study.Results GFR after high dosing of iohexol at contrast enhanced CT could be measured for all sixteen critically ill patients. Patients with normal or increased renal function had neglectable iohexol concentrations the day following the CT scan. There was excellent correlation between GFR determination with high and standard low iohexol dosing among these 6 patients. Ten patients had decreased renal function and delayed elimination of iohexol, thus was not GFR measurement with low dose iohexol possible to analyse the day after CT scan with high dose iohexol.Conclusion This pilot study showed that GFR can be measured after high doses of iohexol at enhanced CT and compare well with the standard low dose of iohexol clearance determinations.
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| 8. |
- Leon, Otilia, et al.
(author)
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Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines
- 2014
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In: Radiotherapy and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 113:3, s. 352-358
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Journal article (peer-reviewed)abstract
- Objective:To evaluate treatment outcome in a large population-based cohort of patients with anal cancer treated according to Nordic guidelines.Material:Clinical data were collected on 1266 patients with anal squamous cell carcinoma diagnosed from 2000 to 2007 in Sweden, Norway and Denmark. 886 of the patients received radiotherapy 5464 Gy with or without chemotherapy (5-fluorouracil plus cisplatin or mitomycin). according to different protocols, stratified by tumor stage.Results:High age, male gender, large primary tumor, lymph node metastases, distant metastases, poor performance status, and non-inclusion into a protocol were all independent factors associated with worse outcome. Among patients treated according to any of the protocols, the 3-year recurrence-free survival ranged from 63% to 76%, with locoregional recurrences in 17% and distant metastases in 11% of patients. The highest rate of inguinal recurrence (11%) was seen in patients with small primary tumors, treated without inguinal irradiation.Conclusions:Good treatment efficacy was obtained with Nordic, widely implemented, guidelines for treatment of anal cancer. Inguinal prophylactic irradiation should be recommended also for small primary tumors. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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| 9. |
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| 10. |
- Micke, Patrick, et al.
(author)
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Gene Copy Number Aberrations Are Associated with Survival in Histologic Subgroups of Non-small Cell Lung Cancer
- 2011
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In: Journal of Thoracic Oncology. - 1556-0864 .- 1556-1380. ; 6:11, s. 1833-1840
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Journal article (peer-reviewed)abstract
- Introduction: Non-small cell lung cancer (NSCLC) is characterized by a multitude of genetic aberrations with unknown clinical impact. In this study, we aimed to identify gene copy number changes that correlate with clinical outcome in NSCLC. To maximize the chance to identify clinically relevant events, we applied a strategy involving two prognostically extreme patient groups. Methods: Short-term (<20 month; n = 53) and long-term survivors (>58 month; n = 47) were selected from a clinically well-characterized NSCLC patient cohort with available fresh frozen tumor specimens. The samples were analyzed using high-resolution single-nucleotide polymorphism array technology to assess gene copy number variations and array-based gene expression profiling. The molecular data were combined with information on clinical parameters. Results: Genetic aberrations were strongly associated with tumor histology. In adenocarcinoma (n = 50), gene copy number gains on chromosome 8q21-q24.3 (177 genes) were more frequent in long-term than in short-term survivors. In squamous cell carcinoma (n = 28), gains on chromosome 14q23.1-24.3 (133 genes) were associated with shorter survival, whereas losses in a neighboring region, 14q31.1-32.33 (110 genes), correlated with favorable outcome. In accordance with copy number gains and losses, messenger RNA expression levels of corresponding genes were increased or decreased, respectively. Conclusion: Comprehensive tumor profiling permits the integration of genomic, histologic, and clinical data. We identified gene copy number gains and losses, with corresponding changes in messenger RNA levels that were associated with prognosis in adenocarcinoma and squamous cell carcinoma of the lung.
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