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- Glasdam, Stinne, et al.
(author)
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A gap between the philosophy and the practice of palliative healthcare : sociological perspectives on the practice of nurses in specialised palliative homecare
- 2020
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In: Medicine, Health Care and Philosophy. - : Springer Science and Business Media LLC. - 1572-8633 .- 1386-7423. ; 23:1, s. 141-152
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Journal article (peer-reviewed)abstract
- Palliative care philosophy is based on a holistic approach to patients, but research shows that possibilities for living up to this philosophy seem limited by historical and administrative structures. From the nurse perspective, this article aims to explore nursing practice in specialised palliative homecare, and how it is influenced by organisational and cultural structures. Qualitative, semi-structured interviews with nine nurses were conducted, inspired by Bourdieu. The findings showed that nurses consolidate the doxa of medicine, including medical-professional values that configure a control-oriented, positivistic approach, supported by the organising policy for clinical practice. Hierarchically, nurses were positioned under doctors:medical rounds functioned as a structuring structure for their working day. They acted as medical assistants, and the prevailingmedical logic seemed to make it difficult for nurses to meet their own humanistic ideals. Only short time slots allowednurses to prioritise psychosocial needs of patients and relatives. Point-of-actions had high priority, added financial resourcesand ensured that budgets were allocated. Weekly visits made it possible for nurses to measure, control and govern patients’drugs and symptoms which was a necessity for their function as medical assistants. The findings challenge nurses to takeon an ethical point of view, partly to ensure that patients and their families receive good palliative care focusing on morethan medical issues and logic, and partly to strengthen the nurses’ profession in the palliative field and help them implementpalliative care philosophy in practice.
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| 2. |
- Rångtell, Frida H., et al.
(author)
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Two hours of evening reading on a self-luminous tablet vs. reading a physical book does not alter sleep after daytime bright light exposure
- 2016
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In: Sleep Medicine. - : Elsevier BV. - 1389-9457 .- 1878-5506. ; 23, s. 111-118
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Journal article (peer-reviewed)abstract
- Background: The use of electronic devices emitting blue light during evening hours has been associated with sleep disturbances in humans, possibly due to the blue light-mediated suppression of the sleep promoting hormone melatonin. However, experimental results have been mixed. The present study therefore sought to investigate if reading on a self-luminous tablet during evening hours would alter sleepiness, melatonin secretion, nocturnal sleep, as well as electroencephalographic power spectral density during early slow-wave sleep. Methods: Following a constant bright light exposure over 6.5 hours (similar to 569 lux), 14 participants (six females) read a novel either on a tablet or as physical book for two hours (21:00-23:00). Evening concentrations of saliva melatonin were repeatedly measured. Sleep (23:15-07:15) was recorded by polysomnography. Sleepiness was assessed before and after nocturnal sleep. About one week later, experiments were repeated; participants who had read the novel on a tablet in the first experimental session continued reading the same novel in the physical book, and vice versa. Results: There were no differences in sleep parameters and pre-sleep saliva melatonin levels between the tablet reading and physical book reading conditions. Conclusions: Bright light exposure during daytime has previously been shown to abolish the inhibitory effects of evening light stimulus on melatonin secretion. Our results could therefore suggest that exposure to bright light during the day - as in the present study - may help combat sleep disturbances associated with the evening use of electronic devices emitting blue light. However, this needs to be validated by future studies with larger sample populations.
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| 3. |
- Volpati, Diogo, et al.
(author)
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Monitoring the Intracellular Fate of Molecular Beacons : The Challenge of False Positive Signals
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In: Advanced NanoBiomed Research. - 2699-9307.
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Journal article (peer-reviewed)abstract
- Molecular beacons (MBs) have been used on surfaces for detecting oligonucleotides. Attempts to use them intracellularly for monitoring mRNA content have been made, however, without any clear conclusion regarding the reliability of the method, mainly due to false positive signals. To reach an understanding of the intracellular fate of MBs, a critical question remains: how long after MB delivery and where in the cell does a false positive signal appear? To answer that question, the MB delivery method should allow for a time-stamped synchronized delivery of MBs to multiple cells, resulting in MBs being distributed in the cytosol immediately after delivery. Herein, nanostraws are used to inject MBs targeting insulin (Ins1) mRNA directly in the cytosol of clonal beta-cells, and the evolution of the MB fluorescence in time and space is monitored. The results show an MB translocation to the nucleus, where MBs are degraded or where they open nonspecifically, before the fluorophore alone is expelled back from the nucleus to the cytosol. The signal translocation to the nucleus and back to the cytosol is faster when scrambled MBs are used. The results shed light on the intracellular fate of MBs and highlight the short time scales before false positive signals become predominant.
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