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  • Ehn, Sebastian, et al. (author)
  • X-ray deconvolution microscopy
  • 2016
  • In: Biomedical Optics Express. - 2156-7085. ; 7:4, s. 1227-1239
  • Journal article (peer-reviewed)abstract
    • Recent advances in single-photon-counting detectors are enabling the development of novel approaches to reach micrometer-scale resolution in x-ray imaging. One example of such a technology are the MEDIPIX3RX-based detectors, such as the LAMBDA which can be operated with a small pixel size in combination with real-time on-chip charge-sharing correction. This characteristic results in a close to ideal, box-like point spread function which we made use of in this study. The proposed method is based on raster-scanning the sample with sub-pixel sized steps in front of the detector. Subsequently, a deconvolution algorithm is employed to compensate for blurring introduced by the overlap of pixels with a well defined point spread function during the raster-scanning. The presented approach utilizes standard laboratory x-ray equipment while we report resolutions close to 10 mu m. The achieved resolution is shown to follow the relationship p/n with the pixel-size p of the detector and the number of raster-scanning steps n. (C) 2016 Optical Society of America
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Graafsma, Heinz (1)
Pfeiffer, Franz (1)
Pennicard, David (1)
Ehn, Sebastian (1)
Epple, Franz Michael (1)
Fehringer, Andreas (1)
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Noel, Peter (1)
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University
Mid Sweden University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Engineering and Technology (1)
Year

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