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Träfflista för sökning "WFRF:(Erb Tobias J.) "

Search: WFRF:(Erb Tobias J.)

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1.
  • Kehoe, Laura, et al. (author)
  • Make EU trade with Brazil sustainable
  • 2019
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Journal article (other academic/artistic)
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2.
  • Sendker, Franziska L., et al. (author)
  • Emergence of fractal geometries in the evolution of a metabolic enzyme
  • 2024
  • In: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 628:8009, s. 894-900
  • Journal article (peer-reviewed)abstract
    • Fractals are patterns that are self-similar across multiple length-scales1. Macroscopic fractals are common in nature2,3,4; however, so far, molecular assembly into fractals is restricted to synthetic systems5,6,7,8,9,10,11,12. Here we report the discovery of a natural protein, citrate synthase from the cyanobacterium Synechococcus elongatus, which self-assembles into Sierpiński triangles. Using cryo-electron microscopy, we reveal how the fractal assembles from a hexameric building block. Although different stimuli modulate the formation of fractal complexes and these complexes can regulate the enzymatic activity of citrate synthase in vitro, the fractal may not serve a physiological function in vivo. We use ancestral sequence reconstruction to retrace how the citrate synthase fractal evolved from non-fractal precursors, and the results suggest it may have emerged as a harmless evolutionary accident. Our findings expand the space of possible protein complexes and demonstrate that intricate and regulatable assemblies can evolve in a single substitution.
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Type of publication
journal article (2)
Type of content
other academic/artistic (1)
peer-reviewed (1)
Author/Editor
Rothhaupt, Karl-Otto (1)
Weigend, Maximilian (1)
Benesch, Justin L P (1)
Müller, Jörg (1)
Farrell, Katharine N ... (1)
Islar, Mine (1)
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Krause, Torsten (1)
Uddling, Johan, 1972 (1)
Alexanderson, Helena (1)
Schneider, Christoph (1)
Battiston, Roberto (1)
Lukic, Marko (1)
Pereira, Laura (1)
Riggi, Laura (1)
Cattaneo, Claudio (1)
Jung, Martin (1)
Andresen, Louise C. (1)
Kasimir, Åsa (1)
Wang-Erlandsson, Lan (1)
Sutherland, William ... (1)
Boonstra, Wiebren J. (1)
Vajda, Vivi (1)
Pascual, Unai (1)
Tscharntke, Teja (1)
Brown, Calum (1)
Peterson, Gustaf (1)
Meyer, Carsten (1)
Seppelt, Ralf (1)
Johansson, Maria (1)
Martin, Jean Louis (1)
Olsson, Urban (1)
Hortal, Joaquin (1)
Buckley, Yvonne (1)
Petrovan, Silviu (1)
Schindler, Stefan (1)
Carvalho, Joana (1)
Amo, Luisa (1)
Machordom, Annie (1)
De Smedt, Pallieter (1)
Lindkvist, Emilie (1)
Matos-Maraví, Pável (1)
Bacon, Christine D. (1)
Silvestro, Daniele (1)
Mascarenhas, André (1)
McPhearson, Timon (1)
Tengö, Maria (1)
Morales, Manuel B. (1)
Kanka, Robert (1)
Lehikoinen, Aleksi (1)
Guedes, Thais (1)
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University
Royal Institute of Technology (1)
Uppsala University (1)
Lund University (1)
Mid Sweden University (1)
Chalmers University of Technology (1)
Swedish University of Agricultural Sciences (1)
Language
English (2)
Research subject (UKÄ/SCB)
Natural sciences (2)
Engineering and Technology (1)
Social Sciences (1)

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