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Träfflista för sökning "WFRF:(Ernst Kati J.) "

Search: WFRF:(Ernst Kati J.)

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1.
  • Kehoe, Laura, et al. (author)
  • Make EU trade with Brazil sustainable
  • 2019
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Journal article (other academic/artistic)
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2.
  • Liu, Ilon, et al. (author)
  • The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
  • 2022
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 54:12, s. 1881-1894
  • Journal article (peer-reviewed)abstract
    • Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly recognized in adults. Their potential heterogeneity at different ages and midline locations is vastly understudied. Here, through dissecting the single-cell transcriptomic, epigenomic and spatial architectures of a comprehensive cohort of patient H3-K27M DMGs, we delineate how age and anatomical location shape glioma cell-intrinsic and -extrinsic features in light of the shared driver mutation. We show that stem-like oligodendroglial precursor-like cells, present across all clinico-anatomical groups, display varying levels of maturation dependent on location. We reveal a previously underappreciated relationship between mesenchymal cancer cell states and age, linked to age-dependent differences in the immune microenvironment. Further, we resolve the spatial organization of H3-K27M DMG cell populations and identify a mitotic oligodendroglial-lineage niche. Collectively, our study provides a powerful framework for rational modeling and therapeutic interventions.
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journal article (2)
Type of content
other academic/artistic (1)
peer-reviewed (1)
Author/Editor
Rothhaupt, Karl-Otto (1)
Weigend, Maximilian (1)
Müller, Jörg (1)
Farrell, Katharine N ... (1)
Islar, Mine (1)
Krause, Torsten (1)
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Uddling, Johan, 1972 (1)
Alexanderson, Helena (1)
Schneider, Christoph (1)
Battiston, Roberto (1)
Lukic, Marko (1)
Pereira, Laura (1)
Riggi, Laura (1)
Cattaneo, Claudio (1)
Jung, Martin (1)
Andresen, Louise C. (1)
Kasimir, Åsa (1)
Beck, Alexander (1)
Wang-Erlandsson, Lan (1)
Sutherland, William ... (1)
Boonstra, Wiebren J. (1)
Vajda, Vivi (1)
Pascual, Unai (1)
Tscharntke, Teja (1)
Brown, Calum (1)
Peterson, Gustaf (1)
Meyer, Carsten (1)
Seppelt, Ralf (1)
Jones, David T. W. (1)
Johansson, Maria (1)
Martin, Jean Louis (1)
Olsson, Urban (1)
Hortal, Joaquin (1)
Buckley, Yvonne (1)
Petrovan, Silviu (1)
Schindler, Stefan (1)
Carvalho, Joana (1)
Amo, Luisa (1)
Machordom, Annie (1)
De Smedt, Pallieter (1)
Lindkvist, Emilie (1)
Matos-Maraví, Pável (1)
Bacon, Christine D. (1)
Silvestro, Daniele (1)
Mascarenhas, André (1)
McPhearson, Timon (1)
Tengö, Maria (1)
Morales, Manuel B. (1)
Kanka, Robert (1)
Lehikoinen, Aleksi (1)
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University
Royal Institute of Technology (1)
Stockholm University (1)
Lund University (1)
Mid Sweden University (1)
Chalmers University of Technology (1)
Swedish University of Agricultural Sciences (1)
Language
English (2)
Research subject (UKÄ/SCB)
Natural sciences (1)
Engineering and Technology (1)
Medical and Health Sciences (1)
Social Sciences (1)

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