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Search: WFRF:(Evans WE)

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1.
  • Daly, AK, et al. (author)
  • Nomenclature for human CYP2D6 alleles
  • 1996
  • In: Pharmacogenetics. - : Ovid Technologies (Wolters Kluwer Health). - 0960-314X. ; 6:3, s. 193-201
  • Journal article (peer-reviewed)
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  • Eichelbaum, M, et al. (author)
  • Pharmacogenomics and individualized drug therapy
  • 2006
  • In: Annual review of medicine. - : Annual Reviews. - 0066-4219 .- 1545-326X. ; 57, s. 119-137
  • Journal article (peer-reviewed)abstract
    • Pharmacogenetics deals with inherited differences in the response to drugs. The best-recognized examples are genetic polymorphisms of drug-metabolizing enzymes, which affect about 30% of all drugs. Loss of function of thiopurine S-methyltransferase (TPMT) results in severe and life-threatening hematopoietic toxicity if patients receive standard doses of mercaptopurine and azathioprine. Gene duplication of cytochrome P4502D6 (CYP2D6), which metabolizes many antidepressants, has been identified as a mechanism of poor response in the treatment of depression. There is also a growing list of genetic polymorphisms in drug targets that have been shown to influence drug response. A major limitation that has heretofore moderated the use of pharmacogenetic testing in the clinical setting is the lack of prospective clinical trials demonstrating that such testing can improve the benefit/risk ratio of drug therapy.
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