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| 2. |
- Ekstrand, Carl, et al.
(author)
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Plasma Dexamethasone Concentration in Relation to Glucose Response in the Horse
- 2019
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In: Journal of Equine Veterinary Science. - : Elsevier BV. - 0737-0806 .- 1542-7412. ; 73, s. 75-80
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Journal article (peer-reviewed)abstract
- Therapeutic agents capable of altering the performance of horses are monitored in racing and equestrian sports to guarantee horse welfare, fair competition, and integrity of the sport. Dexamethasone is a common glucocorticoid drug for treating horses. Among other effects, dexamethasone is gluconeogenic and increases blood glucose. In this study, plasma samples from two dexamethasone exposure studies were analyzed for glucose using an automated clinical chemistry analyzer. In study one, dexamethasone-21-isonicotinate was administered to six horses at the dose 30 mu g/kg intramuscularly. In study two, dexamethasone 21-phosphate disodium salt was administered intravenously to six horses as a bolus dose followed by 3 hours of infusion (bolus + infusion) at four different doses (placebo, 0.1 + 0.07 mu g/kg, 1 + 0.7 mu g/kg, and 10 + 7 mu g/kg). Plasma dexamethasone concentrations were linked to plasma glucose concentrations by means of a turnover model. The median (range) pharmacodynamic parameters for glucose response for the two studies were as follows: the EC50 value was 0.84 mu g/L (0.47-1.50) and 0.85 mu g/L (0.75-2.45), the fractional turnover rate of response was 0.18 per h (0.07-0.27) and 0.25 per h (0.17-0.48), and the unaffected baseline of response was 4.20 mmol/L (4.10-6.60) and 5.42 mmol/L (5.22-5.96). These results may be used as input to future studies of the anti- inflammatory response of dexamethasone. The results also enable calculations of irrelevant plasma concentrations to determine whether the presence of a drug is a trace from legitimate medication or not. Therefore, this study provides further evidence for dexamethasone screening limits, which protects the integrity of the sport and the welfare of the horse. (C) 2018 Elsevier Inc. All rights reserved.
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| 3. |
- Falkenö, Ulrika, et al.
(author)
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Anemia in a dog
- 2013
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Other publication (other academic/artistic)
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| 4. |
- Falkenö, Ulrika, et al.
(author)
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Biological variation of 20 analytes measured in serum from clinically healthy domestic cats
- 2016
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In: Journal of Veterinary Diagnostic Investigation. - : SAGE Publications. - 1040-6387 .- 1943-4936. ; 28, s. 699-704
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Journal article (peer-reviewed)abstract
- The applications of data on biological variation include assessment of the utility of population-based reference intervals, evaluation of the significance of change in serial results, and setting of analytical quality specifications. We investigated the biological variation of 19 biochemistry analytes and total T4, measured in serum from 7 clinically healthy domestic cats sampled once weekly for 5 weeks. Samples were frozen and analyzed in random order in the same analytical run. Results were analyzed for outliers, and the components of variance, subsequently generated by restricted maximum likelihood, were used to determine within-subject and between-subject variation (CVI and CVG, respectively), as well as analytical variation (CVA) for each analyte. Indices of individuality, reference change values, and analytical performance goals were calculated. The smallest CVI and CVG were found for calcium, chloride, and sodium, whereas the largest values were calculated for bile acids. Nine analytes (albumin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, cholesterol, creatinine, phosphate [phosphorus], total protein, total T4) demonstrated high individuality, indicating limited utility of population-based reference intervals. Individuality was low, and population-based reference intervals were thereby considered appropriate for 5 analytes (bile acids, calcium, fructosamine, glucose, potassium). The intermediate individuality observed for 4 analytes (creatine kinase, iron, magnesium, urea) indicated that population-based reference intervals should be used with caution.
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| 5. |
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| 6. |
- Falkenö, Ulrika, et al.
(author)
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Theileria annae in a young Swedish dog
- 2013
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In: Acta Veterinaria Scandinavica. - : Springer Science and Business Media LLC. - 0044-605X .- 1751-0147. ; 55
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Journal article (peer-reviewed)abstract
- A severe regenerative anemia was detected in a 12-week-old mixed breed puppy in Sweden. A small protozoan parasite was observed in erythrocytes on a blood smear. It was initially suspected to be Babesia gibsoni based on its size and because B. gibsoni was previously recorded in Sweden. Surprisingly, specific polymerase chain reaction analysis identified the protozoan as Theileria annae. T. annae is endemic in Northwest Spain, is very uncommonly reported elsewhere and has never been recorded in Scandinavia. T. annae has been identified in dogs used for dog fighting, and it is thought to be transmitted by dog bites. This puppy was a mixed pit bull terrier. Pit bull terriers are sometimes used for dog fighting. T. annae has been reported to be transmitted vertically, and in light of the puppy's age, this transmission was suspected in the present case.
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| 7. |
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| 8. |
- Hernlund, Elin, et al.
(author)
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Theileria equi orsakade klinisk piroplasmos hos två importhästar.
- 2013
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In: Svensk Veterinärtidning. - 0346-2250. ; 65, s. 11-16
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Journal article (other academic/artistic)abstract
- Klinisk piroplasmos orsakad av Theileria equi upptäcktes hos två hästar som nyligen förts in i Sverige från Spanien. Sjukdomen är anmälningspliktig och förekommer normalt inte i Sverige eftersom de fästing - arter som fungerar som vektorer saknas här. Diagnosen komplicerades av att hästarna samtidigt var sjuka i akut hästinfluensa. Piroplasmos bör beaktas hos hästar med feber, anemi och ikterus, särskilt om de kommer från områden en - demiska för ekvin piroplasmos. Om nya fästingarter får fäste i Sverige kan infektionen komma att spridas från seropositiva hästar.
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| 9. |
- Strage, Emma, et al.
(author)
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Feline Heinz bodies interfering in standard bicarbonate analysis by the ABL90 FLEX
- 2023
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In: Veterinary Clinical Pathology. - 0275-6382 .- 1939-165X. ; 52, s. 548-553
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Journal article (peer-reviewed)abstract
- Venous blood gases were analyzed with ABL90 FLEX in two cats with Heinz bodies in approximately 60% of the erythrocytes. The instrument demonstrated an inability to correctly report standard bicarbonate (stHCO(3)(-)), hematocrits, and hemoglobin concentrations by indicating an OXI spectrum mismatch alarm (ie, the spectrum of measured hemoglobin forms differed from the spectrum of calculated forms). Actual bicarbonate (aHCO(3)(-)) did not indicate any errors. The ABL90 FLEX uses spectrophotometry to measure hemoglobin, and the presence of Heinz bodies interfered with the measurement in these cases. Because hemoglobin is included in the formula for calculating stHCO(3)(-), the instrument gave an alarm for stHCO(3)(-). At follow-up, Heinz bodies were present in only 2%-3% of the erythrocytes, and the ABL90 FLEX did not indicate any alarm messages. To the authors' knowledge, these are the first cases reported that have interference in stHCO(3)(-) measurements due to Heinz body formation using the ABL90 FLEX, a common blood gas instrument used in both veterinary and human critical care. The methodology used for evaluating acid-base status should be taken into consideration, and caution is needed when interpreting acid-base results in cats with Heinz bodies.
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