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1.	Farnebo, F, et al. (author) Allelic loss on chromosome 11 is uncommon in parathyroid glands of patients with hypercalcaemic secondary hyperparathyroidism 1997 In: The European journal of surgery = Acta chirurgica. - 1102-4151. ; 163:5, s. 331-337 Journal article (peer-reviewed)
2.	Farnebo, F, et al. (author) Alterations of the MEN1 gene in sporadic parathyroid tumors 1998 In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 83:8, s. 2627-2630 Journal article (peer-reviewed)
3.	Farnebo, F, et al. (author) Alternative genetic pathways in parathyroid tumorigenesis 1999 In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X. ; 84:10, s. 3775-3780 Journal article (peer-reviewed)
4.	Farnebo, F, et al. (author) Decreased expression of calcium-sensing receptor messenger ribonucleic acids in parathyroid adenomas 1998 In: Surgery. - : Elsevier BV. - 0039-6060. ; 124:6, s. 1094-1098 Journal article (peer-reviewed)
5.	Farnebo, F, et al. (author) Differential loss of heterozygosity in familial, sporadic, and uremic hyperparathyroidism 1997 In: Human genetics. - : Springer Science and Business Media LLC. - 0340-6717 .- 1432-1203. ; 99:3, s. 342-349 Journal article (peer-reviewed)
6.	Farnebo, F, et al. (author) Evaluation of retinoblastoma and Ki-67 immunostaining as diagnostic markers of benign and malignant parathyroid disease 1999 In: World journal of surgery. - : Springer Science and Business Media LLC. - 0364-2313 .- 1432-2323. ; 23, s. 68- Journal article (peer-reviewed)
7.	Farnebo, F, et al. (author) Expression of matrix metalloproteinase gelatinase A messenger ribonucleic acid in parathyroid carcinomas 1999 In: Surgery. - : Elsevier BV. - 0039-6060. ; 126, s. 1183- Journal article (peer-reviewed)
8.	Farnebo, F, et al. (author) Multiple endocrine neoplasia type 1 and the search for the genetic trigger 1997 In: Hormone research. - : S. Karger AG. - 0301-0163 .- 1423-0046. ; 47:4-6, s. 179-184 Journal article (peer-reviewed)
9.	Farnebo, F, et al. (author) Tumor-specific decreased expression of calcium sensing receptor messenger ribonucleic acid in sporadic primary hyperparathyroidism 1997 In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X. ; 82, s. 3481- Journal article (peer-reviewed)
10.	Forsberg, L, et al. (author) Homozygous inactivation of the MEN1 gene as a specific somatic event in a case of secondary hyperparathyroidism 2001 In: European journal of endocrinology. - : Oxford University Press (OUP). - 0804-4643 .- 1479-683X. ; 145:4, s. 415-420 Journal article (peer-reviewed)abstract BACKGROUND: Most patients who have been surgically treated for secondary hyperparathyroidism (HPT) harbor at least one pathological parathyroid gland with a tumor of monoclonal origin. OBJECTIVE: To elucidate the underlying genetic mechanisms behind secondary HPT, by studying a panel of such tumors for numerical alterations. METHODS: Sixteen parathyroid glands from eight patients (median age 58 years, range 31-74 years), were screened for numerical chromosomal imbalances, using comparative genomic hybridization (CGH). Mutation analysis of the multiple endocrine neoplasia type 1 gene (MEN1) was also performed by sequencing of the coding region. RESULTS: The results show that gross chromosomal alterations occur rarely in secondary HPT. In one of the three glands analyzed from one patient, a complete loss of chromosome 11 was detected. This gland also had an inactivating nonsense mutation, E469X, of the MEN1 gene. The mutation was present neither in the other two glands, nor in the constitutional tissue of the same patient, thus confirming its somatic origin. CONCLUSIONS: The relative lack of numerical chromosomal alterations would suggest that more discrete genetic alterations are responsible for the monoclonal growth in the majority of cases of secondary HPT. Furthermore, somatic inactivation of the MEN1 tumor suppressor gene contributes to the tumorigenesis in a small proportion of the cases.

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Result 1-10 of 52

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Type of publication: journal article (45); conference paper (7)

Type of content: peer-reviewed (43); other academic/artistic (9)

Author/Editor: Farnebo, LO (52); Larsson, C (35); Hoog, A (18); Farnebo, F (16); Sandelin, K (10); Teh, BT (10); show more...; Backdahl, M (9); Hamberger, B (9); Grimelius, L (8); Branstrom, R (7); Forsberg, L. (7); Valimaki, S (7); Lu, M (6); Kytola, S (6); Enberg, U (5); Kjellman, M (5); Nordenstrom, J (4); Wallin, G (4); Wedell, A (4); Svensson, A (4); THOREN, M (4); Thompson, NW (4); Zedenius, J (3); Jacobsson, H (3); Holst, M (3); Vukojevic, V (3); Lui, WO (3); Villablanca, A (3); Robinson, B. (3); Conigrave, AD (3); Wong, FK (3); Twigg, S (3); Obara, T (3); Weber, G. (2); Nilsson, O (2); Lundell, G (2); Auer, G (2); Korpi-Hyovalti, E (2); Kallioniemi, OP (2); Shabo, I (2); Mun, HC (2); Arnold, A (2); Carpten, JD (2); Volpe, C (2); Robbins, CM (2); Shoback, D (2); Wassif, WS (2); Clark, OH (2); Gaz, RD (2); Wierman, ME (2); show less...

University: Karolinska Institutet (50); Uppsala University (8); Lund University (1)

Language: English (52)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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