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- Spehar, Andrea, 1973
(author)
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Gender equality for whom? A critical frame analysis of the 2007 Swedish domestic services tax reform
- 2015
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In: Critical Social Policy. - : SAGE Publications. - 0261-0183 .- 1461-703X. ; 35:3, s. 350-368
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Journal article (peer-reviewed)abstract
- This article considers the motivations behind a 2007 reform in Sweden to implement a tax deduction on domestic services for households, and how the reform could be passed despite extensive political opposition to it. Critical framing analysis is used to argue that at least a partial explanation for the policy reform is to be found in the inherent limitations of the gender equality policy as hitherto pursued in the country, and in the way these limitations were framed in the political debates to push for the reform. The analysis draws upon public documents and records of parliamentary and media debates.
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- van de Beek, Jaap
(author)
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Synchronization and channel estimation in OFDM systems
- 1998
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Doctoral thesis (other academic/artistic)abstract
- This thesis addresses synchronization and channel estimation in OFDM communication systems. The joint maximum likliehood estimator of symbol time and carrier frequency offsets for OFDM systems using a cyclic prefix is presented. This estimator exploits the redundancy introduced by the prefix and does not require extra pilot information. Signal models, accounting for pulse shaping, channel dispersion, or slowly changing synchronization errors and the associated maximum likliehood estimators are presented. Tracking synchronization of a multiuser OFDM system, which often has been questioned, is feasible using a scheme incorporating the above estimator concept. Furthermore, this thesis analyzes channel estimators based on the discrete Fourier transform. The symbol error rate of systems employing these estimators may experience an irreducible error floor. A novel channel estimation concept using singular-value decomposition of the channel attenuations is presented. These channel estimators, designed with suitably chosen fixed design parameters, combine low-complexity and high performance.
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- Hehir, Michael K., et al.
(author)
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Myasthenia gravis patient and physician opinions about immunosuppressant reduction
- 2020
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In: Muscle and Nerve. - : Wiley. - 0148-639X .- 1097-4598. ; 61:6, s. 767-772
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Journal article (peer-reviewed)abstract
- IntroductionTo reduce myasthenia gravis (MG) patient risk of immunosuppressant (IS) exposure adverse events (AEs), such as infections and malignancies, and to reduce treatment burden, international guidelines recommend decreasing IS dose in stable MG patients.MethodsOnline surveys were conducted of self‐identified MG patients and MG physician experts about the importance of IS dose reduction for MG patients who achieve prolonged periods of disease stability.ResultsEighty‐four percent of MG patients (n = 283) and 100% of physicians (n = 45) were concerned about long‐term IS‐associated AEs. Although both groups favored attempting IS reduction, they raised concerns including MG relapse, hospitalization, and uncertainty about the future. Presented with an estimated 12% significant relapse rate with IS dose reduction, 76% of patients would be willing to enroll in a randomized IS dose reduction trial.DiscussionPatients and physicians favor considering IS dose reduction but are also concerned about potential negative sequelae.
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- Shulumba, Nina, et al.
(author)
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Intrinsic localized mode and low thermal conductivity of PbSe
- 2017
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In: PHYSICAL REVIEW B. - : AMER PHYSICAL SOC. - 2469-9950. ; 95:1
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Journal article (peer-reviewed)abstract
- Lead chalcogenides such as PbS, PbSe, and PbTe are of interest for their exceptional thermoelectric properties and strongly anharmonic lattice dynamics. Although PbTe has received the most attention, PbSe has a lower thermal conductivity and a nonlinear temperature dependence of thermal resistivity despite being stiffer, trends that prior first-principles calculations have not fully reproduced. Here, we use ab initio calculations that explicitly account for strong anharmonicity and a computationally efficient stochastic phase-space sampling scheme to identify the origin of this low thermal conductivity as an anomalously large anharmonic interaction, exceeding in strength that in PbTe, between the transverse optic and longitudinal acoustic branches. The strong anharmonicity is reflected in the striking observation of an intrinsic localized mode that forms in the acoustic frequencies. Our work shows the deep insights into thermal phonons that can be obtained from ab initio calculations that do not rely on perturbations from the ground-state phonon dispersion.
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- Turanli, Beste, et al.
(author)
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A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine
- 2018
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In: Current Pharmaceutical Design. - : Bentham Science Publishers Ltd.. - 1873-4286 .- 1381-6128. ; 24:32, s. 3778-3790
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Research review (peer-reviewed)abstract
- A complex framework of interacting partners including genetic, proteomic, and metabolic networks that cooperate to mediate specific functional phenotypes drives human biological processes. Recent technological and analytical advances in "omic" sciences allow the identification and elucidation of reprogramming biological functions in response to perturbations in cells and tissues. To understand such a complex system, biological networks are generated to reduce the complexity into relatively simple models, and the integration of these molecular networks from different perspectives is implemented for a holistic interpretation of the entire system. Ultimately, network-based methods will effectively facilitate the development and improvement of precision medicine by directing therapies based on the underlying biology of a given patient's disease. The goal of precision medicine is to identify novel therapeutic strategies that can be optimized for each disease type or each patient based on the underlying genetic, environmental, and lifestyle factors. Pharmaco-omics analyses based on an integration of pharmacology and various "omics" data types can be employed to develop effective treatment strategies using particular drugs and doses that are tailored to each individual. In the current review, we first present the core elements of network-based systems biology in the context of pharmaco-omics followed by integration of multi-omics data using various biological networks. Next, we provide an opening into precise medicine and drug targeting based on network approaches. Lastly, we review the current significant efforts as well as the accomplishments and limitations in precise drug targeting with the utility of network-based guided drug discovery methods for effective treatment of breast cancer.
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- Langmann, Edwin
(author)
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Second quantization of the elliptic Calogero-Sutherland model
- 2004
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In: Communications in Mathematical Physics. - : Springer Science and Business Media LLC. - 0010-3616 .- 1432-0916. ; 247:2, s. 321-351
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Journal article (peer-reviewed)abstract
- We construct a quantum field theory model of anyons on a circle and at finite temperature. We find an anyon Hamiltonian providing a second quantization of the elliptic Calogero-Sutherland model. This allows us to prove a remarkable identity which is a starting point for an algorithm to construct eigenfunctions and eigenvalues of the elliptic Calogero-Sutherland Hamiltonian.
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- Smith, Göran, 1988, et al.
(author)
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Towards a Framework for Mobility-as-a-Service Policies
- 2019
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Conference paper (other academic/artistic)abstract
- Public authorities are increasingly pursuing activities to pave the way for Mobility-as-a-Service (MaaS). The range of activities includes regulation reforms, technology developments and investments in trials. Despite progress, concrete MaaS developments are still limited. Thus, it remains uncertain how effective the current MaaS policies will be in terms of facilitating the development and diffusion of MaaS that generate public value. Drawing on collaborative innovation and sustainability transition literature, this paper aims to provide a basis for analyzing MaaS policies by introducing a framework that identifies aspects that such policies should address. An empirical analysis of Transport for New South Wales’s MaaS policy program is utilized to illustrate how the framework can be applied. The contribution to the transport literature is twofold. First, the paper refines the conceptual understanding of what MaaS is, and why it differs from the present state of affairs. Second, it advances the knowledge of how the public sector can facilitate its development and diffusion.
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