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1.	JAKOBSSON, PJ, et al. (author) The 5-lipoxygenase pathway in normal and malignant human B lymphocytes 1995 In: Advances in prostaglandin, thromboxane, and leukotriene research. - 0732-8141. ; 23, s. 293-298 Journal article (peer-reviewed)
2.	Vanags, DM, et al. (author) Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells 1997 In: Cell death and differentiation. - : Springer Science and Business Media LLC. - 1350-9047 .- 1476-5403. ; 4:6, s. 479-486 Journal article (peer-reviewed)
3.	Claesson, HE, et al. (author) Expression of enzymes involved in the synthesis of prostaglandins and leukotrienes in peripheral blood stem cells and in blasts of patients with acute myeloid leukemia (AML) 1996 In: BLOOD. - 0006-4971. ; 88:10, s. 2254-2254 Conference paper (other academic/artistic)
4.	Claesson, HE, et al. (author) Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma 2008 In: The FEBS journal. - : Wiley. - 1742-464X. ; 275:16, s. 4222-4234 Journal article (peer-reviewed)
5.	Claesson, HE, et al. (author) Leukotriene B4 plays a pivotal role in CD40 dependent activation of chronic B lymphocytic leukemia cells. 2004 In: BLOOD. - 0006-4971. ; 104:11, s. 285B-285B Conference paper (other academic/artistic)
6.	FELTENMARK, S, et al. (author) Diverse expression of cytosolic phospholipase A2, 5-lipoxygenase and prostaglandin H synthase 2 in acute pre-B-lymphocytic leukaemia cells 1995 In: British journal of haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 90:3, s. 585-594 Journal article (peer-reviewed)
7.	JAKOBSSON, PJ, et al. (author) Studies on the regulation and localization of 5-lipoxygenase in human B-lymphocytes 1995 In: European journal of biochemistry. - : Wiley. - 0014-2956 .- 1432-1033. ; 232:1, s. 37-46 Journal article (peer-reviewed)
8.	Runarsson, G, et al. (author) Expression of enzymes involved in the synthesis of prostaglandins and leukotrienes in peripheral blood stem cells and in blasts of patients with acute myeloid leukemia 1996 In: BRITISH JOURNAL OF HAEMATOLOGY. - 0007-1048. ; 93, s. 163-163 Conference paper (other academic/artistic)
9.	Runarsson, G, et al. (author) Leukotriene B-4 plays a pivotal role in CD40-dependent activation of chronic B lymphocytic leukemia cells 2005 In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 105:3, s. 1274-1279 Journal article (peer-reviewed)abstract Blosynthesis of leukotrienes (LTs) occurs in human myeloid cells and B lymphocytes. However, the function of leukotrienes in B lymphocytes is unclear. Here, we report that B-cell chronic lymphocytic leukemia (B-CLL) cells produce leukotriene B-4, and that specific leukotriene biosynthesis inhibitors counteracted CD40-dependent activation of B-CLL cells. Studies on the expression of the high-affinity receptor for LTB4 (BLT1) by flow cytometry analysis showed that the receptor was expressed, to a varying degree, in all investigated B-CLL clones. At a concentration of 100 nM, the drugs BWA4C (a specific 5-lipoxygenase inhibitor) and MK-886 (a specific 5-lipoxygenase activating protein inhibitor) markedly inhibited CD40-induced DNA synthesis (45% and 38%, respectively) and CD40-induced expression of CD23, CD54, and CD150. Addition of exogenous LTB4 (150 nM) almost completely reversed the effect of the inhibitors on DNA synthesis and antigen expression. Taken together, the results of the present study suggest that leukotriene biosynthesis inhibitors may have a therapeutic role in B-CLL.
10.	Runarsson, G, et al. (author) The expression of cytosolic phospholipase A2 and biosynthesis of leukotriene B4 in acute myeloid leukemia cells 2007 In: European journal of haematology. - : Wiley. - 1600-0609 .- 0902-4441. ; 79:6, s. 468-476 Journal article (peer-reviewed)

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Type of publication: journal article (7); conference paper (3)

Type of content: peer-reviewed (7); other academic/artistic (3)

Author/Editor: Claesson, HE (10); Feltenmark, S (10); Bjorkholm, M (8); Runarsson, G (7); Larsson, P (6); Jakobsson, PJ (4); show more...; Sjoberg, J (2); Klein, E (2); AguilarSantelises, M (2); Liu, AQ (2); Odlander, B (2); Mahshid, Y (2); Andersson, E (1); Paoletti, R. (1); Biberfeld, P (1); Jondal, M (1); Griffiths, WJ (1); Pettersson, Annika (1); Schain, F (1); Orrenius, S (1); Samuelsson, B (1); Ramwell, PW (1); Folco, G (1); Granstrom, E (1); Nicosia, S (1); Forsell, PKA (1); Porwit, A (1); Brunnstrorm, A (1); Johnson, HA (1); Vanags, DM (1); SHASKIN, P (1); show less...

University: Karolinska Institutet (10); Lund University (1)

Language: English (10)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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