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- Düzel, E., et al.
(författare)
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European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)
- 2019
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Ingår i: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. - : Wiley. - 2352-8729. ; 11, s. 538-549
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists. Methods: EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization. Results: The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh-field MRI studies and clinical trials. Discussion: The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use-cases for clinical applications in neurodegeneration. © 2018 The Authors
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- Melin, Jeanette, et al.
(författare)
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Metrological references for person ability in memory tests
- 2021
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Ingår i: Measurement: Sensors. - : Elsevier Ltd. - 2665-9174. ; 18
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Tidskriftsartikel (refereegranskat)abstract
- To ensure reliable diagnosis and treatment consistently throughout healthcare, metrological quality assurance is essential. There are, however, many observations in the social sciences and healthcare, such as the memory tests studied here, which have been ‘claimed’ to be measurements but in fact have not been fully metrologically legitimated. We have already argued in favour of extending traditional metrological underlying principles to cover social measurements, including the development of construct specification equations (CSE) considered as ‘recipes for certified reference materials (CRM)’ for traceability, analogous to CRMs in metrology in chemistry. Although the CSE approach has to date been used mostly to explain and validate test item attributes, this paper turns to focus on causal explanations of person characteristics. We describe methods and preliminary results developed in the European EMPIR NeuroMET projects, which may be used for providing quality assured measurement of disease progression and treatment benefits for patients with neurodegenerative conditions.
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