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- Bussy, Aurélie, et al.
(author)
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Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia
- 2023
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In: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 44:7, s. 2684-2700
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Journal article (peer-reviewed)abstract
- Recent studies have reported early cerebellar and subcortical impact in the disease progression of genetic frontotemporal dementia (FTD) due to microtubule-associated protein tau (MAPT), progranulin (GRN) and chromosome 9 open reading frame 72 (C9orf72). However, the cerebello-subcortical circuitry in FTD has been understudied despite its essential role in cognition and behaviors related to FTD symptomatology. The present study aims to investigate the association between cerebellar and subcortical atrophy, and neuropsychiatric symptoms across genetic mutations. Our study included 983 participants from the Genetic Frontotemporal dementia Initiative including mutation carriers and noncarrier first-degree relatives of known symptomatic carriers. Voxel-wise analysis of the thalamus, striatum, globus pallidus, amygdala, and the cerebellum was performed, and partial least squares analyses (PLS) were used to link morphometry and behavior. In presymptomatic C9orf72 expansion carriers, thalamic atrophy was found compared to noncarriers, suggesting the importance of this structure in FTD prodromes. PLS analyses demonstrated that the cerebello-subcortical circuitry is related to neuropsychiatric symptoms, with significant overlap in brain/behavior patterns, but also specificity for each genetic mutation group. The largest differences were in the cerebellar atrophy (larger extent in C9orf72 expansion group) and more prominent amygdalar volume reduction in the MAPT group. Brain scores in the C9orf72 expansion carriers and MAPT carriers demonstrated covariation patterns concordant with atrophy patterns detectable up to 20 years before expected symptom onset. Overall, these results demonstrated the important role of the subcortical structures in genetic FTD symptom expression, particularly the cerebellum in C9orf72 and the amygdala in MAPT carriers.
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| 3. |
- de Jong, Roelof S., et al.
(author)
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4MOST-4-metre Multi-Object Spectroscopic Telescope
- 2014
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In: Ground-based and Airborne Instrumentation for Astronomy V. - : SPIE. - 0277-786X .- 1996-756X. ; 9147
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Conference paper (peer-reviewed)abstract
- 4MOST is a wide-field, high-multiplex spectroscopic survey facility under development for the VISTA telescope of the European Southern Observatory (ESO). Its main science drivers are in the fields of galactic archeology, high-energy physics, galaxy evolution and cosmology. 4MOST will in particular provide the spectroscopic complements to the large area surveys coming from space missions like Gaia, eROSITA, Euclid, and PLATO and from ground-based facilities like VISTA, VST, DES, LSST and SKA. The 4MOST baseline concept features a 2.5 degree diameter field-of-view with similar to 2400 fibres in the focal surface that are configured by a fibre positioner based on the tilting spine principle. The fibres feed two types of spectrographs; similar to 1600 fibres go to two spectrographs with resolution R> 5000 (lambda similar to 390-930 nm) and similar to 800 fibres to a spectrograph with R> 18,000 (lambda similar to 392-437 nm & 515-572 nm & 605-675 nm). Both types of spectrographs are fixed-configuration, three-channel spectrographs. 4MOST will have an unique operations concept in which 5 year public surveys from both the consortium and the ESO community will be combined and observed in parallel during each exposure, resulting in more than 25 million spectra of targets spread over a large fraction of the southern sky. The 4MOST Facility Simulator (4FS) was developed to demonstrate the feasibility of this observing concept. 4MOST has been accepted for implementation by ESO with operations expected to start by the end of 2020. This paper provides a top-level overview of the 4MOST facility, while other papers in these proceedings provide more detailed descriptions of the instrument concept[1], the instrument requirements development[2], the systems engineering implementation[3], the instrument model[4], the fibre positioner concepts[5], the fibre feed[6], and the spectrographs[7].
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| 4. |
- Finger, David, et al.
(author)
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The value of multiple data set calibration versus model complexity for improving the performance of hydrological models in mountain catchments
- 2015
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In: Water resources research. - 0043-1397 .- 1944-7973. ; 51:4, s. 1939-1958
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Journal article (peer-reviewed)abstract
- The assessment of snow, glacier, and rainfall runoff contribution to discharge in mountain streams is of major importance for an adequate water resource management. Such contributions can be estimated via hydrological models, provided that the modeling adequately accounts for snow and glacier melt, as well as rainfall runoff. We present a multiple data set calibration approach to estimate runoff composition using hydrological models with three levels of complexity. For this purpose, the code of the conceptual runoff model HBV-light was enhanced to allow calibration and validation of simulations against glacier mass balances, satellite-derived snow cover area and measured discharge. Three levels of complexity of the model were applied to glacierized catchments in Switzerland, ranging from 39 to 103 km(2). The results indicate that all three observational data sets are reproduced adequately by the model, allowing an accurate estimation of the runoff composition in the three mountain streams. However, calibration against only runoff leads to unrealistic snow and glacier melt rates. Based on these results, we recommend using all three observational data sets in order to constrain model parameters and compute snow, glacier, and rain contributions. Finally, based on the comparison of model performance of different complexities, we postulate that the availability and use of different data sets to calibrate hydrological models might be more important than model complexity to achieve realistic estimations of runoff composition.
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| 5. |
- Haynes, Roger, et al.
(author)
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The 4MOST instrument concept overview
- 2014
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In: Ground-based and Airborne Instrumentation for Astronomy V. - : SPIE. - 0277-786X .- 1996-756X. ; 9147, s. 91476-91476
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Conference paper (peer-reviewed)abstract
- The 4MOST([1]) instrument is a concept for a wide-field, fibre-fed high multiplex spectroscopic instrument facility on the ESO VISTA telescope designed to perform a massive (initially >25x10(6) spectra in 5 years) combined all-sky public survey. The main science drivers are: Gaia follow up of chemo-dynamical structure of the Milky Way, stellar radial velocities, parameters and abundances, chemical tagging; eROSITA follow up of cosmology with x-ray clusters of galaxies, X-ray AGN/galaxy evolution to z similar to 5, Galactic X-ray sources and resolving the Galactic edge; Euclid/LSST/SKA and other survey follow up of Dark Energy, Galaxy evolution and transients. The surveys will be undertaken simultaneously requiring: highly advanced targeting and scheduling software, also comprehensive data reduction and analysis tools to produce high-level data products. The instrument will allow simultaneous observations of similar to 1600 targets at R similar to 5,000 from 390-900nm and similar to 800 targets at R>18,000 in three channels between similar to 395-675nm (channel bandwidth: 45nm blue, 57nm green and 69nm red) over a hexagonal field of view of similar to 4.1 degrees2. The initial 5-year 4MOST survey is currently expect to start in 2020. We provide and overview of the 4MOST systems: opto-mechanical, control, data management and operations concepts; and initial performance estimates.
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| 6. |
- Kjellén, Marianne, 1964-
(author)
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From Public Pipes to Private Hands : Water Access and Distribution in Dar es Salaam, Tanzania
- 2006
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Doctoral thesis (other academic/artistic)abstract
- In cities around the world, public water systems have increasingly come to be operated by private companies. Along with an internationally funded investment program to refurbish the dilapidated water infrastructure, private operations were tested also in Dar es Salaam, Tanzania. Only about a third of the households, however, are reached by the piped water system there; most households purchase water from those with pipe-connections or private boreholes. Thus, water distribution was informally privatized by way of water vending long before formal private sector participation began. This thesis explores individual and collective endeavors in water development, distribution, and access, along with the global and local influences that shaped the privatization exercise. With regard to the lease of Dar es Salaam’s water system, the institutional set-up has been found to mix the British and French models, having influenced the local situation through development assistance and conditionalities tied to loans. The institutional contradictions may have contributed to the conflictive cancellation of the lease arrangement. Due to the public utility company’s lack of operating capital and investment planning, infrastructure development has responded mainly to immediate individual demands, resulting in a spaghetti-like network and structural leakage. The long-standing under-performance and low coverage of the piped water system have forced many people to devise their own ways to access water. This thesis argues that the individually-devised artisan ways of water provisioning constitute the life-line of Dar es Salaam’s water system. Yet, they also undermine and divert resources away from the collectively-devised industrial form of piped water provision.
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| 7. |
- Smith, Göran, et al.
(author)
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Governing Mobility-as-a-Service : Insights from Sweden and Finland: Towards New Organizational Structures for the Development of Shared, Automated, Electric and Integrated Mobility
- 2019
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In: The Governance of Smart Transportation Systems : Towards new organizational structures for the development of shared, automated, electric and integrated mobility - Towards new organizational structures for the development of shared, automated, electric and integrated mobility. - 2365-757X. - 9783319965253 - 9783030072087 - 9783319965260 ; , s. 169-188
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Book chapter (peer-reviewed)abstract
- Based on a review of recent developments in Sweden and Finland, this chapter analyzes the roles of public organizations in the governance of a transition to Mobility-as-a-Service (MaaS). In particular, we draw on insights from transition frameworks to explore what these two pioneering cases can teach us about how the public sector can both enable the development of MaaS and steer the development trajectory toward diffusion of MaaS offerings that contribute to transport policy goals. We propose three main points. Firstly, public sector organizations at national, regional, and local levels have key roles to play in potential transitions to MaaS, regardless of their intended operative roles in the emerging MaaS ecosystem. Secondly, a central task for public sector organizations is to align operational and tactical MaaS governance activities with both an overarching MaaS strategy and with other relevant strategies, such as transport infrastructures investments, programs for economic and industrial growth, city plans, and parking norms. Thirdly, new models and tools for public–private collaboration are needed in order to effectively govern the development and diffusion of sustainable MaaS.
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