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1.	Schilling, KG, et al. (author) Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset? 2021 In: NeuroImage. - : Elsevier BV. - 1095-9572 .- 1053-8119. ; 243, s. 118502- Journal article (peer-reviewed)
2.	Fischi-Gomez, E., et al. (author) Ultrahigh field in vivo characterization of microstructural abnormalities in the orbitofrontal cortex and amygdala in autism 2021 In: European Journal of Neuroscience. - : Wiley. - 0953-816X .- 1460-9568. ; 54:6, s. 6229-6236 Journal article (peer-reviewed)abstract There are currently no biomarkers for autism spectrum disorder (ASD). This neurodevelopmental condition has previously been associated with histopathological findings, including increased neuronal packing density in the amygdala, abnormal laminar cytoarchitecture and increased average neuronal density in the prefrontal cortex. The present study examined whether new brain imaging technologies could reveal in vivo, in adults with ASD, the manifestation of previously described histopathological changes. Using quantitative mapping at ultrahigh field (7 Tesla), we show that we can observe microstructural alterations in the right lateral orbitofrontal cortex and the bilateral amygdala in adult individuals with ASD in vivo. These imaging alterations point to an abnormal laminar cytoarchitecture and to an increased neuronal density, similar to what has been previously described in post-mortem data in ASD. Our data demonstrate that it is possible to visualize, in vivo and at the individual level, alterations of cortical and subcortical microstructure in ASD. Future studies will be needed to extend these findings to a larger group of individuals and evaluate their association with symptomatology as well as their specificity among the different neurodevelopmental disorders.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Granziera, C (2); Zhang, F. (1); Bullock, D (1); Lebel, C. (1); Grenier, G. (1); Raja, R. (1); show more...; Joseph, M (1); Chen, J. (1); de Luca, A. (1); Abe, M (1); Parker, D (1); Sacco, S. (1); Saito, Y. (1); Savini, G. (1); Mancini, M. (1); Calhoun, VD (1); Toga, AW (1); Paulson, A (1); Yu, T (1); Shi, YG (1); Hadjikhani, Nouchine ... (1); Mancini, L. (1); Tang, W. (1); Ward, N (1); Barakovic, M (1); Girard, G (1); Schiavi, S (1); Descoteaux, M (1); Thiran, JP (1); Daducci, A (1); Houenou, J. (1); Voineskos, AN (1); Heuer, K (1); Zhan, Y (1); Leemans, A (1); Emsell, L. (1); Nakua, H (1); Canales-Rodriguez, E ... (1); Pizzolato, M (1); Legarreta, JH (1); Rafael-Patino, J (1); Mangin, JF (1); Cocozza, S. (1); Pontillo, G. (1); Vazquez, A (1); Sunaert, S (1); Duncan, JS (1); Welton, T (1); Nath, V. (1); Ramirez-Manzanares, ... (1); show less...

University: University of Gothenburg (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2021 (2)

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