| 1. |
- Bou Serhal, C, et al.
(author)
-
Perioperative validation of localisation of the mental foramen
- 2002
-
In: Dento-Maxillo-Facial Radiology. - : British institute of radiology. - 0250-832X .- 1476-542X. ; 31:1, s. 39-43
-
Journal article (peer-reviewed)abstract
- AIM: To assess the accuracy of panoramic radiography and spiral or computed tomography for the localisation of the mental foramen.MATERIALS AND METHODS: The distance from the alveolar crest to the mental foramen was measured from panoramic radiographs, spiral tomograms and CT scans. The same distance was measured during implant surgery using a specially designed caliper.RESULTS: Panoramic radiography showed more deviation (+0.6 mm) from the perioperative measurements than either spiral or computed tomography (+0.4 and -0.3 mm respectively). The difference was significant (P<0.05). In general, distances were overestimated on the panoramic radiographs.CONCLUSIONS: Cross-sectional imaging techniques are recommended for the pre-operative planning of implants in the posterior mandible.
|
|
| 2. |
- Eckerbom, M, et al.
(author)
-
A 20-year follow-up study of endodontic variables and apical status in a Swedish population
- 2007
-
In: International Endodontic Journal. - : Wiley-Blackwell. - 0143-2885 .- 1365-2591. ; 40:12, s. 940-948
-
Journal article (peer-reviewed)abstract
- AIM: To re-examine a population after 20 years and evaluate changes in prevalence of endodontic treatment and apical periodontitis, as well as the technical quality of root fillings.METHODOLOGY: One hundred and fifteen out of an original 200 patients living in the northern part of Sweden were re-examined with a full mouth radiographic survey after 20 years. Frequencies of root canal treated teeth, apical periodontitis and quality parameters of root fillings were registered.RESULTS: The frequency of root canal treated teeth increased significantly (P < 0.05) from 13.9% at the first investigation to 17.7% after 20 years. There was also a statistically significant increase (P < 0.05) in teeth with apical periodontitis from 3.3% to 6.8%. Apical periodontitis both in connection with root canal treated teeth and teeth without endodontic treatment, had increased during the follow-up period. Even though the quality of the root fillings had improved, there was no corresponding improvement of the apical status in teeth with root fillings.CONCLUSIONS: There is still a great need for endodontic treatment in the Swedish population, and no improvement in apical health was found during this 20-year follow up.
|
|
| 3. |
- Flygare, Lennart, et al.
(author)
-
Bone histomorphometry using interactive image analysis. A methodological study with application on the human temporomandibular joint.
- 1997
-
In: European Journal of Oral Sciences. - : Wiley-Blackwell. - 0909-8836 .- 1600-0722. ; 105:1, s. 67-73
-
Journal article (peer-reviewed)abstract
- The aim was to develop a reproducible method for bone histomorphometry with the aid of a computerized image analysis program, and to examine the variation when assessing the total and the trabecular bone volume. Histologic sections of 18 temporomandibular joint autopsy specimens were read interactively using a cursor. The two parameters total bone volume and trabecular bone volume, of the condyle and the temporal component respectively, were estimated 2 x by 1 observer using 3 different threshold settings: an automatic, a semi-automatic and a manual technique. The threshold was based on the gray-scale distribution of the image. 2 observers read the same sections with the aid of the semi-automatic technique. The intra-observer variation expressed as coefficient of variation ranged between 1.9% and 7.1% for the different parameters, when the automatic threshold setting technique was employed, and between 2.8% and 8.7% with the semi-automatic technique. The manual technique resulted in a high intra-observer variation with a coefficient of variation between 5.2% and 19.9%. There was a systematic difference between the estimates of the 2 observers. In general, intra- and inter-observer variation was higher in the temporal component than in the condyle. The inter-section variation was moderate, the coefficient of variation ranging from 3.8% to 11.1%. The automatic and semi-automatic techniques resulted in comparable intra-observer variation, with a lower bias in the estimates of the semi-automatic technique. By letting one observer apply the semi-automatic technique, it was possible to achieve fast and reproducible analysis of the total and trabecular bone volume.
|
|
| 4. |
- Flygare, Lennart, et al.
(author)
-
Bone volume in human temporomandibular autopsy joints with and without erosive changes
- 1997
-
In: Acta Odontologica Scandinavica. - : Informa Healthcare. - 0001-6357 .- 1502-3850. ; 55:3, s. 167-172
-
Journal article (peer-reviewed)abstract
- The aim was to compare the trabecular bone volume (TBV) and the total bone volume (TOBV) of human temporomandibular joints (TMJ) with erosive changes with those of joints without erosive changes. We examined 35 TMJ autopsy specimens from 19 individuals aged 66 88 years. Sagittal sections of the joints were analyzed microscopically for erosive hard-tissue changes. The TBV and the TOBV of the sections were assessed with the aid of computerized image analysis. A significant increase in trabecular and total bone volume was found in condyles with erosive changes (TBV = 21%, TOBV = 54%) as compared with condyles without erosive changes (TBV = 15%, TOBV = 40%). The trabecular bone volume of the temporal component was also increased (TBV = 24%) in joints with erosive changes in the condyle as compared with joints with unaffected condyles (TBV = 16%). The findings indicate that the relative bone mass may play a role in the development of erosive changes in the TMJ.
|
|
| 5. |
- Flygare, Lennart, et al.
(author)
-
Calcified cartilage zone and its dimensional relationship to the articular cartilage in the human temporomandibular joint of elderly individuals
- 1993
-
In: Acta Odontologica Scandinavica. - : Informa Healthcare. - 0001-6357 .- 1502-3850. ; 51:3, s. 183-191
-
Journal article (peer-reviewed)abstract
- The aim was to describe the appearance of the calcified cartilage zone (CCZ) and to determine its dimensional relationship to the articular cartilage thickness in the normal human temporomandibular joint. An autopsy material comprising 21 joints from 12 elderly individuals was examined microscopically. The appearance of the CCZ was examined, and the thickness of the CCZ and of the total articular cartilage was measured in 18 different positions in each joint. The CCZ was outlined by a flat or gently undulating tidemark and an irregular osteochondral junction. The cellularity of the CCZ varied extensively. The cells were numerous in the CCZ when the overlying articular cartilage displayed high cellularity. Statistical analysis of the measurements demonstrated a relationship (p < 0.001) between the thickness of the CCZ and of the articular cartilage. Our findings, both qualitative and quantitative, indicate a close relationship between the physiology of the CCZ and of the overlying articular cartilage.
|
|
| 6. |
- Flygare, Lennart, et al.
(author)
-
Cartilage matrix macromolecules in lavage fluid of temporomandibular joints before and 6 months after diskectomy
- 1997
-
In: European Journal of Oral Sciences. - : Wiley-Blackwell. - 0909-8836 .- 1600-0722. ; 105:4, s. 369-372
-
Journal article (peer-reviewed)abstract
- The purpose was to investigate if antigenic fragments of aggrecan and cartilage oligomeric matrix protein (COMP) are detectable by enzyme-linked immunosorbent assay in lavage fluids from the temporomandibular joint (TMJ) and to examine if the relative content of these cartilage markers changes during development of osteoarthrosis (OA) after diskectomy. Lavage fluid was obtained at surgery and 6 months postoperatively in 13 patients. Computed tomography or magnetic resonance imaging was without evidence of hard-tissue changes prior to surgery in all patients. In 9 of the patients, sufficient material for analysis was obtained at both examinations. Aggrecan and COMP were detectable in all but 2 fluids, in which the COMP levels were below detection limit. The aggrecan/COMP ratio increased in all 9 patients during the 6-month period, indicating increased release of aggrecan relative to COMP fragments. The changed aggrecan/COMP ratio possibly reflects increased cartilage turnover during development of OA. Changes compatible with OA were present on computed tomography in all cases at the 6-month follow-up. This study shows that the lavage procedure is feasible for obtaining synovial fluid from the TMJ for immunochemical analyses of tissue-derived macromolecules.
|
|
| 7. |
- Flygare, Lennart, et al.
(author)
-
Chronic recurrent multifocal osteomyelitis involving both jaws : report of a case including magnetic resonance correlation
- 1997
-
In: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. - : Elsevier. - 1079-2104 .- 1528-395X. ; 83:2, s. 300-305
-
Journal article (peer-reviewed)abstract
- A case of chronic recurrent multifocal osteomyelitis in a 14-year-old girl is presented. The disease had an initial aggressive osteolytic appearance involving both the maxilla and the mandible. Conservative treatment with minimal surgical intervention has been successful in this case during a 2-year follow-up period. The value of magnetic resonance imaging and bone scintigraphy in this case and the cause of chronic recurrent multifocal osteomyelitis is discussed.
|
|
| 8. |
- Flygare, Lennart, 1961-
(author)
-
Degenerative changes of the human temporomandibular joint : A radiological, microscopical, histomorphometrical and biochemical study
- 1997
-
Doctoral thesis (other academic/artistic)abstract
- In five autopsy specimen studies human temporomandibular joints were investigated by conventional tomography, macroscopy, and microscopy for degenerative changes, in particular erosive hard-tissue changes.In the microscopical evaluation special attention was paid to the calcified cartilage. The calcified cartilage was outlined by a flat or gently undulating basophilic tidemark and an irregular osteochondral junction. A significant correlation was found between the thickness of the calcified cartilage and that of the total articular cartilage. Two types of erosive changes were found; an extensive type with complete loss of overlying cartilage and a local type with retained cartilage. The erosive changes were generally more extensive in the condyle. Microscopically, the erosive changes in the condyle were evenly distributed. In the temporal component there was a slight predominance of these changes located to the lateral part of the tubercle. Tomography underestimated both the presence and the extent of the erosive changes. Positive predictive values and negative predictive values were 0.70 and 0.83, respectively, for changes in the condyle and 0.91 and 0.68 for changes in the temporal component. The likelihood ratio for a positive test was 10.6 in the temporal component and 5.6 in the condyle. The likelihood ratio for a negative test was comparable in the two joint components 0.49 and 0.47 respectively. Three different techniques of computer-aided bone histomorphometry (manual, automatic and semi-automatic) were assessed. The variation when assessing the total and trabecular bone volume was evaluated. Good reproducibility in the assessment of the total and trabecular bone volume was achieved with the aid of a single observer and a semi-automatic technique. This technique was therefore used to assess the total and trabecular bone volume in condyles and temporal components of joints with and without microscopically verified erosive changes. Condyles with erosive changes demonstrated both a higher trabecular bone volume (P< 0.05) and higher total bone volume (P< 0.01) than condyles without erosive changes. In a clinical study on patients undergoing diskectomy, the two cartilage matrix macromolecules aggrecan and cartilage oligomeric matrix protein (COMP) were quantified by enzyme-linked immunosorbent assay in lavage fluids from temporomandibular joints before and six months after surgery. The aggrecan/COMP ratio was higher in the lavage fluid of all joints at follow-up as compared to preoperatively. All joints developed radiographic changes indicative of degenerative changes (osteoarthrosis) during the postoperative period.
|
|
| 9. |
- Flygare, Lennart, 1961-, et al.
(author)
-
Distant metastases and synchronous malignancies on FDG-PET/CT in patients with head and neck cancer : a retrospective study
- 2020
-
In: Acta Radiologica. - : Sage Publications. - 0284-1851 .- 1600-0455. ; 61:9, s. 1196-1204
-
Journal article (peer-reviewed)abstract
- Background: Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has been proven to be a good method to detect distant spread of head and neck cancer (HNC). However, most prior studies are based on Asian populations and may not be directly transferable to western populations.Purpose: To investigate the frequency and distribution of distant metastases and synchronous malignancies detected by PET/CT in HNC in a northern Swedish population.Material and Methods: All primary whole-body FDG-PET/CT examinations performed on the suspicion of HNC (n = 524 patients) between 1 January 2013 and 31 December 2016 at Umeå University Hospital in Sweden were retrospectively reviewed . After the exclusion of 189 examinations without evidence of primary HNC, 335 examinations were analyzed.Results: Distant metastases were detected in 10 (3%) patients, all with advanced primary tumors corresponding to TNM stage 3–4, most frequently in salivary gland adenocarcinoma, where 50% of patients had distant spread. Four patients had metastases below the diaphragm, representing 20% of the salivary gland malignancies. In the remaining six patients, metastases were supraphrenic, of which all but one were identified by CT alone. Synchronous malignancies were discovered in 14 (4.2%) patients, of which five were below the diaphragm.Conclusion: The overall frequency of distant spread and synchronous malignancy in primary HNC was generally low. However, the risk for distant metastases below the diaphragm was relatively higher in salivary gland adenocarcinoma, supporting whole-body FDG-PET/CT in the primary diagnostic work-up in these patients.
|
|
| 10. |
- Flygare, Lennart, 1961-, et al.
(author)
-
Imaging paranasal sinus disease
- 2001
-
In: Oral and Maxillofacial Surgery Clinics of North America. ; 13:4, s. 639-655
-
Journal article (other academic/artistic)abstract
- In short, a proper diagnostic strategy for radiologic investigation of the nose and sinuses is suggested as follows: 1. CR remain useful for the detection of disease. 2. CT is appropriate for trauma, anomalies, recurrent inflammatory conditions, preoperative, and postoperative evaluation. 3. CT MR imaging should be used for mapping of tumors.
|
|
