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- Kalman, Janos L, et al.
(author)
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Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.
- 2019
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In: Bipolar disorders. - : Wiley. - 1399-5618 .- 1398-5647. ; 21:1, s. 68-75
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Journal article (peer-reviewed)abstract
- Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients.A total of 1995 BD type 1 patients from the Consortium of Lithium Genetics (ConLiGen), PsyCourse and Bonn-Mannheim samples were genotyped and their BD and SCZ polygenic risk scores (PRSs) were calculated using the summary statistics of the Psychiatric Genomics Consortium as a training data set. AAO was either separated into onset groups of clinical interest (childhood and adolescence [≤18years] vs adulthood [>18years]) or considered as a continuous measure. The associations between BD- and SCZ-PRSs and AAO were evaluated with regression models.BD- and SCZ-PRSs were not significantly associated with age at disease onset. Results remained the same when analyses were stratified by site of recruitment.The current study is the largest conducted so far to investigate the association between the cumulative BD and SCZ polygenic risk and AAO in BD patients. The reported negative results suggest that such a polygenic influence, if there is any, is not large, and highlight the importance of conducting further, larger scale studies to obtain more information on the genetic architecture of this clinically relevant phenotype.
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| 3. |
- Barthelmie, R., Larsen, G., Bergström, H., Magnusson, M., Schlez,W., Rados, K., Lange, B., Vølund, P., Neckelmann, S., Christensen, L., Schepers, G., Hegberg, T., Folkerts, L.
(author)
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ENDOW:Efficient Development of Offshore Windfarms.
- 2002
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In: Wind Engineering. ; 25:5, s. 263-270
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Journal article (peer-reviewed)
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| 6. |
- Folkerts, M. A., et al.
(author)
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Predicted and user perceived heat strain using the ClimApp mobile tool for individualized alert and advice
- 2021
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In: Climate Risk Management. - : Elsevier BV. - 2212-0963. ; 34
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Journal article (peer-reviewed)abstract
- Thermal models and indices integrated into a mobile application could provide relevant information regarding thermal stress and strain to the general public. The aim of the current paper is to validate such a mobile application, ClimApp, to the users needs in the heat. ClimApp combines weather data with personal user data, thermal models and indices to estimate the thermal strain of the user. The output of ClimApp ranges from −4 to +4, where values below 0 indicate cold strain and values above 0 indicate heat strain. 134 Participants filled in the required personal settings into the app, and indicated if the estimated thermal strain by ClimApp matched their thermal perception. 45 of the participants filled in a user satisfaction questionnaire. Results show that ClimApp is able to predict the heat strain of the user, but may underestimate perceived heat strain when ambient temperature increases. Furthermore, participants were positive about the user-friendliness of ClimApp, but did not think they would use ClimApp frequently and believed the information was irrelevant for them. This is quite remarkable as the number of heat illness cases are increasing and the negative effects of heat occur in all populations exposing themselves to the heat. There needs to be more focus on making people aware of the negative health risks of the heat. ClimApp could play a role as a tool to make heat warnings more accessible for everyone and make people aware of appropriate behavior during periods with high ambient temperatures.
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| 7. |
- Kingma, B. R.M., et al.
(author)
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Climapp—integrating personal factors with weather forecasts for individualised warning and guidance on thermal stress
- 2021
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In: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 18:21
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Journal article (peer-reviewed)abstract
- This paper describes the functional development of the ClimApp tool (available for free on iOS and Android devices), which combines current and 24 h weather forecasting with individual information to offer personalised guidance related to thermal exposure. Heat and cold stress assessments are based on ISO standards and thermal models where environmental settings and personal factors are integrated into the ClimApp index ranging from −4 (extremely cold) to +4 (extremely hot), while a range of −1 and +1 signifies low thermal stress. Advice for individuals or for groups is available, and the user can customise the model input according to their personal situation, including activity level, clothing, body characteristics, heat acclimatisation, indoor or outdoor situation, and geographical location. ClimApp output consists of a weather summary, a brief assessment of the thermal situation, and a thermal stress warning. Advice is provided via infographics and text depending on the user profile. ClimApp is available in 10 languages: English, Danish, Dutch, Swedish, Norwegian, Hellenic (Greek), Italian, German, Spanish and French. The tool also includes a research functionality providing a platform for worker and citizen science projects to collect individual data on physical thermal strain and the experienced thermal strain. The application may therefore improve the translation of heat and cold risk assessments and guidance for subpopulations. ClimApp provides the framework for personalising and downscaling weather reports, alerts and advice at the personal level, based on GPS location and adjustable input of individual factors.
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