| 1. |
- de Zwarte, Sonja M. C., et al.
(författare)
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Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder
- 2022
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Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 414-430
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Tidskriftsartikel (refereegranskat)abstract
- First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 × 10-5 ), with weak evidence of IQ reductions among BD-FDRs (d = -0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment.
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| 2. |
- Fornieles-Callejon, J., et al.
(författare)
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Extremely low frequency band station for natural electromagnetic noise measurement
- 2015
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Ingår i: Radio Science. - 0048-6604 .- 1944-799X. ; 50:3, s. 191-201
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Tidskriftsartikel (refereegranskat)abstract
- A new permanent ELF measurement station has been deployed in Sierra Nevada, Spain. It is composed of two magnetometers, oriented NS and EW, respectively. At 10 Hz, their sensitivity is 19 V/pT and the signal-to-noise ratio (SNR) is 28 dB for a time-varying signal of 1 pT, the expected field amplitude in Sierra Nevada. The station operates for frequencies below 24 Hz. The magnetometers, together with their corresponding electronics, have been specifically designed to achieve such an SNR for small signals. They are based on high-resolution search coils with ferromagnetic core and 10(6) turns, operating in limited geometry configuration. Different system noise sources are considered, and a study of the SNR is also included. Finally, some initial Schumann resonance measurements are presented in order to validate the performance of the measurement station, including 1 h length spectra, daily variations of resonance amplitudes and frequencies for the different seasons, and a 3 day spectrogram.
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| 3. |
- Toledo-Redondo, S., et al.
(författare)
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Solar Wind-Magnetosphere Coupling During Radial Interplanetary Magnetic Field Conditions : Simultaneous Multi-Point Observations
- 2021
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Ingår i: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 126:11
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Tidskriftsartikel (refereegranskat)abstract
- In-situ spacecraft missions are powerful assets to study processes that occur in space plasmas. One of their main limitations, however, is extrapolating such local measurements to the global scales of the system. To overcome this problem at least partially, multi-point measurements can be used. There are several multi-spacecraft missions currently operating in the Earth's magnetosphere, and the simultaneous use of the data collected by them provides new insights into the large-scale properties and evolution of magnetospheric plasma processes. In this work, we focus on studying the Earth's magnetopause (MP) using a conjunction between the Magnetospheric Multiscale and Cluster fleets, when both missions skimmed the MP for several hours at distant locations during radial interplanetary magnetic field (IMF) conditions. The observed MP positions as a function of the evolving solar wind conditions are compared to model predictions of the MP. We observe an inflation of the magnetosphere (similar to 0.7 R-E), consistent with magnetosheath pressure decrease during radial IMF conditions, which is less pronounced on the flank (<0.2 R-E). There is observational evidence of magnetic reconnection in the subsolar region for the whole encounter, and in the dusk flank for the last portion of the encounter, suggesting that reconnection was extending more than 15 R-E. However, reconnection jets were not always observed, suggesting that reconnection was patchy, intermittent or both. Shear flows reduce the reconnection rate up to similar to 30% in the dusk flank according to predictions, and the plasma beta enhancement in the magnetosheath during radial IMF favors reconnection suppression by the diamagnetic drift.
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| 4. |
- Cortese, S., et al.
(författare)
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The future of child and adolescent clinical psychopharmacology: A systematic review of phase 2, 3, or 4 randomized controlled trials of pharmacologic agents without regulatory approval or for unapproved indications
- 2023
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Ingår i: Neuroscience and Biobehavioral Reviews. - : Elsevier BV. - 0149-7634. ; 149
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Tidskriftsartikel (refereegranskat)abstract
- We aimed to identify promising novel medications for child and adolescent mental health problems. We systematically searched https://clinicaltrials.gov/ and https://www.clinicaltrialsregister.eu/ (from 01/01/ 2010-08/23/2022) for phase 2 or 3 randomized controlled trials (RCTs) of medications without regulatory approval in the US, Europe or Asia, including also RCTs of dietary interventions/probiotics. Additionally, we searched phase 4 RCTs of agents targeting unlicensed indications for children/adolescents with mental health disorders. We retrieved 234 ongoing or completed RCTs, including 26 (11%) with positive findings on & GE; 1 primary outcome, 43 (18%) with negative/unavailable results on every primary outcome, and 165 (70%) without publicly available statistical results. The only two compounds with evidence of significant effects that
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| 5. |
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| 6. |
- Solanes, A, et al.
(författare)
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Combining MRI and clinical data to detect high relapse risk after the first episode of psychosis
- 2022
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Ingår i: Schizophrenia (Heidelberg, Germany). - : Springer Science and Business Media LLC. - 2754-6993. ; 8:1, s. 100-
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Tidskriftsartikel (refereegranskat)abstract
- Detecting patients at high relapse risk after the first episode of psychosis (HRR-FEP) could help the clinician adjust the preventive treatment. To develop a tool to detect patients at HRR using their baseline clinical and structural MRI, we followed 227 patients with FEP for 18–24 months and applied MRIPredict. We previously optimized the MRI-based machine-learning parameters (combining unmodulated and modulated gray and white matter and using voxel-based ensemble) in two independent datasets. Patients estimated to be at HRR-FEP showed a substantially increased risk of relapse (hazard ratio = 4.58, P < 0.05). Accuracy was poorer when we only used clinical or MRI data. We thus show the potential of combining clinical and MRI data to detect which individuals are more likely to relapse, who may benefit from increased frequency of visits, and which are unlikely, who may be currently receiving unnecessary prophylactic treatments. We also provide an updated version of the MRIPredict software.
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| 7. |
- de Zwarte, Sonja M. C., et al.
(författare)
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The association between familial risk and brain abnormalities is disease specific : an ENIGMA-relatives study of schizophrenia and bipolar disorder
- 2019
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Ingår i: Biological Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 86:7, s. 545-556
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects.METHODS: We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects.RESULTS: FDRs-BD had significantly larger ICV (d = +0.16, q < .05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = -0.12, q < .05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d < -0.09, q < .05 corrected); and third ventricle was larger (d = +0.15, q < .05 corrected). The findings were not explained by psychopathology in the relatives or control subjects.CONCLUSIONS: Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories leading to brain anomalies in schizophrenia or bipolar disorder are distinct.
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| 8. |
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| 9. |
- Toledo-Redondo, Sergio, et al.
(författare)
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Full 3-D TLM simulations of the Earth-ionosphere cavity : Effect of conductivity on the Schumann resonances
- 2016
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Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 121:6, s. 5579-5593
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Tidskriftsartikel (refereegranskat)abstract
- Schumann resonances can be found in planetary atmospheres, inside the cavity formed by the conducting surface of the planet and the lower ionosphere. They are a powerful tool to investigate both the electric processes that occur in the atmosphere and the characteristics of the surface and the lower ionosphere. Results from a full 3-D model of the Earth-ionosphere electromagnetic cavity based on the Transmission-Line Modeling (TLM) method are presented. A Cartesian scheme with homogeneous cell size of 10 km is used to minimize numerical dispersion present in spherical schemes. Time and frequency domain results have been obtained to study the resonance phenomenon. The effect of conductivity on the Schumann resonances in the cavity is investigated by means of numerical simulations, studying the transition from resonant to nonresonant response and setting the conductivity limit for the resonances to develop inside the cavity. It is found that the transition from resonant to nonresonant behavior occurs for conductivity values above roughly 10(-9) S/m. For large losses in the cavity, the resonances are damped, but, in addition, the peak frequencies change according to the local distance to the source and with the particular electromagnetic field component. These spatial variations present steep variations around each mode's nodal position, covering distances around 1/4 of the mode wavelength, the higher modes being more sensitive to this effect than the lower ones. The dependence of the measured frequency on the distance to the source and particular component of the electric field offers information on the source generating these resonances.
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| 10. |
- Cortese, Samuele, et al.
(författare)
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Psychopharmacology in children and adolescents: unmet needs and opportunities
- 2024
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Ingår i: The Lancet Psychiatry. - 2215-0366 .- 2215-0374. ; 11:2, s. 143-154
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Forskningsöversikt (refereegranskat)abstract
- Psychopharmacological treatment is an important component of the multimodal intervention approach to treating mental health conditions in children and adolescents. Currently, there are many unmet needs but also opportunities, alongside possible risks to consider, regarding the pharmacological treatment of mental health conditions in children and adolescents. In this Position Paper, we highlight and address these unmet needs and opportunities, including the perspectives of clinicians and researchers from the European College of Neuropsychopharmacology–Child and Adolescent Network, alongside those of experts by lived experience from national and international associations, via a survey involving 644 participants from 13 countries, and of regulators, through representation from the European Medicines Agency. We present and discuss the evidence base for medications currently used for mental disorders in children and adolescents, medications in the pipeline, opportunities in the development of novel medications, crucial priorities for the conduct of future clinical studies, challenges and opportunities in terms of the regulatory and legislative framework, and innovations in the way research is conducted, reported, and promoted.
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