| 1. |
- Sumaila, U. Rashid, et al.
(author)
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WTO must ban harmful fisheries subsidies
- 2021
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Journal article (other academic/artistic)
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| 2. |
- Cardoso, Evelin, et al.
(author)
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A Heuristic Approach for the Design of UAV-Based Disaster Relief in Optical Metro Networks
- 2020
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In: International Conference on Transparent Optical Networks. - 2162-7339. - 9781728184234 ; 2020-July, s. 1-5
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Conference paper (peer-reviewed)abstract
- We propose a novel algorithm to dimension the backup elements in an optical metro network, by considering the adoption of Unmanned Aerial Vehicles (UAVs) and wireless interfaces to realize backup wireless links. Our key idea is to efficiently find the set of node pairs that have to be connected by means of multi-hop UAV-based wireless links, which are selected based on the simulation of multiple disaster events. Results, obtained over a set of meaningful scenarios, demonstrate that our solution can greatly reduce the total installation costs compared to a naive approach, which is instead solely tailored to the restoration of the disrupted links in a given disaster scenario.
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| 3. |
- Fresard, Laure, et al.
(author)
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Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts
- 2019
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In: Nature Medicine. - : NATURE PUBLISHING GROUP. - 1078-8956 .- 1546-170X. ; 25:6, s. 911-919
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Journal article (peer-reviewed)abstract
- It is estimated that 350 million individuals worldwide suffer from rare diseases, which are predominantly caused by mutation in a single gene(1). The current molecular diagnostic rate is estimated at 50%, with whole-exome sequencing (WES) among the most successful approaches(2-5). For patients in whom WES is uninformative, RNA sequencing (RNA-seq) has shown diagnostic utility in specific tissues and diseases(6-8). This includes muscle biopsies from patients with undiagnosed rare muscle disorders(6,9), and cultured fibroblasts from patients with mitochondrial disorders(7). However, for many individuals, biopsies are not performed for clinical care, and tissues are difficult to access. We sought to assess the utility of RNA-seq from blood as a diagnostic tool for rare diseases of different pathophysiologies. We generated whole-blood RNA-seq from 94 individuals with undiagnosed rare diseases spanning 16 diverse disease categories. We developed a robust approach to compare data from these individuals with large sets of RNA-seq data for controls (n = 1,594 unrelated controls and n = 49 family members) and demonstrated the impacts of expression, splicing, gene and variant filtering strategies on disease gene identification. Across our cohort, we observed that RNA-seq yields a 7.5% diagnostic rate, and an additional 16.7% with improved candidate gene resolution.
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| 4. |
- Natalino, Carlos, Dr. 1987-, et al.
(author)
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Dimensioning Optical Clouds with Shared-Path Shared-Computing (SPSC) Protection
- 2015
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In: High Performance Switching and Routing (HPSR), 2015 IEEE 16th International Conference on. - : IEEE conference proceedings.
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Conference paper (peer-reviewed)abstract
- Service relocation represents a promising strategy to provide flexible and resource efficient resiliency from link failures in the optical cloud environment. However, when a failure affects a node hosting a datacenter (DC), service relocation from the affected DC is not possible. One alternative to protect against DC failures relies on using design strategies that duplicate the IT (i.e., storage and processing) resources in a backup DC at the expense of increasing resource overbuild (i.e., cost) of the network. This work proposes a dimensioning strategy based on the shared-path shared-computing (SPSC) concept able to protect against any single link, server, or DC failure scenario with minimal resource overbuild for the network and IT infrastructures. SPSC is based on the intuition that only storage units need complete replication in backup DC, while processing units can be instantiated only after the occurrence of a failure, leaving the design strategy some leeway to minimize their number. As result, the proposed SPSC design shows a considerable reduction in the amount of backup resources when compared to the dedicated protection strategies.
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| 5. |
- Natalino, Carlos, 1987-, et al.
(author)
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Lifetime-Aware Provisioning in Green Optical Backbone Networks
- 2016
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In: 2016 OPTICAL FIBER COMMUNICATIONS CONFERENCE AND EXHIBITION (OFC). - Washington, D.C. : Optical Society of America.
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Conference paper (peer-reviewed)abstract
- We present a framework able to limit the device lifetime degradation in optical backbone networks using sleep-mode-based green strategies. Results show that our approach manages the lifetime while not compromising significantly the energy saving performance.
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| 6. |
- Natalino, Carlos, 1987-, et al.
(author)
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Restoration in Optical Cloud Networks With Relocation and Services Differentiation
- 2016
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In: Journal of Optical Communications and Networking. - : Optical Society of America. - 1943-0620 .- 1943-0639. ; 8:2, s. 100-111
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Journal article (peer-reviewed)abstract
- Optical cloud networks allow for the integrated management of both optical and IT resources. In this paradigm, cloud services can be provisioned in an anycast fashion; i.e., only the source node asking for a service is specified, while it is up to the cloud control/management system to select the most suitable destination data center (DC) node. During the cloud service provisioning process, resiliency is crucial in order to guarantee continuous network operations also in the presence of failures. On the one hand, a survivability strategy needs to be able to meet the availability requirements of each specific cloud service, while on the other hand it must be efficient in using backup resources. This paper proposes a restoration-based survivability strategy, which combines the benefits of both cloud service relocation and service differentiation concepts. The former is used to enhance the restorability performance (i.e., the percentage of successfully restored cloud services) offered by restoration, while the latter ensures that critical services are given the proper consideration while backup resources are assigned. The paper proposes both an integer linear programming (ILP) formulation, which guarantees optimal results, and a heuristic, which trades the optimality of the solution achieved by the ILP for faster processing times. Simulation results show that the average service availability and restorability performance obtained by both the ILP and the heuristic are very close to that achievable using a protection-based strategy, but with the inherent benefit, in terms of efficient use of resources, offered by a restoration-based approach.
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| 7. |
- Berg, Sylvia E., 1986-, et al.
(author)
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Heterogeneous vesiculation of 2011 El Hierro xeno-pumice revealed by X-ray computed microtomography
- 2016
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In: Bulletin of Volcanology. - : Springer Science and Business Media LLC. - 0258-8900 .- 1432-0819. ; 78:12
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Journal article (peer-reviewed)abstract
- During the first week of the 2011 El Hierro submarine eruption, abundant light-coloured pumiceous, high-silica volcanic bombs coated in dark basanite were found floating on the sea. The composition of the light-coloured frothy material ('xeno-pumice') is akin to that of sedimentary rocks from the region, but the textures resemble felsic magmatic pumice, leaving their exact mode of formation unclear. To help decipher their origin, we investigated representative El Hierro xeno-pumice samples using X-ray computed microtomography for their internal vesicle shapes, volumes, and bulk porosity, as well as for the spatial arrangement and size distributions of vesicles in three dimensions (3D). We find a wide range of vesicle morphologies, which are especially variable around small fragments of rock contained in the xeno-pumice samples. Notably, these rock fragments are almost exclusively of sedimentary origin, and we therefore interpret them as relicts an the original sedimentary ocean crust protolith(s). The irregular vesiculation textures observed probably resulted from pulsatory release of volatiles from multiple sources during xeno-pumice formation, most likely by successive release of pore water and mineral water during incremental heating and decompression of the sedimentary protoliths.
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| 8. |
- Carracedo, Juan Carlos, et al.
(author)
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The 2011-2012 submarine eruption off El Hierro, Canary Islands : New lessons in oceanic island growth and volcanic crisis management
- 2015
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In: Earth-Science Reviews. - : Elsevier BV. - 0012-8252 .- 1872-6828. ; 150, s. 168-200
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Journal article (peer-reviewed)abstract
- Forty years after the eruption of the Teneguía volcano on La Palma, 1971, the last volcanic event in the Canary Islands, a submarine eruption took place in 2011 off-shore El Hierro, the smallest and youngest island of the archipelago. In this paper, we review the periods of seismic unrest leading up to the 2011–2012 El Hierro eruption, the timeline of eruptive events, the erupted products, the wider societal impacts, and the insights garnered for our understanding of ocean island growth mechanisms and hazard management. Seismic precursors allowed early detection of magmatic activity and prediction of the approximate location of the eruption. White coloured “floating stones” (“xeno-pumice”) were described within the first few days of the events, the origin of which were hotly debated because of their potential implications for the character of the eruption. Due to epistemic uncertainty derived from delayed flow of scientific information and equivocal interpretations of the “floating stones”, the El Hierro 2011–2012 events were characterised by cautious civil protection measures, which greatly impacted on the residents' lives and on the island's economy. We therefore summarise the scientific lessons learned from this most recent Canary Island eruption and discuss how emergency managers might cope with similar situations of uncertainty during future eruptive events in the region.
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| 9. |
- Clark, Andrew G., et al.
(author)
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Evolution of genes and genomes on the Drosophila phylogeny
- 2007
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
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Journal article (peer-reviewed)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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| 10. |
- Day, James M. D., et al.
(author)
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Mantle source characteristics and magmatic processes during the 2021 La Palma eruption
- 2022
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In: Earth and Planetary Science Letters. - : Elsevier. - 0012-821X .- 1385-013X. ; 597
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Journal article (peer-reviewed)abstract
- The 2021 eruption of La Palma (September 19-December 13) was the first subaerial eruption in the Canary Islands in 50 years. Approximately 0.2 km3 of lava erupted from a newly formed, broadly basaltic composite volcanic edifice on the northwestern flank of the Cumbre Vieja volcanic ridge. Comprehensive sampling of the olivine-and clinopyroxene-phyric lavas over the eruption period reveals temporal changes in mineralogy and bulk rock geochemistry from tephrite to basanite. Initial tephrite lavas have low MgO (-6 wt.%) and elevated TiO2 (-4 wt.%) and contain amphibole crystals and gabbroic micro -xenoliths. In contrast, lavas with progressively more mafic compositions erupted to approximately day 20 of the eruption and thereafter remained as basanite (-8 wt.% MgO; 3.7 wt.% TiO2) until eruption termination. Temporal changes in lava chemistry reflect initial eruption of fractionated magmas that crystallized 5-10% olivine and clinopyroxene, as well as minor spinel, sulfide, and magnetite, followed by later eruption of deeper-sourced and more primitive magma. Vanadium-in-olivine oxybarometry indicates parental magmas were oxidized (fO2 = +1.5 to +2 FMQ) with 8.2 +/- 0.8 wt.% MgO and were generated from between 2.5-3% partial melting of a mantle source potentially containing a pyroxenite component (Xpx = 0.31 +/- 0.12). Day 1-20 tephrites have more radiogenic 187Os/188Os (0.143-0.148) and lower Pd, Pt, Ir and Os contents than post day 20 basanites (187Os/188Os = 0.141-0.145). Combined with available seismic data, the lavas provide a high-resolution record of eruptive evolution. Initial fractionated tephrite magma was stored in the upper lithosphere up to four years prior to eruption, consistent with pre-cursor seismicity and the presence of partially reacted amphibole and micro-xenoliths. The later lavas of the eruption were fed by more primitive basanitic parental magmas that were likely sourced from the deeper portion of the magma storage system that is underplating the island. Precursor events to the 2021 La Palma eruption involved seismicity and magma emplacement, storage and differentiation, which was followed by mobilisation, eruption, and eventual exhaustion of stored magma and partial melts. This magmatic progression is similar to that documented from the 1949 and 1971 Cumbre Vieja eruptions. Ocean islands with limited basaltic magma supply show similarities to the magmatic evolution observed in large silicic systems, where initial magma emplacement and differentiation is followed by later magma remobilisation that induces volcanic activity.
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