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Träfflista för sökning "WFRF:(Fraser T. J.) "

Search: WFRF:(Fraser T. J.)

  • Result 1-10 of 239
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1.
  • 2021
  • swepub:Mat__t
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2.
  • Tabiri, S, et al. (author)
  • 2021
  • swepub:Mat__t
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3.
  • Bravo, L, et al. (author)
  • 2021
  • swepub:Mat__t
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4.
  • Glasbey, JC, et al. (author)
  • 2021
  • swepub:Mat__t
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5.
  • 2021
  • swepub:Mat__t
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7.
  • Acharya, B. S., et al. (author)
  • Introducing the CTA concept
  • 2013
  • In: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
  • Journal article (other academic/artistic)abstract
    • The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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9.
  • Blokland, G. A. M., et al. (author)
  • Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
  • 2022
  • In: Biological Psychiatry. - : Elsevier BV. - 0006-3223 .- 1873-2402. ; 91:1, s. 102-117
  • Journal article (peer-reviewed)abstract
    • Background: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. Methods: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Results: Across disorders, genome-wide significant single nucleotide polymorphism–by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10−8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10−6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10−7; rs73033497, p = 8.8 × 10−7; rs7914279, p = 6.4 × 10−7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10−7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10−7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10−7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). Conclusions: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels. © 2021 Society of Biological Psychiatry
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  • Result 1-10 of 239
Type of publication
journal article (221)
research review (5)
conference paper (3)
book chapter (3)
reports (2)
Type of content
peer-reviewed (223)
other academic/artistic (11)
Author/Editor
Fraser, M. (98)
Smartt, S. J. (52)
Inserra, C. (48)
Kankare, E. (48)
Pastorello, A. (45)
Valenti, S. (40)
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Sollerman, Jesper (39)
Young, D. R. (39)
Elias-Rosa, N. (38)
Benetti, S. (37)
Maguire, K. (35)
Kotak, R. (34)
Smith, K. W. (33)
Mattila, S. (32)
Gal-Yam, A. (30)
Botticella, M. T. (26)
Nicholl, M. (26)
Galbany, L. (25)
Chen, T.-W. (25)
Cappellaro, E. (23)
Gromadzki, M. (23)
Smith, M. (20)
Howell, D. A. (20)
Pignata, G. (20)
Wyrzykowski, L. (20)
Jonker, P. G. (19)
Sullivan, M (19)
Kuncarayakti, H. (18)
Turatto, M. (18)
Taubenberger, S. (18)
Walton, N. A. (17)
Lundqvist, Peter (16)
Taddia, Francesco (16)
Stefansson, K (16)
Anderson, J. P. (16)
Jerkstrand, A. (16)
Wevers, T. (16)
Lopes, L. (15)
Della Valle, M. (15)
Nothen, MM (15)
Stritzinger, M. D. (15)
Chambers, K. C. (14)
Rest, A. (14)
Gutierrez, C. P. (14)
Leloudas, G. (14)
Patel, M (14)
Campbell, H (14)
Morris, D. (14)
Ochner, P. (14)
Hodgkin, S. T. (14)
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University
Stockholm University (91)
Karolinska Institutet (86)
Uppsala University (80)
Lund University (46)
University of Gothenburg (31)
Umeå University (19)
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Högskolan Dalarna (11)
Luleå University of Technology (10)
Royal Institute of Technology (7)
Linköping University (6)
Chalmers University of Technology (6)
Swedish University of Agricultural Sciences (5)
Linnaeus University (4)
Stockholm School of Economics (2)
Malmö University (1)
Mid Sweden University (1)
Södertörn University (1)
Karlstad University (1)
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Language
English (238)
German (1)
Research subject (UKÄ/SCB)
Natural sciences (119)
Medical and Health Sciences (64)
Engineering and Technology (9)
Social Sciences (6)
Agricultural Sciences (4)
Humanities (1)

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