| 1. |
- Watson, Hunna J., et al.
(author)
-
Common Genetic Variation and Age of Onset of Anorexia Nervosa
- 2022
-
In: BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE. - : Elsevier BV. - 2667-1743. ; 2:4, s. 368-378
-
Journal article (peer-reviewed)abstract
- BACKGROUND: Genetics and biology may influence the age of onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to age of onset of AN and to investigate the genetic associations between age of onset of AN and age at menarche.METHODS: A secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed, which included 9335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age of onset, early-onset AN (,13 years), and typical-onset AN, and genetic correlation, genetic risk score, and Mendelian randomization analyses.RESULTS: Two loci were genome-wide significant in the typical-onset AN GWAS. Heritability estimates (single nucleotide polymorphism-h2) were 0.01-0.04 for age of onset, 0.16-0.25 for early-onset AN, and 0.17-0.25 for typical-onset AN. Early-and typical-onset AN showed distinct genetic correlation patterns with putative risk factors for AN. Specifically, early-onset AN was significantly genetically correlated with younger age at menarche, and typical-onset AN was significantly negatively genetically correlated with anthropometric traits. Genetic risk scores for age of onset and early-onset AN estimated from independent GWASs significantly predicted age of onset. Mendelian randomization analysis suggested a causal link between younger age at menarche and early -onset AN.CONCLUSIONS: Our results provide evidence consistent with a common variant genetic basis for age of onset and implicate biological pathways regulating menarche and reproduction.
|
|
| 2. |
- Boen, Rune, et al.
(author)
-
Beyond the global brain differences : intraindividual variability differences in 1q21.1 distal and 15q11.2 bp1-bp2 deletion carriers
- 2024
-
In: Biological Psychiatry. - 0006-3223 .- 1873-2402. ; 95:2, s. 147-160
-
Journal article (peer-reviewed)abstract
- Background: Carriers of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants exhibit regional and global brain differences compared with noncarriers. However, interpreting regional differences is challenging if a global difference drives the regional brain differences. Intraindividual variability measures can be used to test for regional differences beyond global differences in brain structure.Methods: Magnetic resonance imaging data were used to obtain regional brain values for 1q21.1 distal deletion (n = 30) and duplication (n = 27) and 15q11.2 BP1-BP2 deletion (n = 170) and duplication (n = 243) carriers and matched noncarriers (n = 2350). Regional intra-deviation scores, i.e., the standardized difference between an individual's regional difference and global difference, were used to test for regional differences that diverge from the global difference.Results: For the 1q21.1 distal deletion carriers, cortical surface area for regions in the medial visual cortex, posterior cingulate, and temporal pole differed less and regions in the prefrontal and superior temporal cortex differed more than the global difference in cortical surface area. For the 15q11.2 BP1-BP2 deletion carriers, cortical thickness in regions in the medial visual cortex, auditory cortex, and temporal pole differed less and the prefrontal and somatosensory cortex differed more than the global difference in cortical thickness.Conclusions: We find evidence for regional effects beyond differences in global brain measures in 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants. The results provide new insight into brain profiling of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants, with the potential to increase understanding of the mechanisms involved in altered neurodevelopment.
|
|
| 3. |
- Kaufmann, Tobias, et al.
(author)
-
Common brain disorders are associated with heritable patterns of apparent aging of the brain
- 2019
-
In: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 22:10, s. 1617-
-
Journal article (peer-reviewed)abstract
- Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
|
|
| 4. |
- Frei, Karin M., et al.
(author)
-
Was it for walrus? : Viking Age settlement and medieval walrus ivory trade in Iceland and Greenland
- 2015
-
In: World archaeology. - : Informa UK Limited. - 0043-8243 .- 1470-1375. ; 47:3, s. 439-466
-
Journal article (peer-reviewed)abstract
- Walrus-tusk ivory and walrus-hide rope were highly desired goods in Viking Age north-west Europe. New finds of walrus bone and ivory in early Viking Age contexts in Iceland are concentrated in the south-west, and suggest extensive exploitation of nearby walrus for meat, hide and ivory during the first century of settlement. In Greenland, archaeofauna suggest a very different specialized long-distance hunting of the much larger walrus populations in the Disko Bay area that brought mainly ivory to the settlement areas and eventually to European markets. New lead isotopic analysis of archaeological walrus ivory and bone from Greenland and Iceland offers a tool for identifying possible source regions of walrus ivory during the early Middle Ages. This opens possibilities for assessing the development and relative importance of hunting grounds from the point of view of exported products.
|
|
| 5. |
- Prevéy, Janet S., et al.
(author)
-
The tundra phenology database: more than two decades of tundra phenology responses to climate change
- 2022
-
In: Arctic Science. - : Canadian Science Publishing. - 2368-7460. ; 8:3, s. 1026-1039
-
Journal article (peer-reviewed)abstract
- Observations of changes in phenology have provided some of the strongest signals of the effects of climate change on terrestrial ecosystems. The International Tundra Experiment (ITEX), initiated in the early 1990s, established a common protocol to measure plant phenology in tundra study areas across the globe. Today, this valuable collec-tion of phenology measurements depicts the responses of plants at the colder extremes of our planet to experimental and ambient changes in temperature over the past decades. The database contains 150 434 phenology observations of 278 plant species taken at 28 study areas for periods of 1–26 years. Here we describe the full data set to increase the visibility and use of these data in global analyses and to invite phenology data contributions from underrepresented tundra locations. Portions of this tundra phenology database have been used in three recent syntheses, some data sets are expanded, others are from entirely new study areas, and the entirety of these data are now available at the Polar Data Catalogue (https://doi.org/10.21963/13215).
|
|
| 6. |
- Frei, Karin M, et al.
(author)
-
Mapping human mobility during the third and second millennia BC in present-day Denmark
- 2019
-
In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 14:8
-
Journal article (peer-reviewed)abstract
- We present results of the largest multidisciplinary human mobility investigation to date of skeletal remains from present-day Denmark encompassing the 3rd and 2nd millennia BC. Through a multi-analytical approach based on 88 individuals from 37 different archaeological localities in which we combine strontium isotope and radiocarbon analyses together with anthropological investigations, we explore whether there are significant changes in human mobility patterns during this period. Overall, our data suggest that mobility of people seems to have been continuous throughout the 3rd and 2nd millennia BC. However, our data also indicate a clear shift in mobility patterns from around 1600 BC onwards, with a larger variation in the geographical origin of the migrants, and potentially including more distant regions. This shift occurred during a transition period at the beginning of the Nordic Bronze Age at a time when society flourished, expanded and experienced an unprecedented economic growth, suggesting that these aspects were closely related.
|
|
| 7. |
- Bergerbrant, Sophie, 1968, et al.
(author)
-
Identifying commoners in the Bronze Age: burials outside barrows
- 2017
-
In: New Perspectives on the Bronze Age: Proceedings from the 13th Nordic Bronze Age Symposium, held in Gothenburg 9th June to 13th June 2015. - Oxford : Archaeopress. - 9781784915988 ; , s. 37-64
-
Book chapter (other academic/artistic)abstract
- This article discusses the possibility of social division and the presence of commoners in south Scandinavia during the Early Bronze Age. The discussion is based on new scientific and archaeological data generated in the project Travels, transmissions and transformations in temperate northern Europe during the 3rd and 2nd millennium BC: The rise of Bronze Age societies. Based on a comprehensive radiocarbon dating program, we were able to re-assign many skeletons, previously assumed to be Late Neolithic, to the Bronze Age. This accounted for a significant proportion of non-elite burials (including those of children) that had previously been ‘mysteriously’ missing in the archaeological Bronze Age record. Moreover, strontium isotope analyses reveal that individuals seem to be mobile regardless of their wealth status and burial rituals. It suggests a society where workers and perhaps even nonfree labourers were mobile, not only the elite segment.
|
|
| 8. |
- Blank, Malou, 1975, et al.
(author)
-
Mobility patterns in inland southwestern Sweden during the Neolithic and Early Bronze Age
- 2021
-
In: Archaeological and Anthropological Sciences. - : Springer Science and Business Media LLC. - 1866-9557 .- 1866-9565. ; 13
-
Journal article (peer-reviewed)abstract
- In this paper, we investigate population dynamics in the Scandinavian Neolithic and Early Bronze Age in southwestern Sweden. Human mobility patterns in Falbygden were studied by applying strontium isotope analysis combined with archaeological and bioarchaeological data, including mtDNA and sex assessment on a large dataset encompassing 141 individuals from 21 megalithic graves. In combination with other archaeological and anthropological records, we investigated the temporal and spatial scale of individual movement, mobility patterns of specific categories of people and possible social drivers behind them. Our results of strontium and biomolecular analyses suggest that mobility increased in the Late Neolithic and Early Bronze Age compared to the earlier parts of the Neolithic. The data indicate individuals moving both into and away from Falbygden. Mobility patterns and contact networks also shift over time.
|
|
| 9. |
- Elphinstone, Cassandra, et al.
(author)
-
Multiple Pleistocene refugia for Arctic Bell-Heather revealed with genomic analyses of modern and historic plants
- 2024
-
In: Journal of Biogeography. - 0305-0270 .- 1365-2699.
-
Journal article (peer-reviewed)abstract
- Aim: Arctic plants survived the Pleistocene glaciations in unglaciated refugia. The number, ages, and locations of these refugia are often unclear. We use high-resolution genomic data from present-day and Little-Ice-Age populations of Arctic Bell-Heather to re-evaluate the biogeography of this species and determine whether it had multiple independent refugia or a single refugium in Beringia. Location: Circumpolar Arctic and Coastal British Columbia (BC) alpine. Taxon: Cassiope tetragona L., subspecies saximontana and tetragona, outgroup C. mertensiana (Ericaceae). Methods: We built genotyping-by-sequencing (GBS) libraries using Cassiope tetragona tissue from 36 Arctic locations, including two ~250- to 500-year-old populations collected under glacial ice on Ellesmere Island, Canada. We assembled a de novo GBS reference to call variants. Population structure, genetic diversity and demography were inferred from PCA, ADMIXTURE, fastsimcoal2, SplitsTree, and several population genomics statistics. Results: Population structure analyses identified 4–5 clusters that align with geographic locations. Nucleotide diversity was highest in Beringia and decreased eastwards across Canada. Demographic coalescent analyses dated the following splits with Alaska: BC subspecies saximontana (5 mya), Russia (~1.4 mya), Europe (>200–600 kya), and Greenland (~60 kya). Northern Canada populations appear to have formed during the current interglacial (7–9 kya). Admixture analyses show genetic variants from Alaska appear more frequently in present-day than historic plants on Ellesmere Island. Conclusions: Population and demographic analyses support BC, Alaska, Russia, Europe and Greenland as all having had independent Pleistocene refugia. Northern Canadian populations appear to be founded during the current interglacial with genetic contributions from Alaska, Europe and Greenland. We found evidence, on Ellesmere Island, for continued recent gene flow in the last 250–500 years. These results suggest that a re-analysis of other Arctic species with shallow population structure using higher resolution genomic markers and demographic analyses may help reveal deeper structure and other circumpolar glacial refugia.
|
|
| 10. |
- Kristiansen, Kristian, 1948, et al.
(author)
-
Re-theorising mobility and the formation of culture and language among the Corded Ware Culture in Europe
- 2017
-
In: Antiquity. - : Antiquity Publications. - 0003-598X .- 1745-1744. ; 91:356, s. 334-347
-
Journal article (peer-reviewed)abstract
- Copyright © 2017 Antiquity Publications Ltd.Recent genetic, isotopic and linguistic research has dramatically changed our understanding of how the Corded Ware Culture in Europe was formed. Here the authors explain it in terms of local adaptations and interactions between migrant Yamnaya people from the Pontic-Caspian steppe and indigenous North European Neolithic cultures. The original herding economy of the Yamnaya migrants gradually gave way to new practices of crop cultivation, which led to the adoption of new words for those crops. The result of this hybridisation process was the formation of a new material culture, the Corded Ware Culture, and of a new dialect, Proto-Germanic. Despite a degree of hostility between expanding Corded Ware groups and indigenous Neolithic groups, stable isotope data suggest that exogamy provided a mechanism facilitating their integration. This article should be read in conjunction with that by Heyd (2017, in this issue).
|
|
