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1.	Hasselblatt, Martin, et al. (author) Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant : A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC 2022 In: Neuropathology and Applied Neurobiology. - : John Wiley & Sons. - 0305-1846 .- 1365-2990. ; 48:4 Journal article (peer-reviewed)abstract Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant, is a histopathological distinct low-grade lesion encountered in older children and young adults that shows epigenetic similarity with ATRT-MYC and has the potential for malignant progression.
2.	Hasselblatt, Martin, et al. (author) Hippo Signaling is Essential for the Phenotype Associated with Snr1 Loss in Drosophila Melanogastera and Involved in the Biology of Smarcb1-Deficient Atypical Teratoid/Rhabdoid Tumors 2014 In: Neuro-Oncology. - 1522-8517 .- 1523-5866. ; 16, s. 3-4 Journal article (other academic/artistic)
3.	Jeibmann, Astrid, et al. (author) Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster 2014 In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5, s. 4005- Journal article (peer-reviewed)abstract Atypical teratoid/rhabdoid tumours (AT/RT) are malignant brain tumours. Unlike most other human brain tumours, AT/RT are characterized by inactivation of one single gene, SMARCB1. SMARCB1 is a member of the evolutionarily conserved SWI/SNF chromatin remodelling complex, which has an important role in the control of cell differentiation and proliferation. Little is known, however, about the pathways involved in the oncogenic effects of SMARCB1 inactivation, which might also represent targets for treatment. Here we report a comprehensive genetic screen in the fruit fly that revealed several genes not yet associated with loss of snr1, the Drosophila homologue of SMARCB1. We confirm the functional role of identified genes (including merlin, kibra and expanded, known to regulate hippo signalling pathway activity) in human rhabdoid tumour cell lines and AT/RT tumour samples. These results demonstrate that fly models can be employed for the identification of clinically relevant pathways in human cancer.

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Type of publication: journal article (3)

Type of content: peer-reviewed (2); other academic/artistic (1)

Author/Editor: Kool, Marcel (3); Hasselblatt, Martin (3); Fruehwald, Michael C ... (3); Paulus, Werner (3); Pfister, Stefan M. (2); Koos, Björn (2); show more...; Jeibmann, Astrid (2); Eikmeier, Kristin (2); Linge, Anna (2); Bartelheim, Kerstin (2); Casar Borota, Oliver ... (1); Siebert, Reiner (1); Hellström, Mats (1); Hartmann, Christian (1); Johann, Pascal (1); Thomas, Christian (1); Federico, Aniello (1); Bens, Susanne (1); Kordes, Uwe (1); Neumann, Julia E. (1); Dottermusch, Matthia ... (1); Rodriguez, Fausto J. (1); Lo, Andrea C. (1); Cheng, Sylvia (1); Hendson, Glenda (1); Hukin, Juliette (1); Koch, Arend (1); Capper, David (1); Nemes, Karolina (1); Johann, Pascal D. (1); Schulz, Jacqueline (1); Albrecht, Stefanie (1); show less...

University: Uppsala University (3)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (3)

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