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- Ortiz-Casas, Brandon, et al.
(author)
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Bio-acceptable 0D and 1D ZnO nanostructures for cancer diagnostics and treatment
- 2021
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In: Materials Today. - : Elsevier. - 1369-7021 .- 1873-4103. ; 50, s. 533-569
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Journal article (peer-reviewed)abstract
- As bioapplications of 0D and 1D zinc oxide (ZnO) seem a recent development, they have brought many exciting proposals showing exquisite signs as sensors and assay platforms offering biomolecular selectivity and sensitivity for cancer diagnosis and treatment. Cancer researchers are looking for diagnostic and molecular instruments to identify the cancer-causing agents and subtle molecular shifts. The inclusion of high-performance ZnO materials due to their intrinsic properties such as viability, bio-acceptability, high isoelectric point, tunable morphology, etc., is promising for targeted detection and treatment processes. More specifically, ZnO nanowires (NWs) have offered the opportunity to yield new types of approaches against targeted cancer in contrast to their 0D counterparts. The ability of ZnO NW sensors to identify the molecular features (i.e., biomarker) of cancer and their integration portability has the potential to revolutionize cancer diagnosis and patient health monitoring timely and efficiently. Despite being robust, tunable properties based on surface chemistry and eco-friendly, scalable opportunities are yet to be explored. This review considers captivating research advances to identify and understand fundamental properties and examine various biosensing approaches and nanomedicine (via performing targeted drug delivery or therapeutic) aspects utilizing them while paying attention to different size regimes of ZnO NWs. The high-performance role of 0D and 1D ZnO as biosensors, capture devices, cell imaging complexes, or treatment is addressed on the bases of the controlled functions such as enhanced adsorption, reactivity, surface chemistry, cytotoxicity, and biocompatibility in various biological systems and models. With a comparative viewpoint, 0D and 1D ZnO nanostructures are going to emerge as breakthrough candidates for diagnostics and treatment of cancer effectively and efficiently.
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| 2. |
- Gonzalez-Garnica, Marisol, et al.
(author)
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One dimensional Au-ZnO hybrid nanostructures based CO2 detection : Growth mechanism and role of the seed layer on sensing performance
- 2021
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In: Sensors and actuators. B, Chemical. - : Elsevier. - 0925-4005 .- 1873-3077. ; 337
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Journal article (peer-reviewed)abstract
- In the present research, hybrid Au-ZnO one-dimensional (1-D) nanostructures were grown on silicon substrates with an Al-doped ZnO (AZO) seed layer (Ultrasonic Spray Pyrolysis: USP grown) and no seed layer (NSL) using two different catalytic gold films of 2 nm and 4 nm, respectively. Consequently, such 1-D nanostructures growth was associated with the vapor-liquid-solid (VLS) and vapor-solid (VS) processes. Scanning electron microscopy (SEM) imaging analysis confirms that heat treatment triggered Au nanoparticles nucleation with varying diameters. The Au nanoparticles size and underneath seed layer texture strongly affect the morphology and aspect ratio of 1-D ZnO nanostructures. The seed layer (1-D USP) sample resulted in the growth of longer nanowires (NWs) with a high aspect ratio. The NSL sample showed the formation of nanorods (NRs) with a low aspect ratio mainly via VS growth process. X-ray diffraction (XRD), X-Ray photoelectron spectroscopy (XPS), and photoluminescence (PL) analysis also revealed the differences in the NWs and NRs properties and confirmed VLS and VS growth mechanisms. CO2 gas sensing performance at different concentrations was demonstrated, and NWs with seed layer showed a relatively higher sensing response. In contrast, NSL samples (NRs) exhibited two times faster response. A detailed gas sensing mechanism with different CO2 adsorption modes based on properties of 1D nanostructures has been discussed. Currently, CO2 sensing and capturing are critical topics in the green transition framework. The present work would be of high significance to the scientific field of NW growth and fulfill the urgent need for CO2 gas sensing.
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