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Träfflista för sökning "WFRF:(Ganeshram Abiarchana) "

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1.	Pandey, Gaurav Kumar, et al. (author) The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation. 2014 In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 26:5, s. 722-737 Journal article (peer-reviewed)abstract Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of neuroblastoma. CpG methylation and a high-risk neuroblastoma associated SNP on chromosome 6p22 functionally contribute to NBAT-1 differential expression. Loss of NBAT-1 increases cellular proliferation and invasion. It controls these processes via epigenetic silencing of target genes. NBAT-1 loss affects neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST. Thus, loss of NBAT-1 contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors.
2.	Pandey, Gaurav Kumar, et al. (author) Transcriptomic profiling of primary neuroblastomas revealsa high-risk tumor associated long noncoding RNA NBAT1, with functional roles in cell proliferation and neuronal differentiation. Other publication (other academic/artistic)

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Type of publication: other publication (1); journal article (1)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Kogner, Per (2); Mitra, Sanhita (2); Pandey, Gaurav Kumar (2); Ganeshram, Abiarchan ... (2); Martinsson, Tommy, 1 ... (1); Abrahamsson, Jonas, ... (1); show more...; Fransson, Susanne, 1 ... (1); Abrahamsson, Jonas (1); Larsson, Erik (1); Kanduri, Chandrasekh ... (1); Kanduri, Chandrasekh ... (1); Larsson, Erik, 1975 (1); Akyürek, Levent, 196 ... (1); Bandaru, Sashidar (1); Mishra, Kankadeb, 19 ... (1); Kanduri, Meena, 1974 (1); Subhash, Santhilal, ... (1); Mondal, Tanmoy, 1981 (1); Östensson, Malin, 19 ... (1); Martinsson, Tommy (1); Fischer, Matthias (1); Pfeifer, Susan (1); Fransson, Susanne (1); Hedborg, Fredrik (1); Shi, Leming (1); Mishra, Kankadeb (1); Pfeifer, Susan, 1948 ... (1); Subhash, Santhilal (1); Mondal, Tanmoy (1); Kanduri, Meena (1); Hertwig, Falk (1); Peng, Zhiyu (1); Hedborg, Fredrik, 19 ... (1); show less...

University: Uppsala University (2); University of Gothenburg (1); Chalmers University of Technology (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

Year: 2014 (1)

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