| 1. |
- Tabiri, S, et al.
(author)
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- 2021
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swepub:Mat__t
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| 2. |
- Bravo, L, et al.
(author)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
- Signori, A, et al.
(author)
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Heterogeneity on long-term disability trajectories in patients with secondary progressive MS: a latent class analysis from Big MS Data network
- 2023
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In: Journal of neurology, neurosurgery, and psychiatry. - : BMJ. - 1468-330X .- 0022-3050. ; 94:1, s. 23-30
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Journal article (peer-reviewed)abstract
- Over the decades, several natural history studies on patients with primary (PPMS) or secondary progressive multiple sclerosis (SPMS) were reported from international registries. In PPMS, a consistent heterogeneity on long-term disability trajectories was demonstrated. The aim of this study was to identify subgroups of patients with SPMS with similar longitudinal trajectories of disability over time.MethodsAll patients with MS collected within Big MS registries who received an SPMS diagnosis from physicians (cohort 1) or satisfied the Lorscheider criteria (cohort 2) were considered. Longitudinal Expanded Disability Status Scale (EDSS) scores were modelled by a latent class growth analysis (LCGA), using a non-linear function of time from the first EDSS visit in the range 3–4.ResultsA total of 3613 patients with SPMS were included in the cohort 1. LCGA detected three different subgroups of patients with a mild (n=1297; 35.9%), a moderate (n=1936; 53.6%) and a severe (n=380; 10.5%) disability trajectory. Median time to EDSS 6 was 12.1, 5.0 and 1.7 years, for the three groups, respectively; the probability to reach EDSS 6 at 8 years was 14.4%, 78.4% and 98.3%, respectively. Similar results were found among 7613 patients satisfying the Lorscheider criteria.ConclusionsContrary to previous interpretations, patients with SPMS progress at greatly different rates. Our identification of distinct trajectories can guide better patient selection in future phase 3 SPMS clinical trials. Additionally, distinct trajectories could reflect heterogeneous pathological mechanisms of progression.
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| 5. |
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| 6. |
- Aarestrup, FM, et al.
(author)
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Towards a European health research and innovation cloud (HRIC)
- 2020
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In: Genome medicine. - : Springer Science and Business Media LLC. - 1756-994X. ; 12:1, s. 18-
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Journal article (peer-reviewed)abstract
- The European Union (EU) initiative on the Digital Transformation of Health and Care (Digicare) aims to provide the conditions necessary for building a secure, flexible, and decentralized digital health infrastructure. Creating a European Health Research and Innovation Cloud (HRIC) within this environment should enable data sharing and analysis for health research across the EU, in compliance with data protection legislation while preserving the full trust of the participants. Such a HRIC should learn from and build on existing data infrastructures, integrate best practices, and focus on the concrete needs of the community in terms of technologies, governance, management, regulation, and ethics requirements. Here, we describe the vision and expected benefits of digital data sharing in health research activities and present a roadmap that fosters the opportunities while answering the challenges of implementing a HRIC. For this, we put forward five specific recommendations and action points to ensure that a European HRIC: i) is built on established standards and guidelines, providing cloud technologies through an open and decentralized infrastructure; ii) is developed and certified to the highest standards of interoperability and data security that can be trusted by all stakeholders; iii) is supported by a robust ethical and legal framework that is compliant with the EU General Data Protection Regulation (GDPR); iv) establishes a proper environment for the training of new generations of data and medical scientists; and v) stimulates research and innovation in transnational collaborations through public and private initiatives and partnerships funded by the EU through Horizon 2020 and Horizon Europe.
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| 7. |
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| 8. |
- Berné, O., et al.
(author)
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Formation of the methyl cation by photochemistry in a protoplanetary disk
- 2023
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In: Nature. - 0028-0836 .- 1476-4687. ; 621:7977, s. 56-59
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Journal article (peer-reviewed)abstract
- Forty years ago, it was proposed that gas-phase organic chemistry in the interstellar medium can be initiated by the methyl cation CH3+ (refs. 1–3), but so far it has not been observed outside the Solar System 4,5. Alternative routes involving processes on grain surfaces have been invoked 6,7. Here we report James Webb Space Telescope observations of CH3+ in a protoplanetary disk in the Orion star-forming region. We find that gas-phase organic chemistry is activated by ultraviolet irradiation.
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| 9. |
- Hacker, B. R., et al.
(author)
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Thermochronology of the Talkeetna intraoceanic arc of Alaska: Ar/Ar, U-Th/He, Sm-Nd, and Lu-Hf dating
- 2011
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In: Tectonics. - 0278-7407. ; 30
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Journal article (peer-reviewed)abstract
- As one of two well-exposed intraoceanic arcs, the Talkeetna arc of Alaska affords an opportunity to understand processes deep within arcs. This study reports new Lu-Hf and Sm-Nd garnet ages, Ar-40/Ar-39 hornblende, mica and whole-rock ages, and U-Th/He zircon and apatite ages from the Chugach Mountains, Talkeetna Mountains, and Alaska Peninsula, which, in conjunction with existing geochronology, constrain the thermal history of the arc. Zircon U-Pb ages establish the main period of arc magmatism as 202-181 Ma in the Chugach Mountains and 183-153 Ma in the eastern Talkeetna Mountains and Alaska Peninsula. Approximately 184 Ma Lu-Hf and similar to 182 Ma Sm-Nd garnet ages indicate that 25-35 km deep sections of the arc remained above similar to 700 degrees C for as much as 15 Myr. The Ar-40/Ar-39 hornblende ages are chiefly 194-170 Ma in the Chugach Mountains and 175-150 Ma in the Talkeetna Mountains and Alaska Peninsula but differ from zircon U-Pb ages in the same samples by as little as 0 Myr and as much as 33 Myr, documenting a spatially variable thermal history. Mica ages have a broader distribution, from similar to 180 Ma to 130 Ma, suggesting local cooling and/or reheating. The oldest U-Th/He zircon ages are similar to 137 to 129 Ma, indicating no Cenozoic regional heating above similar to 180 degrees C. Although the signal is likely complicated by Cretaceous and Oligocene postarc magmatism, the aggregate thermochronology record indicates that the thermal history of the Talkeetna arc was spatially variable. One-dimensional finite difference thermal models show that this kind of spatial variability is inherent to intraoceanic arcs with simple construction histories. Citation: Hacker, B. R., P. B. Kelemen, M. Rioux, M. O. McWilliams, P. B. Gans, P. W. Reiners, P. W. Layer, U. Soderlund, and J. D. Vervoort (2011), Thermochronology of the Talkeetna intraoceanic arc of Alaska: Ar/Ar, U-Th/He, Sm-Nd, and Lu-Hf dating, Tectonics, 30, TC1011, doi:10.1029/2010TC002798.
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| 10. |
- Heath, E., et al.
(author)
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Inter-laboratory exercise on steroid estrogens in aqueous samples
- 2010
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In: Environmental Pollution. - : Elsevier BV. - 0269-7491 .- 1873-6424. ; 158:3, s. 658-662
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Journal article (peer-reviewed)abstract
- An inter-laboratory comparison exercise was organized among European laboratories, under the aegis of EU COST Action 636: ""Xenobiotics in Urban Water Cycle"" The objective was to evaluate the performance of testing laboratories determining ""Endocrine Disrupting Compounds"" (EDC) in various aqueous matrices. As the main task three steroid estrogens. 17 alpha-ethinylestradiol, 17 beta-estradiol and estrone were determined in four spiked aqueous matrices' tap water, river water and wastewater treatment plant influent and effluent using GC-MS and LC-MS/MS Results were compared and discussed according to the analytical techniques applied, the accuracy and reproducibility of the analytical methods and the nature of the sample matrices. Overall, the results obtained in this inter-laboratory exercise reveal a high level of competence among the participating laboratories for the detection of steroid estrogens in water samples indicating that GC-MS as well as LC-MS/MS can equally be employed for the analysis of natural and synthetic hormones.
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