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- Glimelius, Bengt, et al.
(author)
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A window of opportunity phase II study of enzastaurin in chemonaive patients with asymptomatic metastatic colorectal cancer
- 2010
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In: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 21:5, s. 1020-1026
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Journal article (peer-reviewed)abstract
- BACKGROUND: Preclinically, protein kinase C and AKT activation can be inhibited by enzastaurin and reduce tumor growth of colorectal cancer cells. In asymptomatic patients with metastatic colorectal cancer (mCRC), enzastaurin activity was evaluated by measuring the 6-month progression-free survival (PFS) rate in a window study design. PATIENTS AND METHODS: Chemonaive patients with asymptomatic mCRC who did not require immediate chemotherapy-induced tumor reduction received a 400-mg thrice daily loading dose of enzastaurin on day 1 of cycle 1, followed by 500 mg once daily for the remaining 28-day cycles. Progression was assessed on the basis of radiographic imaging, rise in carcinoembryonic antigen or lactate dehydrogenase (LDH) levels or by appearance of clinical symptoms. RESULTS: Twenty-eight patients received daily enzastaurin. The 6-month PFS rate was 28% [95% confidence interval (CI) 13%-45%] and median PFS was 1.9 months (95% CI 1.8-4.5 months). Twelve (43%) patients had stable disease with a median duration of 6.1 months. The survival rate at 20 months was 77% (95% CI 47%-92%). No grade 4 toxicity was reported and grade 3 toxic effects were observed in three patients with one patient showing probable drug-related elevation of liver transaminases. CONCLUSION: The window design in asymptomatic patients with mCRC can be safely applied to assess the activity and safety of novel cytostatic agents like enzastaurin.
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- Ivashina, Marianna, 1975, et al.
(author)
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System noise performance of ultra-wideband feeds for future radio telescopes: Conical-Sinuous Antenna and Eleven Antenna
- 2014
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In: 2014 31th URSI General Assembly and Scientific Symposium, URSI GASS 2014, Beijing, China, 16-23 August 2014. - 9781467352253 ; , s. Art. no. 6930063-
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Conference paper (peer-reviewed)abstract
- Next generation radio telescopes can greatly benefit from reflector antenna feeds that demonstrate very wide frequency bandwidth and can potentially realize low noise performance of the receivers. In this paper, we provide an overview of the current developments at the national radio observatories in Sweden and USA that make use of novel multi-port antenna feeds, such as the Sinuous Antenna and Eleven Antenna. The focus of this overview is on the system performance, when using this technology at high or very low frequencies, i.e. when the feed-receiver system is fully or partially (cryogenically) cooled.
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