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- Dittrich, Anna, 1972, et al.
(author)
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Plasma and CSF NfL are differentially associated with biomarker evidence of neurodegeneration in a community-based sample of 70-year-olds
- 2022
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In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. - : Wiley. - 2352-8729. ; 14:1
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Journal article (peer-reviewed)abstract
- Neurofilament light protein (NfL) in cerebrospinal fluid (CSF) and plasma (P) are suggested to be interchangeable markers of neurodegeneration. However, evidence is scarce from community-based samples. NfL was examined in a small-scale sample of 287 individuals from the Gothenburg H70 Birth cohort 1944 study, using linear models in relation to CSF and magnetic resonance imaging (MRI) biomarker evidence of neurodegeneration. CSF-NfL and P-NfL present distinct associations with biomarker evidence of Alzheimer's disease (AD) pathology and neurodegeneration. P-NfL was associated with several markers that are characteristic of AD, including smaller hippocampal volumes, amyloid beta (A beta)(42), A beta(42/40), and A beta(42)/t-tau (total tau). CSF-NfL demonstrated associations with measures of synaptic and neurodegeneration, including t-tau, phosphorylated tau (p-tau), and neurogranin. Our findings suggest that P-NfL and CSF-NfL may exert different effects on markers of neurodegeneration in a small-scale community-based sample of 70-year-olds.
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| 2. |
- Jägerup, S. B., et al.
(author)
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Silicic frothy xenoliths (xeno-pumice) in recent volcanics from Gran Canaria, Canary Islands
- 2023
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In: Journal of Volcanology and Geothermal Research. - : Elsevier BV. - 0377-0273 .- 1872-6097. ; 440
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Journal article (peer-reviewed)abstract
- The Quaternary small-volume alkaline magmatic episode on Gran Canaria erupted dominantly basanite and nephelinite lavas and scoria deposits that contain a range of mantle and crustal xenoliths. These xenoliths comprise peridotite nodules, partially melted plutonic and volcanic rock fragments, and a group of light colored, felsic, and commonly frothy quartz-bearing rock fragments (xeno-pumice) that show evidence for intense interaction with their host magmas. Here we study a selection of these felsic and, in part, glassy and vesicular xenoliths from North and North-East Gran Canaria, with the aim to unravel their ultimate origin and learn more about magma storage and ascent within and below the island. Inspection of textures, mineral assemblages and glass compositions reveal one group of felsic xenoliths with fresh to partly altered igneous phenocryst assemblages and relict magmatic textures in addition to 818O values of 3.6 to 6.6%o. This group is interpreted to be of igneous origin. A second group of frothy felsic xenoliths displays mineralogy and textural characteristics more similar to sedimentary rocks with frequent occurrence of quartz, a mineral usually not present as phenocrysts in magmatic rocks from the Canary Islands. This second group displays relatively high 818O values (8.1 to 16.8%o), more typical for sedimentary lithologies, and is thus interpreted to represent material derived from the extensive pre-island sedimentary part of the ocean crust. The investigated xenoliths from North Gran Canaria thus provide a snapshot of pre-island sedimentary geology as well as the island's "magmatic" interior. These new data help constrain the available subsurface compositional variations within and below the Canary Islands and will hence be useful in interpreting magma evolution trends and magma storage levels.
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| 3. |
- Troll, Valentin R., et al.
(author)
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Sacred ground; the Maipés necropolis of north-west Gran Canaria : the Maipés necropolis of north-west Gran Canaria
- 2019
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In: Geology Today. - : Wiley. - 0266-6979. ; 35:2, s. 55-62
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Journal article (peer-reviewed)abstract
- Gran Canaria, like most of the Canary Islands, shows evidence for young basaltic volcanism in the form of cinder cones and valley-hugging lava flows. These landforms were of no particular use to the aboriginal population, nor to the subsequent Spanish settlers, and young lava flows and lava fields are still referred to as ‘malpaÃs’ (badlands) in the Canary Islands. In north-west Gran Canaria, one such lava flow fills the bottom of a steep-sided valley, which reaches the sea at the present day village of Agaete. The lava flow erupted c. 3030 ± 90 yr bp and displays a total length of ∌ 11 km. At its distal end, just outside Agaete, it hosts one of Europe’s largest and most important pre-historic burial sites constructed of volcanic rock: the Maipés necropolis. Over 700 pre-historic tombs (or tumuli) constructed from the aa-type clinker materials have been identified on top of the valley-filling lava flow. The up to soccer-ball sized vesicular clinker fragments are sufficiently low in density to provide abundant, workable basalt blocks for the construction of the tumuli, allowing the pre-hispanic aboriginal population to create a large and magnificent ‘sacred ground’ in an otherwise barren landscape.
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