| 1. |
- Engert, Andreas, et al.
(author)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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In: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Journal article (peer-reviewed)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 2. |
- Arndt, D. S., et al.
(author)
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STATE OF THE CLIMATE IN 2017
- 2018
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In: Bulletin of The American Meteorological Society - (BAMS). - : American Meteorological Society. - 0003-0007 .- 1520-0477. ; 99:8, s. S1-S310
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Research review (peer-reviewed)
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| 3. |
- Nicolas, Aude, et al.
(author)
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Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
- 2018
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In: Neuron. - : Cell Press. - 0896-6273 .- 1097-4199. ; 97:6, s. 1268-1283.e6
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Journal article (peer-reviewed)abstract
- To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.
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| 4. |
- Frejd, Peter, 1973-, et al.
(author)
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Exploring the notion of mathematical literacy in school curriculum documents
- 2017
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In: Mathematical Modelling and Applications. - Cham : Springer. - 9783319629674 - 9783319629681 ; , s. 255-263
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Book chapter (peer-reviewed)abstract
- The notion of mathematical literacy has gained momentum internationally during recent time through the influence of the Programme of International Student Assessment and national concerns about the ability of citizens to use mathematics effectively in in person, civic and work life. Accordingly, it is to be expected that these concerns should be reflected in relevant curriculum documents. This chapter presents a content analysis of a sample of 12 national curricula documents in relation to mathematical literacy. The analysis shows that there does not appear to be general agreement about the definition and of mathematical literacy within the analysed documents. We conclude the chapter by considering the implications for practice of the identified variations in understandings of mathematical literacy internationally.
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| 5. |
- Geiger, Vincent, et al.
(author)
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A reflection on mathematical modelling and applications as a field of research : theoretical orientation and diversity
- 2015
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In: <em>Mathematical modelling in education research and practice: Cultural, Social and Cognitive Influences</em>. - Cham : Springer. - 9783319182711 - 9783319182728 ; , s. 161-171
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Book chapter (peer-reviewed)abstract
- This chapter explores the nature of theoretical approaches used in research literature focusing on mathematical applications and modelling, in particular, the orientation and diversity of theoretical approaches within this line of enquiry within the field of mathematical modelling and applications. The study is based on the document analysis of a sample of publications over the past decade. The study indicates that there is an increasing diversity of theoretical approaches utilised within mathematical modelling and applications but that publications appear to draw on a limited range of theories.
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| 6. |
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| 7. |
- Sá, Jacinto, et al.
(author)
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Transient mid-IR study of electron dynamics in TiO2 conduction band.
- 2013
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In: The Analyst. - : Royal Society of Chemistry (RSC). - 0003-2654 .- 1364-5528. ; 138:7, s. 1966-70
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Journal article (peer-reviewed)abstract
- The dynamics of TiO2 conduction band electrons were followed with a novel broadband synchrotron-based transient mid-IR spectroscopy setup. The lifetime of conduction band electrons was found to be dependent on the injection method used. Direct band gap excitation results in a lifetime of 2.5 ns, whereas indirect excitation at 532 nm via Ru-N719 dye followed by injection from the dye into TiO2 results in a lifetime of 5.9 ns.
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| 8. |
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| 9. |
- Schwiegelshohn, Uwe, et al.
(author)
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Perspectives on grid computing
- 2010
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In: Future generations computer systems. - : Elsevier BV. - 0167-739X .- 1872-7115. ; 26:8, s. 1104-1115
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Journal article (peer-reviewed)abstract
- Grid computing has been the subject of many large national and international IT projects. However, not all goals of these projects have been achieved. In particular. the number of users lags behind the initial forecasts laid out by proponents of grid technologies. This underachievement may have led to claims that the grid concept as a whole is on its way to being replaced by Cloud computing and various X-as-a-Service approaches. In this paper, we try to analyze the current situation and to identify promising directions for future grid development. Although there are shortcomings in current grid systems, we are convinced that the concept as a whole remains valid and can benefit from new developments, including Cloud computing. Furthermore, we strongly believe that some future applications will require the grid approach and that, as a result, further research is required in order to turn this concept into reliable, efficient and user-friendly computing platforms. (c) 2010 Elsevier B.V. All rights reserved.
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| 10. |
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