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- Moore, K. L. F., et al.
(author)
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Improved survival in myeloma patients-a nationwide registry study of 4,647 patients=75 years treated in Denmark and Sweden
- 2023
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In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 108:6, s. 1640-1651
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Journal article (peer-reviewed)abstract
- The prevalence of multiple myeloma (MM) is increasing in Nordic countries and the rest of the western world. Patients aged =75 years at diagnosis constitute an increasing proportion of all MM patients, but are underrepresented in randomized clinical trials. There is an urgent need for studies of the characteristics, treatment and outcome in this cohort. We present data from two nationwide population-based registries of all MM patients diagnosed in Denmark from January 1, 2005 until February 18, 2020, and in Sweden from January 1, 2008 until December 31, 2019, including treatment data for patients diagnosed until 2018 (Denmark) and 2019 (Sweden). In total 4,647 patients were =75 years at diagnosis, compared to 7,378 younger patients. Patients =75 years, accounting for approximately 40% of all MM patients, are a distinct cohort with more advanced disease at diagnosis, reflected by higher International Staging System (ISS) stage, and a higher proportion have renal failure and anemia. We found a more gradual introduction of modern medications in the older cohort than in the younger, despite simultaneous changes in guidelines. Compared to the cohorts in randomized controlled trials that guide the treatment of non-transplant eligible patients, we found a higher proportion of patients =75 years and presenting with ISS III in the real-world populations. Nevertheless, response rates and survival are increasing, indicating that modern treatment regimens are effective and well tolerated also in elderly MM patients in real-world populations.
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- Andersson, C., et al.
(author)
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Fully electric ship propulsion reduces airborne noise but not underwater noise
- 2024
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In: Ocean Engineering. - Göteborg : Elsevier. - 0029-8018 .- 1873-5258. ; 302
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Journal article (peer-reviewed)abstract
- Electrification of ships offers zero-emission travel and is spreading rapidly, but the relation between electric ship propulsion and noise pollution is not generally understood. Here, three different types of diesel-electric hybrid ferries have been measured in two operating modes: running in hybrid mode with the diesel engine powering an electric generator; and running in fully electric battery powered mode. Measurements were performed to simultaneously quantify airborne and underwater radiated noise. Findings are that on-board diesel engines for electricity generation do not contribute a large extent of the underwater radiated noise, whilst a major source of airborne low-frequency radiation.
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- Blimark, Cecilie, et al.
(author)
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Outcome and survival of myeloma patients diagnosed 2008-2015. Real-world data on 4904 patients from the Swedish Myeloma Registry
- 2018
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In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 103:3, s. 506-513
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Journal article (peer-reviewed)abstract
- Epidemiology and outcome of myeloma are mainly reported from large university centers and collaborative groups, and do not represent 'real-world' patients. The Swedish Myeloma Registry is a prospective population-based registry documenting characteristics, treatment and outcome in newly diagnosed myeloma, including asymptomatic and localized forms, with the purpose of improving disease management and outcome. This report presents information on patients diagnosed between 2008 and 2015, including data on first-line treatment in patients diagnosed up to 2014, with a follow up until December 2016. We present age-adjusted incidence, patients' characteristics at baseline, treatment, response, and survival. Baseline data were available with a 97% coverage in 4904 patients (median age 71 years, males 70 years, females 73 years; 72% were 65 years or older), and at 1-year follow up in 3558 patients with symptomatic disease (92% of patients initially reported). The age-adjusted incidence was 6.8 myeloma cases per 100,000 inhabi-ants per year. Among initially symptomatic patients (n= 3988), 77% had osteolytic lesions or compression fractures, 49% had anemia, 18% impaired kidney function, and 13% hypercalcemia. High-dose therapy with autologous stem cell transplantation was given to 77% of patients aged up to 66 years, and to 22% of patients aged 66-70 years. In the study period, 68% received bortezomib, thalidomide, and/or lenalidomide as part of the first-line treatment, rising from 31% in 2008 to 81% in 2014. In active myeloma, the median relative survival of patients aged 65 years or under was 7.7 years, and 3.4 years in patients aged 66 years and over. Patients diagnosed with myeloma in more recent years were associated with significantly higher rates of complete or very good partial remission (P<0.05), and with a significantly higher survival, with a Hazard Ratio (HR) of 0.84 (95% CI: 0.77-0.92; P<0.05). There was a small, but significant survival benefit in patients treated at university hospitals (HR 0.93; 95% CI: 0.87-0.99; P<0.05). We report here on a near complete 'real-world' population of myeloma patients during an 8-year period; a period in which newer drugs were implemented into standard practice. The overall incidence and median age were both higher than in most previous studies, indicating a more complete coverage of older patients. Myeloma survival in Sweden is comparable to other large registry studies, and responses and survival improved during the study period.
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- Genell, Anders, 1974, et al.
(author)
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Components in evaluation of complex interior truck sounds
- 2006
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In: Journal of Low Frequency Noise and Vibration. - 0263-0923. ; 25:4, s. 227-237
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Journal article (peer-reviewed)abstract
- In order to investigate influences on assessment of interior truck sounds two experiments have been carried out with emphasis on the low frequency content. In the first experiment the participants were presented with recorded sound from the interior of a truck cabin, with different alterations of the low frequency content. In the second experiment the balance between low and high frequency content was altered for the recorded sounds. Three main dimensions important for the assessment of truck sounds were found: an Annoyance factor, a Wakefulness factor and a Quality factor. Additionally it was found that a wellsuited spectral balance could improve positive impressions of truck sound.
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