| 1. |
- Abelev, Betty, et al.
(author)
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Long-range angular correlations on the near and away side in p-Pb collisions at root S-NN=5.02 TeV
- 2013
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In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 719:1-3, s. 29-41
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Journal article (peer-reviewed)abstract
- Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and expressed as associated yield per trigger particle. Two long-range ridge-like structures, one on the near side and one on the away side, are observed when the per-trigger yield obtained in low-multiplicity events is subtracted from the one in high-multiplicity events. The excess on the near-side is qualitatively similar to that recently reported by the CMS Collaboration, while the excess on the away-side is reported for the first time. The two-ridge structure projected onto azimuthal angle is quantified with the second and third Fourier coefficients as well as by near-side and away-side yields and widths. The yields on the near side and on the away side are equal within the uncertainties for all studied event multiplicity and p(T) bins, and the widths show no significant evolution with event multiplicity or p(T). These findings suggest that the near-side ridge is accompanied by an essentially identical away-side ridge. (c) 2013 CERN. Published by Elsevier B.V. All rights reserved.
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| 2. |
- Abelev, Betty, et al.
(author)
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Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC
- 2012
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In: Journal of High Energy Physics. - 1029-8479. ; :7
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Journal article (peer-reviewed)abstract
- We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.
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| 3. |
- Abelev, Betty, et al.
(author)
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Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV
- 2012
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In: Journal of High Energy Physics. - 1029-8479. ; :11
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Journal article (peer-reviewed)abstract
- The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.
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| 4. |
- Gianni, Andrea, et al.
(author)
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Bainitic steel grade for solid wheels: metallurgical, mechanical and in-service testing
- 2007
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In: Proceedings International Heavy Haul Association Specialist Technical Session (IHHA2007). ; , s. 701-711
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Conference paper (peer-reviewed)abstract
- Bainitic steel grades generally have superior rolling contact and thermal fatigue resistances, but poorer wear characteristics as compared to “conventional” pearlitic steel wheels. To improve wear characteristics the manufacturing process of bainitic materials needs to be carefully controlled.In the current paper, the manufacturing process of the “MICRALOS” bainitic steel grade is described. The main focus is on metallurgical testing activities performed in order to compare the new steel grade to standard pearlitic steels and to predict service behaviour of the solid bainitic wheels. Further, on-going field tests on the iron-ore line between Luleå and Narvik are reported, with details about measurement methods and results.The performance of the wheels is reviewed and compared to the current scientific knowledge of bainitic steel grades and the deterioration of heavy haul wheels. Finally benefits of, and challenges for bainitic wheels in general and for the MICRALOS grade wheels in particular will be discussed.
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| 5. |
- Gianni, Andrea, et al.
(author)
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Bainitic steel grade for solid wheels: metallurgical, mechanical, and in-service testing
- 2009
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In: Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit. - 0954-4097 .- 2041-3017. ; 223:2, s. 163-171
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Journal article (peer-reviewed)abstract
- Bainitic steel grades generally have superior rolling contact and thermal fatigue resistances, but poorer wear characteristics when compared with ‘conventional’ pearlitic steel wheels. To improve the wear characteristics, the manufacturing process of bainitic materials needs to be carefully controlled. In this article, the manufacturing process of the ‘MICRALOS’ bainitic steel grade has been described. The main focus is on metallurgical testing activities performed in order to compare the new steel grade with standard pearlitic steels and to predict the service behaviour of the solid bainitic wheels. Further, on-going field tests on the iron ore line between Luleå and Narvik have been reported, with details about measurement methods and results. The performance of the wheels is reviewed and compared with the current scientific knowledge of bainitic steel grades and the deterioration of heavy haul wheels. Finally, benefits of and challenges for bainitic wheels in general and for the MICRALOS grade wheels in particular will be discussed.
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| 6. |
- Karlsson, Tord, et al.
(author)
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Innovative bainitic steel grade for solid wheels tested in arctic heavy haul operations
- 2006
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In: Proceedings 7th International Conference on Contact Mechanics and Wear of Rail/Wheel Systems. ; , s. 6 pp-
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Conference paper (peer-reviewed)abstract
- The current paper presents the design of, and field tests with bainitic wheels adopted for arctic heavy haul operations. The tests verifies the superior rolling contact and thermal fatigue resistance of bainitic wheels as compared to “conventional” pearlitic steel wheels. Further, it was demonstrated how the inherently poor wear characteristics of bainitic materials may be counteracted by a carefully controlled manufacturing process.
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| 7. |
- Munoz-Gama, Jorge, et al.
(author)
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Process mining for healthcare : Characteristics and challenges
- 2022
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In: Journal of Biomedical Informatics. - : Elsevier BV. - 1532-0464 .- 1532-0480. ; 127
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Journal article (peer-reviewed)abstract
- Process mining techniques can be used to analyse business processes using the data logged during their execution. These techniques are leveraged in a wide range of domains, including healthcare, where it focuses mainly on the analysis of diagnostic, treatment, and organisational processes. Despite the huge amount of data generated in hospitals by staff and machinery involved in healthcare processes, there is no evidence of a systematic uptake of process mining beyond targeted case studies in a research context. When developing and using process mining in healthcare, distinguishing characteristics of healthcare processes such as their variability and patient-centred focus require targeted attention. Against this background, the Process-Oriented Data Science in Healthcare Alliance has been established to propagate the research and application of techniques targeting the data-driven improvement of healthcare processes. This paper, an initiative of the alliance, presents the distinguishing characteristics of the healthcare domain that need to be considered to successfully use process mining, as well as open challenges that need to be addressed by the community in the future.
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| 8. |
- Sclafani, Francesco, et al.
(author)
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Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients
- 2016
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In: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 37:9, s. 852-857
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Journal article (peer-reviewed)abstract
- Single nucleotide polymorphisms (SNPs) in microRNA genes have been associated with colorectal cancer (CRC) risk, survival and response to treatment. Conflicting results are available on the association between rs4919510, a SNP in mature miR-608 and clinical outcome in CRC. Here, we analyzed the association between rs4919510 and benefit from perioperative treatment in a randomised phase II trial of neoadjuvant Capecitabine and Oxaliplatin (CAPOX) followed by chemo-radiotherapy, surgery and adjuvant CAPOX +/- Cetuximab in high-risk locally advanced rectal cancer (LARC). A total of 155/164 (94.5%) patients were assessable. 95 (61.3%) were homozygous for CC, 55 (35.5%) heterozygous (CG) and 5 (3.2%) homozygous for GG. Median follow-up was 64.9 months. In the CAPOX arm the 5-year progression-free survival (PFS) and overall survival (OS) rates were 54.6% and 60.7% for CC and 82.0% and 82.1% for CG/GG, respectively (HR PFS 0.13, 95% CI: 0.12-0.83, P = 0.02; HR OS 0.38, 95% CI: 0.14-1.01, P = 0.05). In the CAPOX-C arm PFS and OS were 73.2 and 82.2%, respectively for CC carriers and 64.6 and 73.1% for CG/GG carriers (HR PFS 1.38, 95% CI: 0.61-3.13, P = 0.44; HR OS 1.34, 95% CI: 0.52-3.48, P = 0.55). An interaction was found between study treatment and rs4919510 genotype for both PFS (P = 0.02) and OS (P = 0.07). This is the first study investigating rs4919510 in LARC. The CC genotype appeared to be associated with worse prognosis compared to the CG/GG genotype in patients treated with chemotherapy and chemo-radiotherapy alone. Addition of Cetuximab to chemotherapy and chemo-radiotherapy in CC carriers appeared to improve clinical outcome.
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