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1.	Dai, KF, et al. (author) HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation 2016 In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6, s. 20987- Journal article (peer-reviewed)abstract The elicitation of HIV-1 broadly neutralizing antibodies following envelope glycoprotein (Env) vaccination is exceedingly difficult. Suboptimal engagement of naïve B cells is suggested to limit these low frequency events, especially at the conserved CD4bs. Here, we analyzed CD4bs-directed monoclonal antibodies (mAbs) elicited by YU2 gp140-foldon trimers in a non-human primate by selective sorting using CD4bs “knock out” trimers. Following two inoculations, the CD4bs-directed mAbs efficiently recognized the eliciting immunogen in their affinity-maturing state but did not recognize CD4bs-defective probes. We reverted these mAbs to their most likely inferred germline (igL) state, leaving the HCDR3 unaltered, to establish correlates of in vitro affinity to in vivo activation. Most igL-reverted mAbs bound the eliciting gp140 immunogen, indicating that CD4bs-directed B cells possessing reasonable affinity existed in the naïve repertoire. We detected relatively high affinities for the majority of the igL mAbs to gp120 and of Fabs to gp140, which, as expected, increased when the antibodies ‘matured’ following vaccination. Affinity increases were associated with slower off-rates as well as with acquisition of neutralizing capacity. These data reveal in vitro binding properties associated with in vivo activation that result in functional archiving of antigen-specific B cells elicited by a complex glycoprotein antigen following immunization.
2.	Dubrovskaya, V, et al. (author) Vaccine-elicited Cross-neutralizing HIV Antibodies (bNAbs) to Two Env Sites of Vulnerability Following Heterologous NFL Trimer Liposome Prime: Boosting 2018 In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - 0889-2229. ; 34, s. 45-45 Conference paper (other academic/artistic)
3.	Martinez-Murillo, P, et al. (author) Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach 2017 In: Immunity. - : Elsevier BV. - 1097-4180 .- 1074-7613. ; 46:5, s. 804- Journal article (peer-reviewed)
4.	Navis, M, et al. (author) HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization 2014 In: PLoS pathogens. - : Public Library of Science (PLoS). - 1553-7374. ; 10:8, s. e1004337- Journal article (peer-reviewed)
5.	Wang, YM, et al. (author) HIV-1 Env Immunogen-elicited Cross-reactive Tier 2 Virus Neutralizing Antibody Response in Non-human Primates 2016 In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - 0889-2229. ; 32, s. 143-143 Conference paper (other academic/artistic)
6.	Dosenovic, P, et al. (author) Analysis of antibody and B cell responses following inoculation with computationally designed HIV-1 2F5 epitope scaffold proteins 2009 In: RETROVIROLOGY. - 1742-4690. ; 6 Conference paper (other academic/artistic)
7.	Dubrovskaya, V, et al. (author) Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response 2017 In: PLoS pathogens. - : Public Library of Science (PLoS). - 1553-7374. ; 13:9, s. e1006614- Journal article (peer-reviewed)
8.	Dubrovskaya, V, et al. (author) Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability 2019 In: Immunity. - : Elsevier BV. - 1097-4180 .- 1074-7613. ; 51:5, s. 915- Journal article (peer-reviewed)
9.	Guenaga, J, et al. (author) Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant 2011 In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 6:1, s. e16074- Journal article (peer-reviewed)
10.	Hedestam, GBK, et al. (author) Evolution of B cell analysis and Env trimer redesign 2017 In: Immunological reviews. - : Wiley. - 1600-065X .- 0105-2896. ; 275:1, s. 183-202 Journal article (peer-reviewed)

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Result 1-10 of 14

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Type of publication: journal article (10); conference paper (4)

Type of content: peer-reviewed (10); other academic/artistic (4)

Author/Editor: Guenaga, J (13); Wyatt, RT (12); Hedestam, GBK (11); Wilson, R (9); Tran, K (6); O'Dell, S (5); show more...; Mascola, JR (5); Feng, Y. (5); Ward, AB (5); Dubrovskaya, V (4); Li, YX (4); Corcoran, M. (3); Wang, YM (3); Movsesyan, A. (3); McKee, K (3); Bernat, NV (3); Sundling, C (3); Bale, S. (3); Lore, K (2); Adori, M (2); Martinez-Murillo, P (2); Yang, LF (2); Baker, D (2); Dosenovic, P (2); Lei, L. (2); Ingale, J (2); Ofek, G (2); Kwong, PD (2); Li, Y. (1); Zhu, J. (1); Torres, J. (1); Wyatt, R (1); Hedestam, GK (1); Koup, RA (1); Phad, G (1); Pancera, M (1); Lindgren, G (1); Wilson, I (1); Stark, JM (1); Stanfield, R (1); Douek, DC (1); Blazar, BR (1); Cottrell, CA (1); Schief, WR (1); Pramanik, L (1); Dai, KF (1); Khan, SN (1); He, LL (1); Pittaluga, S (1); Schief, W (1); show less...

University: Karolinska Institutet (14)

Language: English (14)

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