| 1. |
- André, Benny, et al.
(author)
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Performance and Tribofilm Formation of a Low-Friction Coating Incorporating Inorganic Fullerene Like Nano-Particles
- 2009
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Conference paper (peer-reviewed)abstract
- A new tribological coating with potential as a coating for components for low-friction applications is tested and compared to three, state of the art, commercial low-friction PVD coatings. The new coating is an electrodeposited coating composed by a Ni-P matrix incorporating fullerene like nanoparticles of WS2. The performance of the new coating is compared with three reference coatings in a ball-on-disc setup. The tribological tests involved ball bearing steel balls slid on coated discs, under different conditions of humidity and also with or without oil lubrication. Both mating surfaces were closely investigated in a scanning electron microscope and the low-friction tribofilms formed were further analysed. The correlations found between coefficient of friction, surface roughness of the wear scar, tribofilm formation and contact conditions are discussed. The new coating exhibits a very low coefficient of friction at low humidity, a behaviour closely resembling that of the MoS2-based commercial reference, whereas the carbon based PVD coatings tested exhibit the reversed dependence of humidity. The low-friction behaviour of the new coating is correlated to the formation of a WS2 tribofilm with a superficial alignment of the basal planes parallel to the sliding direction. When lubricated with a base oil, the beneficial tribofilm is not formed and the coefficient of friction is much higher. The results show that even though the coating is an electrodeposited coating it can compete with state of the art commercial PVD coatings.
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| 2. |
- André, Benny, et al.
(author)
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Performance and Tribofilm Formation of a Low-Friction Coating Incorporating Inorganic Fullerene Like Nano-Particles
- 2012
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In: Surface & Coatings Technology. - : Elsevier BV. - 0257-8972 .- 1879-3347. ; 206:8-9, s. 2325-2329
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Journal article (peer-reviewed)abstract
- A new tribological coating with potential as a coating for components for low-friction applications is tested and compared to three, state of the art, commercial low-friction PVD coatings. The new coating is an electrodeposited coating composed by a Ni-P matrix incorporating fullerene like nanoparticles of WS2. The performance of the new coating is compared with three reference coatings in a ball-on-disc setup. The tribological tests involved ball bearing steel balls slid on coated discs, under different conditions of humidity and also with or without oil lubrication. Both mating surfaces were closely investigated in a scanning electron microscope and the low-friction tribofilms formed were further analysed. The correlations found between coefficient of friction, surface roughness of the wear scar, tribofilm formation and contact conditions are discussed. The new coating exhibits a very low coefficient of friction at low humidity, a behaviour closely resembling that of the MoS2-based commercial reference, whereas the carbon based PVD coatings tested exhibit the reversed dependence of humidity. The low-friction behaviour of the new coating is correlated to the formation of a WS2 tribofilm with a superficial alignment of the basal planes parallel to the sliding direction. When lubricated with a base oil, the beneficial tribofilm is not formed and the coefficient of friction is much higher. The results show that even though the coating is an electrodeposited coating it can compete with state of the art commercial PVD coatings.
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| 3. |
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| 4. |
- Bergh, Johanna, et al.
(author)
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No link between viral findings in the prostate and subsequent cancer development
- 2007
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In: British Journal of Cancer. - London : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 96:1, s. 137-139
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Journal article (peer-reviewed)abstract
- In an investigation of 201 prostate tissue samples from patients with benign prostate hyperplasia that later progressed to prostate cancer and 201 matched controls that did not, there were no differences in the prevalence of adenovirus, herpesvirus, papilloma virus, polyoma virus and Candida albicans DNA.
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| 5. |
- Gad, Helge, et al.
(author)
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
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In: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
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Journal article (peer-reviewed)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
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| 6. |
- Gustavsson, Fredrik, 1977-, et al.
(author)
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Nanoparticle based and sputtered WS2 low-friction coatings : differences and similarities with respect to friction mechanisms and tribofilm formation
- 2013
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In: Surface & Coatings Technology. - : Elsevier BV. - 0257-8972 .- 1879-3347. ; 232, s. 616-626
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Journal article (peer-reviewed)abstract
- MoS2 and WS2 are widely known intrinsic low-friction materials that have been extensively used and thoroughly investigated in literature. They are commonly produced in the form of sputtered coatings and show extremely low friction coefficients in non-humid environments, but rapidly degrade in humid conditions. Close nested fullerene-like nanoparticles of these materials have been proposed to have better oxidation resistance due to their closed form with the absence of dangling bonds. In the present study, an electrochemically deposited coating consisting of fullerene-like nanoparticles of WS2 embedded in a Ni-P matrix is tested under various loads and humidity conditions and compared with a sputtered WS2 coating with respect to their tribological behavior. The formation of a tribofilm on both surfaces is known to be crucial for the low-friction mechanism of WS2 and the different mechanisms behind this formation for the two types of coatings are investigated. It is shown that despite the completely different transformation processes, the resulting tribofilms are very similar. This is analyzed thoroughly using SEM, AES and TEM. The friction coefficient is known to be lower at higher normal loads for these materials and in the present study the mechanical and chemical responses of the tribofilm to higher normal loads during sliding are investigated. It was observed that the basal planes become aligned more parallel to the surface at higher loads, and that the tribofilm is less oxidized. It is suggested that these mechanisms are connected and are crucial keys to the wear life of these materials. (C) 2013 Elsevier B.V. All rights reserved.
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| 7. |
- Gustavsson Tingvall, Patrik, et al.
(author)
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Is There Really a Foreign Ownership Wage Premium? : Evidence from Matched Employer-Employee Data
- 2006
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Other publication (other academic/artistic)abstract
- Numerous studies on firm-level data have reported higher average wages in foreign-owned firms than in domestically-owned firms. This, however, does not necessarily imply that the individual worker’s wage increase with foreign ownership. Using detailed matched employer-employee data on the entire Swedish private sector, we examine the effect of foreign ownership on individual wages, controlling for individual and firm heterogeneity as well as for possible selection bias in foreign acquisitions. We distinguish between foreign greenfields and takeovers and compare foreign owned firms with both domestic multinationals and local firms. Our results show a considerably smaller wage premium in foreign owned firms than what has been found in studies conducted at a more aggregate level. Moreover, foreign takeovers of Swedish firms tend to have no or even a negative effect on wages.
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| 8. |
- Heyman, Fredrik, et al.
(author)
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Acquisitions, Multinationals, and Wage Dispersion
- 2006
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Other publication (other academic/artistic)abstract
- Multinational firms pay relatively high wages. Less is known about the wage structure within multinational and non-multinational firms. We examine the impact of acquisitions on wage dispersion in Sweden using a large matched employer-employee data set. Foreign acquisitions of Swedish firms increase wage dispersion by increasing wages for high-skilled workers. The positive impact is concentrated to CEOs and managers, whereas other groups are either negatively affected or not affected at all. The impact on high-skilled workers’ wages seems to be caused by the acquisition rather than the ownership itself, since ownership changes from foreign to Swedish result in similar increases.
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| 9. |
- Heyman, Fredrik, et al.
(author)
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Is there really a foreign ownership wage premium? : Evidence from matched employer-employee data
- 2007
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In: Journal of International Economics. - Elseiver : Elsevier. - 0022-1996 .- 1873-0353. ; 73:2, s. 355-376
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Journal article (peer-reviewed)abstract
- Numerous studies on firm-level data have reported higher average wages in foreign-owned firms than in domestically owned firms. This, however, does not necessarily imply that the individual worker's wage increase with foreign ownership. Using detailed matched employer–employee data on the entire Swedish private sector, we examine the effect of foreign ownership on individual wages, controlling for individual and firm heterogeneity as well as for possible selection bias in foreign acquisitions. We distinguish between foreign greenfields and takeovers and compare foreign-owned firms with both domestic multinationals and local firms. Our results show a considerably smaller wage premium in foreign-owned firms than what has been found in studies conducted at a more aggregate level. Moreover, foreign takeovers of Swedish firms tend to have no or even a negative effect on wages.
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| 10. |
- Heyman, Fredrik, et al.
(author)
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Multinationals, cross-border acquisitions and wage dispersion
- 2011
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In: Canadian Journal of Economics. - : Wiley. - 0008-4085 .- 1540-5982. ; 44:2, s. 627-650
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Journal article (peer-reviewed)abstract
- Multinational firms pay relatively high wages. Less is known about the wage structure within multinational and non-multinational firms. We examine the impact of acquisitions on wage dispersion in Sweden using a large matched employer-employee data set including about 50 percent of the Swedish labor force and with detailed information on job-tasks and education. Foreign acquisitions of both domestic multinationals and local firms increase the wage dispersion by increasing wages for high-skilled employees. The positive impact is concentrated to CEOs and other managers, whereas other groups are either negatively affected or not affected at all. The impact on high-skilled workers' wages seems to be caused by the acquisition rather than by the ownership itself, since changes from foreign to Swedish ownership result in similar increases. Our results are in line with theories stressing ownership changes as opportunities to renegotiate contracts and perform organizational changes.
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