| 1. |
- Anving, Terese, et al.
(författare)
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Informationskompetens – generella färdigheter för fördjupat lärande
- 2012
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Ingår i: Proceedings, Lunds universitets utvecklingskonferens 11. - 9789197797467 ; , s. 107-116
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Konferensbidrag (refereegranskat)abstract
- Förmågan att effektivt utnyttja och kritiskt förhålla sig till olika informationsresurser – ”information literacy” eller informationskompetens – är en central färdighet i det moderna samhället. Det utgör också en allt viktigare del av lärandet i högre utbildning. Syftet med detta paper är tvåfaldigt: 1) att problematisera relationen mellan informationskompetens som en generell färdighet och mer specifika ämnesorienterade kunskaper och färdigheter; 2) ge exempel på och utveckla redskap för lärare att på ett ämnesmässigt integrerat sätt arbeta med, utveckla och examinera studenternas informationskompetens. Ett huvudspår i framställningen är att synliggöra hur träningen i informationskompetens kan stimulera och hjälpa studenterna till fördjupade ämneskunskaper.
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| 2. |
- Beckman, Linda, Docent, 1980-, et al.
(författare)
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Coping strategies for increased wellbeing and mental health among older adults during the COVID-19 pandemic - a Swedish qualitative study
- 2023
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Ingår i: Ageing & Society. - : Cambridge University Press. - 0144-686X .- 1469-1779.
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Tidskriftsartikel (refereegranskat)abstract
- Older adults were particularly vulnerable to the COVID-19 pandemic, necessitating significant efforts to avoid contamination. This extraordinary situation posed an increased risk of mental pressure, and the ability to handle stressful situations is affected by several aspects. Therefore, this study aims to explore the coping strategies employed by older adults during the early months of the COVID-19 pandemic. A sample of 41 Swedish older adults aged 70-85 participated in phone interviews regarding their experiences with social distancing due to COVID-19. The interviews were conducted between April and May 2020, with nine follow-up interviews conducted in November and December 2020. The findings revealed results that despite the challenging circumstances, the participants demonstrated a strong mindset and resilience. Strategies utilised to improve their wellbeing and manage the situation included following recommendations, accepting the situation and maintaining a positive outlook. The influence of previous experiences on their coping strategies was evident. Additionally, the participants expressed a longing for their relatives and a need to adopt new technologies to manage their everyday lives. The follow-up interviews indicated no significant changes in worry or behaviour; if anything, participants were less worried at the beginning of the pandemic. This study contributes to the ongoing discussion on vulnerability among older adults by highlighting the diverse range of coping strategies employed during a prolonged crisis such as the COVID-19 pandemic. It demonstrated that though they are medically vulnerable, they are situationally resilient and, in many ways, well set to handle a challenging situation. During crises, older adults might need practical assistance. On the other hand, they can be a resource regarding mental preparedness during crises. Further research should explore the possibilities of balancing the needs of older adults and, at the same time, viewing them as a resource during long-time crises.
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| 3. |
- Elovaara, Pirjo, et al.
(författare)
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Gender Budgeting, Human Resources, Organisational Culture -Development of Methods
- 2015
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Annan publikation (refereegranskat)abstract
- GENISLAB, is a four year project (2011 - 2014) within the 7th Framework Programme for research and technology. The aim of the project is to promote organizational change in six European scientific organizations. Each partner develops its own Tailored Action Plan based on three dimensions, Gender Budgeting, Human Resources (HR) Management and Gender and Organisational Culture and Stereotypes. This report presents results of quantitative and qualitative data on Gender Budgeting and HR management as well as comments on organizational culture.
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| 4. |
- Gad, Helge, et al.
(författare)
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
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| 5. |
- Godoy, Patricio, et al.
(författare)
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
- 2013
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Ingår i: Archives of Toxicology. - : Springer Science and Business Media LLC. - 0340-5761 .- 1432-0738. ; 87:8, s. 1315-1530
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Forskningsöversikt (refereegranskat)abstract
- This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, as well as hepatic metabolism, is controlled by a set of nuclear receptors (including PXR, CAR, HNF-4 alpha, FXR, LXR, SHP, VDR and PPAR) and signaling pathways. When isolating liver cells, some pathways are activated, e.g., the RAS/MEK/ERK pathway, whereas others are silenced (e.g. HNF-4 alpha), resulting in up- and downregulation of hundreds of genes. An understanding of these changes is crucial for a correct interpretation of in vitro data. The possibilities and limitations of the most useful liver in vitro systems are summarized, including three-dimensional culture techniques, co-cultures with non-parenchymal cells, hepatospheres, precision cut liver slices and the isolated perfused liver. Also discussed is how closely hepatoma, stem cell and iPS cell-derived hepatocyte-like-cells resemble real hepatocytes. Finally, a summary is given of the state of the art of liver in vitro and mathematical modeling systems that are currently used in the pharmaceutical industry with an emphasis on drug metabolism, prediction of clearance, drug interaction, transporter studies and hepatotoxicity. One key message is that despite our enthusiasm for in vitro systems, we must never lose sight of the in vivo situation. Although hepatocytes have been isolated for decades, the hunt for relevant alternative systems has only just begun.
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| 6. |
- Gustavsson, Johanna, 1972-, et al.
(författare)
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Compliance to Recommendations and Mental Health Consequences among Elderly in Sweden during the Initial Phase of the COVID-19 Pandemic : A Cross Sectional Online Survey
- 2020
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 17:15, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- Background (1): In the wake of COVID-19, elderly people have been labelled a risk group.As the pandemic is a new crisis in Sweden, we have no knowledge on how this group perceives theinformation and recommendations being provided. Complying with these recommendations entailsphysical distancing and, for some, isolation at home. Methods (2): From 16 April to 15 May 2020, weconducted an online survey targeting people aged 70 and older in Sweden (n = 1854). Results (3):A vast majority of the participants find the information and recommendations clear and reliable.Half of the participants report staying at home all the time, and up to half report decreased mentalhealth in terms of, e.g., feeling depressed, having sleeping problems and that isolation makes them feelbad. However, elderly people are not a homogenous group, and there are gender and demographicdierences. (4) Conclusion: At this point, we do not know the full extent of the ongoing pandemic,either in terms of duration or in terms of losses. The Swedish model for action on COVID-19 has notincluded a lock down. However, elderly people seem to comply with recommendations and practicesocial distancing to a high degree. This might lead to decreased mental health and long-term eects.
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| 7. |
- Gustavsson, John, et al.
(författare)
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Rare earth metal salts as potential alternatives to Cr(VI) in the chlorate process
- 2010
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Ingår i: Journal of Applied Electrochemistry. - : Springer Science and Business Media LLC. - 0021-891X .- 1572-8838. ; 40:8, s. 1529-1536
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Tidskriftsartikel (refereegranskat)abstract
- Chromate is today added to industrial chlorate electrolyte, where it forms a thin cathode film of chromium hydroxide that hinders unwanted reduction of hypochlorite and chlorate. The aim of this study was to investigate rare earth metal (REM) ions as an environmentally friendly alternative to the toxic chromate addition. Potential sweeps and iR-corrected polarisation curves were recorded using rotating disc electrodes of iron and gold. Addition of Y(III), La(III) or Sm(III) to 5 M NaCl at 70 A degrees C suppressed hypochlorite reduction. Activation of hydrogen evolution by REM ion addition to 0.5 M NaCl was more significant at 25 A degrees C than at 50 and 70 A degrees C. Increasing the chloride concentration to 5 M had a detrimental effect on this activation. The major problem in replacing chromate with REM salts is the poor solubility of REM ions at normal chlorate process conditions, and therefore REM salts are not a realistic alternative to chromate addition.
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| 8. |
- Gustavsson, Johanna, 1972-, et al.
(författare)
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Understanding factors for adhering to health recommendations during COVID-19 among older adults - a qualitative interview study using health belief model as analytical framework
- 2024
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Ingår i: BMC Geriatrics. - : BioMed Central (BMC). - 1471-2318. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: The COVID-19 pandemic has presented a unique possibility to broaden the understanding of people’s reactions to a global crisis. Early on, it became evident that older adults were particularly vulnerable to the virus and that the actions of this age group would be crucial to the outcome. This qualitative interview study uses the Health Belief Model (HBM) framework as an analytical tool to examine older people’s experiences of adherence to recommendations during the initial phase of the COVID-19 pandemic. It is important to view this study in the context of Sweden’s voluntary restrictions, which further highlight the unique nature of this research. Method: In April-May 2020, 41 adults aged 70–85 participated in unstructured phone interviews. The objective was to investigate older adults’ perceptions of the COVID-19 pandemic, particularly their understanding of the disease and the conditions that influenced their adherence to health recommendations. HBM was used as an analytical framework to guide the analysis of the interviews. Results: Despite perceiving COVID-19 as a severe threat to health and society, participants did not let fear dominate their responses. Instead, they demonstrated remarkable resilience and a proactive approach. For some, the perceived susceptibility to the disease was the primary motivator for adherence to the Swedish national recommendations. Notably, trust in the authorities and family members’ requests significantly bolstered adherence. Moreover, adherence was found to contribute to feelings of safety. Conversely, potential barriers to adhering to recommendations included missing loved ones and frustration with sometimes ambiguous information from authorities. Conclusions: The results from this study indicate that older adults are willing to adhere to voluntary restrictions during a global pandemic. Relatives of older people are a resource for communicating information regarding safety and health messages, a message that is preferably thorough and consistent. Further, much can be gained if loneliness during isolation can be mitigated since missing loved ones appears to be a potential barrier to adherence.
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| 9. |
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| 10. |
- Gustavsson, Linda, 1976-, et al.
(författare)
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An impact analysis of regional industry–university interactions:the case of industrial PhD schools
- 2016
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Ingår i: Industry and Higher Education. - : Sage Publications. - 0950-4222 .- 2043-6858. ; 30:1, s. 41-51
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Tidskriftsartikel (refereegranskat)abstract
- The authors discuss Triple Helix collaborations in the context of regional competitiveness. Through an exploratory case study, they identify and analyse the impact of the establishment of industrial PhD schools for participating industry and universities. The study was conducted in Sweden in 2014 and focuses on three industry–university initiatives involving a total of 57 doctoral students, 9 universities and 39 companies. The results indicate that PhD schools based on the dynamics of the Triple Helix can be of great benefit for both industry and regional universities. In addition, the paper identifies critical success factors for industry–university collaborations involving joint PhD education.
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