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- Gendreau, R. Michael, et al.
(author)
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Self-guided digital behavioural therapy versus active control for fibromyalgia (PROSPER-FM) : a phase 3, multicentre, randomised controlled trial
- 2024
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In: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 404:10450, s. 364-374
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Journal article (peer-reviewed)abstract
- Background International guidelines have recommended cognitive behavioural therapy, including acceptance and commitment therapy (ACT), as it offers validated benefits for managing fibromyalgia; however, it is inaccessible to most patients. We aimed to evaluate the effect of a 12-week, self-guided, smartphone-delivered digital ACT programme on fibromyalgia management. Methods In the PROSPER-FM randomised clinical trial conducted at 25 US community sites, adult participants aged 22-75 years with fibromyalgia were recruited and randomly assigned (1:1) to the digital ACT group or an active control group that offered daily symptom tracking and monitoring and access to health-related and fibromyalgiarelated educational materials. Randomisation was done with a web-based system in permuted blocks of four at the site level. We used a blind-to-hypothesis approach in which participants were informed they would be randomly assigned to one of two potentially effective therapies under evaluation. Research staff were not masked to group allocation, with the exception of a masked statistics group while preparing statistical programming for the interim analysis. The primary endpoint was patient global impression of change (PGIC) response rate at week 12. Analyses were by intention to treat. The trial was registered with ClinicalTrials.gov, NCT05243511 (now fully closed). Findings Between Feb 8, 2022, and Feb 2, 2023, 590 individuals were screened, of whom 275 (257 women and 18 men) were randomly assigned to the digital ACT group (n=140) and the active control group (n=135). At 12 weeks, 99 (71%) of 140 ACT participants reported improvement on PGIC versus 30 (22%) of 135 active control participants, corresponding to a difference in proportions of 484% (95% CI 379-589; p<00001). No device-related safety events were reported. Interpretation Digital ACT was safe and efficacious compared with digital symptom tracking in managing fibromyalgia in adult patients. Copyright (c) 2024 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies.
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- Guthrie, J, et al.
(author)
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Sunrise in the knowledge economy: managing, measuring, and reporting intellectual capital
- 2001
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In: Accounting, Auditing & Accountability Journal. - : Emerald. - 1368-0668 .- 1758-4205. ; 14:4, s. 365-382
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Journal article (peer-reviewed)abstract
- The two aims of this paper are: 1. to draw attention to the gaps in the research literature, and 2. to stimulate further accounting and management research regarding intellectual capital by posing several possible research questions. It is suggested that critical and social accounting academics have a vital role to play in making visible a number of important social issues that stem from understanding better the value of intellectual capital within both organizations and the wider social fabric. The paper also examines possible new ways of accounting for intangibles within public and private sector organizations.
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- Guthrie, M., et al.
(author)
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Thermal expansion in UO2 determined by high-energy X-ray diffraction
- 2016
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In: Journal of Nuclear Materials. - : Elsevier BV. - 0022-3115. ; 479, s. 19-22
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Journal article (peer-reviewed)abstract
- Here we present crystallographic analyses of high-energy X-ray diffraction data on polycrystalline UO2 up to the melting temperature. The Rietveld refinements of our X-ray data are in agreement with previous measurements, but are systematically located around the upper bound of their uncertainty, indicating a slightly steeper trend of thermal expansion compared to established values. This observation is consistent with recent first principles calculations.
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