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Träfflista för sökning "WFRF:(Hübner H) "

Search: WFRF:(Hübner H)

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  • Rajewsky, N., et al. (author)
  • LifeTime and improving European healthcare through cell-based interceptive medicine
  • 2020
  • In: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 587:7834, s. 377-386
  • Journal article (peer-reviewed)abstract
    • LifeTime aims to track, understand and target human cells during the onset and progression of complex diseases and their response to therapy at single-cell resolution. This mission will be implemented through the development and integration of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during progression from health to disease. Analysis of such large molecular and clinical datasets will discover molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. Timely detection and interception of disease embedded in an ethical and patient-centered vision will be achieved through interactions across academia, hospitals, patient-associations, health data management systems and industry. Applying this strategy to key medical challenges in cancer, neurological, infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.
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  • Sungnak, W., et al. (author)
  • SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
  • 2020
  • In: Nature Medicine. - : Nature Research. - 1078-8956 .- 1546-170X. ; 26:5, s. 681-687
  • Journal article (peer-reviewed)abstract
    • We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org. 
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  • Result 1-10 of 78
Type of publication
journal article (51)
conference paper (16)
book chapter (6)
research review (2)
reports (1)
doctoral thesis (1)
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licentiate thesis (1)
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Type of content
peer-reviewed (71)
other academic/artistic (7)
Author/Editor
Hübner, A. (17)
Kratz, J. V. (16)
Khuyagbaatar, J. (16)
Krier, J. (16)
Schausten, B. (16)
Yakushev, A. (16)
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Lommel, B. (16)
Kindler, B. (16)
Jäger, E. (16)
Kurz, N (15)
Herzberg, R-D (15)
Runke, J. (15)
Schädel, M. (15)
Uusitalo, J. (14)
Even, J. (14)
Block, M (14)
Wegrzecki, M. (14)
Hubner, N. (13)
Hoffmann, J (13)
Ackermann, D. (13)
Steiner, J. (13)
Lahiri, S (12)
Eberhardt, K. (12)
Heßberger, F. P. (12)
Maiti, M. (12)
Thörle-Pospiech, P. (12)
Rudolph, Dirk (11)
Brand, H (11)
Di Nitto, A. (11)
Omtvedt, J. P. (11)
Hartmann, W (10)
Cox, D. M. (10)
Fischer-Hübner, Simo ... (10)
Andersson, L-L (10)
Nitsche, H. (10)
Düllmann, Ch.E. (10)
Trautmann, N. (10)
Semchenkov, A. (9)
Minami, S (9)
Gates, J.M. (9)
Papadakis, P. (8)
Gregorich, K.E. (8)
Asai, M. (7)
Martucci, Leonardo, ... (7)
Fischer-Hübner, Simo ... (7)
Lee, YA (7)
Renisch, D. (7)
Forsberg, Ulrika (7)
Mokry, C. (7)
Hollinger, R. (7)
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University
Karolinska Institutet (32)
Lund University (21)
Karlstad University (18)
Linköping University (6)
University of Gothenburg (4)
Umeå University (3)
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Uppsala University (3)
Örebro University (3)
University of Skövde (3)
Royal Institute of Technology (2)
Stockholm University (2)
Chalmers University of Technology (2)
Swedish University of Agricultural Sciences (1)
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Language
English (78)
Research subject (UKÄ/SCB)
Natural sciences (41)
Medical and Health Sciences (21)
Engineering and Technology (2)
Social Sciences (1)

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