| 1. |
- Majidi, Fatemeh, et al.
(författare)
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Clinical spectrum of primary adrenal lymphoma: results of a multicenter cohort study
- 2020
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Ingår i: European Journal of Endocrinology. - : BIOSCIENTIFICA LTD. - 0804-4643 .- 1479-683X. ; 183:4, s. 453-462
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: We sought to refine the clinical picture of primary adrenal lymphoma (PAL), a rare lymphoid malignancy with predominant adrenal manifestation and risk of adrenal insufficiency. Methods: Ninety-seven patients from 14 centers in Europe, Canada and the United States were included in this retrospective analysis between 1994 and 2017. Results: Of the 81 patients with imaging data, 19 (23%) had isolated adrenal involvement (iPAL), while 62 (77%) had additional extra-adrenal involvement (PAL+). Among patients who had both CT and PET scans, 18FDG-PET revealed extra-adrenal involvement not detected by CT scan in 9/18 cases (50%). The most common clinical manifestations were B symptoms (55%), fatigue (45%), and abdominal pain (35%). Endocrinological assessment was often inadequate. With a median follow-up of 41.6 months, 3-year progression-free (PFS) and overall (OS) survival rates in the entire cohort were 35.5% and 39.4%, respectively. The hazard ratios of iPAL for PFS and OS were 40.1 (95% CI: 2.63-613.7, P = 0.008) and 2.69 (95% CI: 0.61-11.89, P = 0.191), respectively. PFS was much shorter in iPAL vs PAL+ (median 4 months vs not reached, P = 0.006), and OS also appeared to be shorter (median 16 months vs not reached), but the difference did not reach statistical significance (P = 0.16). Isolated PAL was more frequent in females (OR = 3.81; P = 0.01) and less frequently associated with B symptoms (OR = 0.159; P = 0.004). Conclusion: We found unexpected heterogeneity in the clinical spectrum of PAL. Further studies are needed to clarify whether clinical distinction between iPAL and PAL+ is corroborated by differences in molecular biology.
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| 2. |
- Beck, Matthias, et al.
(författare)
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Smooth Centrally Symmetric Polytopes in Dimension 3 are IDP
- 2019
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Ingår i: Annals of Combinatorics. - : Springer Publishing Company. - 0218-0006 .- 0219-3094. ; 23:2, s. 255-262
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Tidskriftsartikel (refereegranskat)abstract
- In 1997 Oda conjectured that every smooth lattice polytope has the integer decomposition property. We prove Oda's conjecture for centrally symmetric 3-dimensional polytopes, by showing they are covered by lattice parallelepipeds and unimodular simplices.
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| 3. |
- Hauge, Jannicke, et al.
(författare)
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ANALYSIS ON EDUCATING MECHANICAL ENGINEERS THROUGH SERIOUS GAMES USING PERVASIVE TECHNOLOGIES
- 2016
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Ingår i: PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES AND COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE, 2016, VOL 1B. - : AMER SOC MECHANICAL ENGINEERS.
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Konferensbidrag (refereegranskat)abstract
- In the education of mechanical engineers alternative learning methods like serious games, simulations etc. have been used in past decades to better the learning outcomes. However, as digital technologies advance, so too does the quality of commercial game-based learning. This brings the expectation that while serious games are still considered as an experimental pedagogic vehicle, the learning experience among students and their experience of using serious games become heightened. This is a challenge for several educational games that though fully able to progress a learning goal, is deemed detached due to its dated user interface and inability to host the latest ICTs. This creates an unappealing aspect to the student and can also affect their motivation. This paper reports on the early efforts to analyze serious games from the perspective of learning and gaming mechanics and the virtual environment and systems that can be made pervasive. The intention is to re-furbish dated serious games that are highly relevant to. educating mechanical engineers. The proposed concepts lie in the adoption of new pervasive technologies enabled by cyber-physical systems (CPS) and Internet of things (IoT) to modernize dated engineering serious games.
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| 4. |
- Saldan, Ivan, et al.
(författare)
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Hydrogen Sorption in the LiH-LiF-MgB2 System
- 2013
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Ingår i: Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 117:33, s. 17360-17366
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Tidskriftsartikel (refereegranskat)abstract
- A composite material in the LiH-LiF-MgB2 system has been synthesized by high-energy ball milling. Some peaks in addition to that of the binary 2LiH-MgB2 and 2LiF-MgB2 systems are observed for the composite material by high-pressure differential scanning calorimetry (HP-DSC), indicating the formation of intermediate phases. In situ synchrotron radiation powder X-ray diffraction (SR-PXD) performed at 60 bar of H-2 and 390 degrees C shows a superposition of both reaction pathways that are typical for 2LiH-MgB2 and 2LiF-MgB2. After hydrogen absorption of the LiH-LiF-MgB2 composite the vibrational modes of LiBH4 were observed by attenuated total reflection infrared (ATR-IR) spectroscopy. The F-19 MAS NMR spectrum of the LiF-LiBH4 sample after heat treatment in hydrogen is strongly dominated by the centerband and spinning sidebands from LiF; in addition, a low-intensity resonance, very similar to that of [BF4](-) ion, is identified.
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| 5. |
- Schwarz, Maria, et al.
(författare)
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Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P.
- 2023
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Ingår i: Nature communications. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P (SELENOP) and SELENOP-mediated transport from the liver to e.g. the brain. In addition, the liver maintains copper homeostasis. Selenium and copper metabolism are inversely regulated, as increasing copper and decreasing selenium levels are observed in blood during aging and inflammation. Here we show that copper treatment increased intracellular selenium and SELENOP in hepatocytes and decreased extracellular SELENOP levels. Hepatic accumulation of copper is a characteristic of Wilson's disease. Accordingly, SELENOP levels were low in serum of Wilson's disease patients and Wilson's rats. Mechanistically, drugs targeting protein transport in the Golgi complex mimicked some of the effects observed, indicating a disrupting effect of excessive copper on intracellular SELENOP transport resulting in its accumulation in the late Golgi. Our data suggest that hepatic copper levels determine SELENOP release from the liver and may affect selenium transport to peripheral organs such as the brain.
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