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Search: WFRF:(Handy RD)

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  • Serra, A, et al. (author)
  • INSIdE NANO: a systems biology framework to contextualize the mechanism-of-action of engineered nanomaterials
  • 2019
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 179-
  • Journal article (peer-reviewed)abstract
    • Engineered nanomaterials (ENMs) are widely present in our daily lives. Despite the efforts to characterize their mechanism of action in multiple species, their possible implications in human pathologies are still not fully understood. Here we performed an integrated analysis of the effects of ENMs on human health by contextualizing their transcriptional mechanism-of-action with respect to drugs, chemicals and diseases. We built a network of interactions of over 3,000 biological entities and developed a novel computational tool, INSIdE NANO, to infer new knowledge about ENM behavior. We highlight striking association of metal and metal-oxide nanoparticles and major neurodegenerative disorders. Our novel strategy opens possibilities to achieve fast and accurate read-across evaluation of ENMs and other chemicals based on their biosignatures.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (3)
Author/Editor
Greco, D (3)
Handy, RD (3)
Fortino, V (2)
Karisola, P (2)
Alenius, H (2)
Kinaret, PAS (2)
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Wolff, H (2)
Fadeel, B (2)
Savolainen, K (2)
Ndika, J (2)
Ilves, M (2)
Kere, J (1)
Serra, A (1)
Skoog, T (1)
Norppa, H (1)
Loeschner, K. (1)
Letunic, I. (1)
Correia, M. (1)
Vales, G (1)
Moya, S (1)
Marwah, V (1)
Fedutik, Y (1)
Ehrlich, N (1)
Besinis, A (1)
Vassallo, J (1)
Tagliaferri, R (1)
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University
Karolinska Institutet (3)
Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)

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