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- Hansson, Kristofer, et al.
(author)
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Introduction: Interpreting the brain in society
- 2017
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In: Interpreting the brain in society. Cultural reflections on neuroscientific practices. - 1404-000X. - 9789179242930 - 9789198085495 - 9789179242961 ; , s. 11-15
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Book chapter (peer-reviewed)
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| 2. |
- Bergström, Markus, et al.
(author)
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The Settlement
- 2019
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In: Verksmidjan art space in Hjalteyri, Iceland (Permanent installation) N4 regional television.
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Artistic work (other academic/artistic)abstract
- A one week workshop and performance leading up to a permanent installation of a prototyped, functional living space within a former fish factory. Initiated by french artist Sonia Levy, director of Verksmidjan Gustav Geir Bollason and myself. Carried out in all by 13 participants (stated above).
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| 7. |
- Lindgren, Markus, 1975-
(author)
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Measurement and Simulation Based Techniques for Real-Time Systems Analysis
- 2000
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Licentiate thesis (other academic/artistic)abstract
- Rigorous methods for design and implementation of safety critical real-time systems are vital to avoid loss of human lives and/or severe economic losses. Unfortunately, many of these systems are designed and evaluated using ad-hoc techniques. There are, on the other hand, relatively well developed theories for modeling and analysis of timing and reliability. These theories are, however, seldom applied in industry for system development, mainly because of the simplifying model assumptions and lack of appropriate tool support.This thesis presents two new methods aimed to narrow the gap between research results and industrial practice in evaluation and design of real-time systems.The first contribution is a technique that can be used to derive worst-case execution time estimates for real-time software by measurments on the target system. Such estimates are essential when verifying if a system fulfills its timing requirements. The second contribution is a simulation based technique that can be used to evaluate timing aspects of distributed real-time systems, as well as calculating reliability estimates of these systems. Such estimates are essential in determining if a system meets its requirements sufficiently well. Compared to existing analytical methods for execution time analysis and schedulability analysis, which analyze models of the hardware, the starting point for both these methods are real target systems, rather than an abstract model with limited correspondance to reality.The presented initial case-studies give clear evidence that the proposed methods have potential of being both applicable and useful.
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| 8. |
- Mitchell, Jonathan S., et al.
(author)
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Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
- 2016
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Journal article (peer-reviewed)abstract
- Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P = 1.31 x 10(-8)), 6q21 (rs9372120, P = 9.09 x 10(-15)), 7q36.1 (rs7781265, P = 9.71 x 10(-9)), 8q24.21 (rs1948915, P = 4.20 x 10(-11)), 9p21.3 (rs2811710, P = 1.72 x 10(-13)), 10p12.1 (rs2790457, P = 1.77 x 10(-8)), 16q23.1 (rs7193541, P = 5.00 x 10(-12)) and 20q13.13 (rs6066835, P = 1.36 x 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.
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| 9. |
- Schmidt, Amand F., et al.
(author)
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Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
- 2019
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In: BMC Cardiovascular Disorders. - : BMC. - 1471-2261 .- 1471-2261. ; 19:1
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Journal article (peer-reviewed)abstract
- Background: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. Results: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer's disease - outcomes for which large-scale trial data were unavailable. Conclusions: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate.
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| 10. |
- Went, Molly, et al.
(author)
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Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology
- 2018
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In: Blood Cancer Journal. - : Springer Science and Business Media LLC. - 2044-5385. ; 9:1
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Journal article (peer-reviewed)abstract
- The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between these two B-cell malignancies was shown (Rg = 0.4, P = 0.0046). Furthermore, four of the 45 known CLL risk loci were shown to associate with MM risk and five of the 23 known MM risk loci associate with CLL risk. By integrating eQTL, Hi-C and ChIP-seq data, we show that these pleiotropic risk loci are enriched for B-cell regulatory elements and implicate B-cell developmental genes. These data identify shared biological pathways influencing the development of CLL and, MM and further our understanding of the aetiological basis of these B-cell malignancies.
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