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Search: WFRF:(Harri Jerome)

  • Result 1-4 of 4
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1.
  • Amadeo, Marica, et al. (author)
  • Enhancing the 3GPP V2X Architecture with Information-Centric Networking
  • 2019
  • In: Future Internet. - Basel : MDPI. - 1999-5903. ; 11:9
  • Journal article (peer-reviewed)abstract
    • Vehicle-to-everything (V2X) communications allow a vehicle to interact with other vehicles and with communication parties in its vicinity (e.g., road-side units, pedestrian users, etc.) with the primary goal of making the driving and traveling experience safer, smarter and more comfortable. A wide set of V2X-tailored specifications have been identified by the Third Generation Partnership Project (3GPP) with focus on the design of architecture enhancements and a flexible air interface to ensure ultra-low latency, highly reliable and high-throughput connectivity as the ultimate aim. This paper discusses the potential of leveraging Information-Centric Networking (ICN) principles in the 3GPP architecture for V2X communications. We consider Named Data Networking (NDN) as reference ICN architecture and elaborate on the specific design aspects, required changes and enhancements in the 3GPP V2X architecture to enable NDN-based data exchange as an alternative/complementary solution to traditional IP networking, which barely matches the dynamics of vehicular environments. Results are provided to showcase the performance improvements of the NDN-based proposal in disseminating content requests over the cellular network against a traditional networking solution. © 2019 by the authors.
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2.
  • Aramrattana, Maytheewat, 1988-, et al. (author)
  • Evaluating Model Mismatch Impacting CACC Controllers in Mixed Traffic using a Driving Simulator
  • 2018
  • In: 2018 IEEE Intelligent Vehicles Symposium (IV). - New York, NY : IEEE. - 9781538644522 - 9781538644515 - 9781538644539 ; , s. 1867-1872
  • Conference paper (peer-reviewed)abstract
    • At early market penetration, automated vehicles will share the road with legacy vehicles. For a safe transportation system, automated vehicle controllers therefore need to estimate the behavior of the legacy vehicles. However, mismatches between the estimated and real human behaviors can lead to inefficient control inputs, and even collisions in the worst case. In this paper, we propose a framework for evaluating the impact of model mismatch by interfacing a controller under test with a driving simulator. As a proof-of-concept, an algorithm based on Model Predictive Control (MPC) is evaluated in a braking scenario. We show how model mismatch between estimated and real human behavior can lead to a decrease in avoided collisions by almost 46%, and an increase in discomfort by almost 91%. Model mismatch is therefore non-negligible and the proposed framework is a unique method to evaluate them. © 2018 IEEE.
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3.
  • Joshi, Peter K, et al. (author)
  • Directional dominance on stature and cognition in diverse human populations
  • 2015
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 523:7561, s. 459-462
  • Journal article (peer-reviewed)abstract
    • Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10(-300), 2.1 × 10(-6), 2.5 × 10(-10) and 1.8 × 10(-10), respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.
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4.
  • Kanoni, Stavroula, et al. (author)
  • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
  • 2022
  • In: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1
  • Journal article (peer-reviewed)abstract
    • Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
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  • Result 1-4 of 4
Type of publication
journal article (3)
conference paper (1)
Type of content
peer-reviewed (4)
Author/Editor
Salomaa, Veikko (2)
Lind, Lars (2)
Sattar, Naveed (2)
Campbell, Harry (2)
Strachan, David P (2)
Deloukas, Panos (2)
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North, Kari E. (2)
Wareham, Nicholas J. (2)
Kraft, Peter (2)
Kuusisto, Johanna (2)
Laakso, Markku (2)
Ridker, Paul M. (2)
Chasman, Daniel I. (2)
Ikram, M. Arfan (2)
van Duijn, Cornelia ... (2)
Magnusson, Patrik K ... (2)
Boehnke, Michael (2)
Mohlke, Karen L (2)
Zhao, Wei (2)
Kähönen, Mika (2)
Lehtimäki, Terho (2)
Verweij, Niek (2)
Rotter, Jerome I. (2)
Mangino, Massimo (2)
Gieger, Christian (2)
Martin, Nicholas G. (2)
Boomsma, Dorret I. (2)
Spector, Tim D. (2)
Kaprio, Jaakko (2)
Samani, Nilesh J. (2)
Caulfield, Mark J. (2)
Munroe, Patricia B. (2)
Palmer, Colin N. A. (2)
Harri, Jerome (2)
Wilson, James F. (2)
Schmidt, Reinhold (2)
Schmidt, Helena (2)
Hakonarson, Hakon (2)
Jousilahti, Pekka (2)
Zhao, Jing Hua (2)
Homuth, Georg (2)
Launer, Lenore J (2)
Loos, Ruth J F (2)
Psaty, Bruce M (2)
Vitart, Veronique (2)
Hayward, Caroline (2)
Gudnason, Vilmundur (2)
Hirschhorn, Joel N. (2)
Campbell, Archie (2)
Zeggini, Eleftheria (2)
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University
Uppsala University (2)
Halmstad University (2)
Karolinska Institutet (2)
University of Gothenburg (1)
Lund University (1)
Stockholm School of Economics (1)
Language
English (4)
Research subject (UKÄ/SCB)
Engineering and Technology (2)
Natural sciences (1)
Medical and Health Sciences (1)

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