| 1. |
- Bødker, Anders, et al.
(author)
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Estrogen receptors in the human male bladder, prostatic urethra, and prostate. An immunohistochemical and biochemical study
- 1995
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In: Scandinavian Journal of Urology and Nephrology. - : Informa UK Limited. - 0036-5599 .- 1651-2065. ; 29:2, s. 161-165
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Journal article (peer-reviewed)abstract
- The distribution and quantity of estrogen receptors (ERs) in the human male bladder, prostatic urethra and the prostate were studied in eight males with recurrent papillomas of the bladder or monosymptomatic hematuria (median age 61 years), 14 men undergoing transurethral resection due to benign prostatic hyperplasia (median age 70 years), and nine men undergoing cystectomy due to malignant tumour of the bladder (median age 70 years). In the first group of patients, biopsies for immunohistochemical examination were obtained from the bladder vault, bottom, both side-walls, the trigone area, and the mid-portion of the prostatic urethra, and in the second group from three locations of the prostatic urethra (bladder neck, mid-portion and veramontanum). In the third group, tissue specimens were taken from the vault of the bladder, prostatic urethra, and the prostate, for immunohistochemical as well as biochemical analysis. In the first group, ERs were found in three out of eight specimens of the prostatic urethra, and in one of these, ERs were confined to periurethral glands. ERs could not be demonstrated in any of the bladder-biopsies. In the second group, ERs were not found in the bladder neck, but were seen in four preparations from the veramontanum and in two from the midportion of the urethra. ERs were located in the urothelium and periurethral glands. In the third group, ERs were seen immunohistochemically in the prostatic urethra (two cases) and the prostatic stromal tissue (two cases). ERs could be demonstrated in the bladder neither by immunohistochemistry nor biochemically.(ABSTRACT TRUNCATED AT 250 WORDS)
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| 2. |
- Carlsson, Hans-Erik, et al.
(author)
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Purification, characterization, and biological compartmentalization of rat fetal antigen 1
- 2000
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In: Biology of Reproduction. - : Society for the Study of Reproduction. - 0006-3363 .- 1529-7268. ; 63:1, s. 30-33
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Journal article (peer-reviewed)abstract
- This study has established the rat as an animal model for the analysis of the biological role of fetal antigen 1 (FA1), a protein previously described in humans and mice. FA1 was purified from rat amniotic fluid by immunospecific affinity chromatography. Immunochemical identity between mouse and rat FA1 was established by crossed tandem immunoelectrophoresis. Molecular size was analyzed by mass spectrometry (33 kDa). The amino acid composition was determined, and the amino acid sequence was analyzed. The overall amino acid composition and sequence of the 28 first N-terminal amino acids were identical to the corresponding parts of rat preadipocyte factor 1 and rat adrenal zone glomerulosa protein. Extensive sequence similarity was found between rat and mouse FA1 (86%) and between rat and human FA1 (82%). The concentration of FA1 in fetal serum, maternal serum, urine, and amniotic fluid in rats was determined using an ELISA. The highest concentrations were found in fetal serum and amniotic fluid around Day 18 of pregnancy. This is the first report on the physicochemical characteristics and compartmentalization of rat FA1.
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| 3. |
- Frykholm, Erik, 1985-, et al.
(author)
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Applicability of a supramaximal high-intensity interval training program for older adults previously not engaged in regular exercise : analyses of secondary outcomes from the Umeå HIT Study
- 2024
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In: Psychology of Sport And Exercise. - : Elsevier. - 1469-0292 .- 1878-5476. ; 73
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Journal article (peer-reviewed)abstract
- This analysis of secondary outcomes investigated the applicability of supramaximal high-intensity interval training (HIT) with individually prescribed external intensity performed on stationary bicycles. Sixty-eight participants with a median (min; max) age of 69 (66; 79), at the time not engaged in regular exercise were randomized to 25 twice-weekly sessions of supramaximal HIT (20-min session with 10 × 6-s intervals) or moderate-intensity training (MIT, 40-min session with 3 × 8-min intervals). The primary aim was outcomes on applicability regarding; adherence to prescribed external interval intensity, participant reported positive and negative events, ratings of perceived exertion (RPE 6–20), and affective state (Feeling Scale, FS -5–5). A secondary aim was to investigate change in exercise-related self-efficacy (Exercise Self-Efficacy Scale) and motivation (Behavioural Regulations in Exercise Questionnaire-2). Total adherence to the prescribed external interval intensity was [median (min; max)] 89 % (56; 100 %) in supramaximal HIT, and 100 % (95; 100 %) in MIT. The supramaximal HIT group reported 60 % of the positive (112 of 186) and 36 % of the negative (52 of 146) events. At the end of the training period, the median (min; max) session RPE was 15 (12; 17) for supramaximal HIT and 14 (9; 15) for MIT. As for FS, the median last within-session rating was 3 (−1; 5) for supramaximal HIT and 3 (1; 5) for MIT. Exercise-related motivation increased (mean difference in Relative Autonomy Index score = 1.54, 95 % CI [0.69; 2.40]), while self-efficacy did not change (mean difference = 0.55, 95 % CI [-0.75; 1.82]), regardless of group. This study provide support for supramaximal HIT in supervised group settings for older adults.
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| 4. |
- Hedlund, Pe rOlov, et al.
(author)
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Significance of pretreatment cardiovascular morbidity as a risk factor during treatment with parenteral oestrogen or combined androgen deprivation of 915 patients with metastasized prostate cancer: Evaluation of cardiovascular events in a randomized trial
- 2011
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In: Scandinavian Journal of Urology and Nephrology. - London : Informa Healthcare. - 0036-5599 .- 1651-2065. ; 45:5, s. 346-353
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Journal article (peer-reviewed)abstract
- Objective. This study aimed to evaluate prognostic risk factors for cardiovascular events during treatment of metastatic prostate cancer patients with high-dose parenteral polyoestradiol phosphate (PEP, Estradurin (R)) or combined androgen deprivation (CAD) with special emphasis on pretreatment cardiovascular disease. Material and methods. Nine-hundred and fifteen patients with T0-4, Nx, M1, G1-3, hormone- naive prostate cancer were randomized to treatment with PEP 240 mg i.m. twice a month for 2 months and thereafter monthly, or to flutamide (Eulexin (R)) 250 mg per os three times daily in combination with either triptorelin (Decapeptyl (R)) 3.75 mg i.m. per month or on an optional basis with bilateral orchidectomy. Pretreatment cardiovascular morbidity was recorded and cardiovascular events during treatment were assessed by an experienced cardiologist. A multivariate analysis was done using logistic regression. Results. There was a significant increase in cardiovascular events during treatment with PEP in patients with previous ischaemic heart disease (p = 0.008), ischaemic cerebral disease (p = 0.002), intermittent claudication (p = 0.031) and especially when the whole group of patients with pretreatment cardiovascular diseases was analysed together (p andlt; 0.001). In this group 33% of the patients had a cardiovascular event during PEP treatment. In the multivariate analysis PEP stood out as the most important risk factor for cardiac complications (p = 0.029). Even in the CAD group there was a significant increase in cardiovascular events in the group with all previous cardiovascular diseases taken together (p = 0.036). Conclusions. Patients with previous cardiovascular disease are at considerable risk of cardiovascular events during treatment with high-dose PEP and even during CAD therapy. Patients without pretreatment cardiovascular morbidity have a moderate cardiovascular risk during PEP treatment and could be considered for this treatment if the advantages of this therapy, e. g. avoidance of osteopenia and hot flushes and the low price, are given priority.
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| 5. |
- Akhtar, Farid, et al.
(author)
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Preparation of graded silicalite-1 substrates for all-zeolite membranes with excellent CO2/H-2 separation performance
- 2015
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In: Journal of Membrane Science. - : Elsevier BV. - 0376-7388 .- 1873-3123. ; 493, s. 206-211
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Journal article (peer-reviewed)abstract
- Graded silicalite-1 substrates with a high gas permeability and low surface roughness have been produced by pulsed current processing of a thin coating of a submicron silicalite-1 powder onto a powder body of coarser silicalite-1 crystals. Thin zeolite films have been hydrothermally grown onto the graded silicalite-1 support and the all-zeolite membranes display an excellent CO2/H-2 separation factor of 12 at 0 degrees C and a CO2 permeance of 21.3 x 10(-7) mol m(-2) s(-1) Pa-1 for an equimolar CO2/H-2 feed at 505 kPa and 101 kPa helium sweep gas. Thermal cracking estimates based on calculated surface energies and measured thermal expansion coefficients suggest that all-zeolite membranes with a minimal thermal expansion mismatch between the graded substrate and the zeolite film should remain crack-free during thermal cycling and the critical calcination step.
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| 6. |
- Akrami, Nazar, et al.
(author)
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Personality scale response latencies as self-schema indicators : The inverted-U effect revisited
- 2007
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In: Personality and Individual Differences. - : Elsevier BV. - 0191-8869 .- 1873-3549. ; 43:3, s. 611-618
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Journal article (peer-reviewed)abstract
- In two studies, we examined the relationship between participants’ responses to the items in the NEO-PI Big Five personality inventory and their response latencies to the same items. Extending previous research, we used polynomial regression analysis to examine if the relation between participants’ position on each of the Big Five factors and their average response latencies (regarded as self-schema indicators) across items on the same factors is characterised by a curvilinear (inverted-U) trend or not. The analyses in both studies yielded consistent support for a quadratic (curvilinear) relation between personality scores and response latencies for all Big Five factors. Those scoring high or low on a factor responded faster than those scoring around the mean, which lends support to the notion that the relation between personality scores and response latencies is characterised by an inverted-U effect. The results are discussed in the light of previousattempts to examining the inverted-U effect as self-schema evidence. Further, we discuss the potential of using response latency data to improve precision in personality assessment and prediction.
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| 7. |
- Al-Gburi, Majid, et al.
(author)
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Simplified methods for crack risk analyses of early age concrete : Part 1: Development of Equivalent Restraint Method
- 2012
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In: Nordic Concrete Research. - 0800-6377. ; 46:2, s. 17-38
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Journal article (peer-reviewed)abstract
- The present study deals with both the compensation plane method, CPM, and local restraint method, LRM, as alternative methods studying crack risks for early age concrete. It is shown that CPM can be used both for cooling and heating, but basic LRM cannot be applied to heating. This paper presents an improved equivalent restraint method, ERM, which easily can be applied both for usage of heating and cooling for general structures. Restraint curves are given for two different infrastructures, one founded on frictional materials and another on rock. Such curves might be directly applied in design using LRM and ERM.
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| 8. |
- Alarcon, Hugo, et al.
(author)
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Modification of nanostructured TiO2 electrodes by electrochemical Al3+ insertion : Effects on dye-sensitized solar cell performance
- 2007
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In: The Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 111:35, s. 13267-13274
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Journal article (peer-reviewed)abstract
- Nanostructured TiO2 films were modified by insertion with aluminum ions using an electrochemical process. After heat treatment these films were found suitable as electrodes in dye-sensitized solar cells. By means of a catechol adsorption test, as well as photoelectron spectroscopy (PES), it was demonstrated that the density of Ti atoms at the metal oxide/electrolyte interface is reduced after Al modification. There is, however, not a complete coverage of aluminum oxide onto the TiO2, but the results rather suggest either the formation of a mixed Al-Ti oxide surface layer or formation of a partial aluminum oxide coating. No new phase could, however, be detected. In solar cells incorporating Al-modified TiO2 electrodes, both electron lifetimes and electron transport times were increased. At high concentrations of inserted aluminum ions, the quantum efficiency for electron injection was significantly decreased. Results are discussed at the hand of different models: A multiple trapping model, which can explain slower kinetics by the creation of additional traps during Al insertion, and a surface layer model, which can explain the reduced recombination rate, as well as the reduced injection efficiency, by the formation of a blocking layer.
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| 9. |
- Albrecht, Knut, et al.
(author)
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Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human vagina: : A potential forensic value?
- 2007
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In: Journal of forensic and legal medicine. - : Elsevier BV. - 1752-928X. ; 14:5, s. 270-274
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Journal article (peer-reviewed)abstract
- Objectives Phosphodiesterase (PDE) isoenzymes are key proteins involved in the maintenance of the normal function of various tissues of the human body including those of the male and female urogenital tract. More recently, PDEs and their main substrates, cyclic GMP and cyclic AMP, have also been assumed to play a crucial role in the control of the human vagina. In order to elucidate the potential significance of phosphodiesterases as marker proteins in female genital organs, it was the aim of the present study to evaluate by means of immunohistochemistry the distribution of cGMP- and cAMP-PDE isoenzymes in specimens of the human vagina. Methods Conventional immunohistochemical techniques (double antibody technique, laser fluorescence microscopy) were applied to sections of the human vaginal wall in order to evaluate the presence of the PDE isoenzymes 1, 2, 3, 4, 5 and 10. Results Immunoreactivities (IR) specific for PDE1 (cAMP/cGMP-PDE, Ca2+/Calmodulin-dependent), PDE2 (cAMP-PDE, cGMP-dependent) and PDE5 (cGMP-PDE) were exclusively registered in the smooth musculature of vaginal arterial vessels, whereas no signals were detected in non-vascular tissue. IR indicating the expression of the cAMP-degrading PDE4 was mainly observed in the vaginal epithelium. Vaginal epithelial cells also presented immunosignals specific for PDE3 (cAMP-PDE, inhibited by cGMP) and PDE10 (dual substrate PDE), nevertheless, these stainings were less abundant than those related to the PDE4. IR for PDE10 was also registered in inflammatory cells located in the subepithelial region of the vaginal wall. Conclusion Our study revealed the presence of IR specific for PDE1, PDE2, PDE4, PDE5 and PDE10 in sections of the human vagina and demonstrated that these enzymes are not evenly distributed in the tissue. Especially, the prominent expression of the cyclic AMP-PDE4A in the vaginal epithelium may give hint to a potential significance of this isoenzyme as a forensic marker protein. The findings give a rationale to investigate further as to whether the immunohistochemical detection of PDE4 may represent a new forensic tool in order to identify human vaginal epithelial cells.
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| 10. |
- Alvinius, Aida, Professor, 1979-, et al.
(author)
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A colossus on clay feet? Mechanisms of inertia in civil-military collaboration within the context of Swedish total defense
- 2024
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In: Defence Studies. - 1470-2436 .- 1743-9698.
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Journal article (peer-reviewed)abstract
- The study examines Sweden’s strategy for total defense, emphasizing inter-sectoral collaboration at the regional level. Specifically, it aims to identify potential challenges in such collaboration, leading to the following overarching research question: What are the principal challenges linked to cross-sector collaboration within Sweden’s total defense strategy at the regional level. The study is based on interviews and observations from various collaborative exercises. Six participants from different organizations specializing in total defense collaboration were interviewed. In addition to interviews, six observations were conducted during different collaborative exercises, each resulting in field notes forming the basis for analysis. Data collection took place between August 2022 and October 2023. The analysis of collected data identifies three overarching themes – inability, unwillingness, and lack of synchronization – depicting the challenges of collaboration in total defense. These themes intertwine and construct a complex situation, described as “a colossus on clay feet,” referring to various mechanisms of inertia in civil-military collaboration. The study concludes that the identified themes pose significant theoretical challenges, suggesting inherent vulnerabilities in the concept that may impede its effectiveness, with the most concerning aspect being the inability to address fundamental problems even amidst increased resources and determination, necessitating a focused research direction to tackle these dilemmas.
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